研究方向：

主要从事金属类化疗药物的化学生物学研究，主要研究方向：基于肿瘤耐药机制的新型四价铂前药的抗肿瘤耐药作用和机制研究。近五年来在Cancer Letters, Biochemical Pharmacology, The Journal of Pharmacology and Experimental Therapeutics, Bioorganic Chemistry, European Journal of Medicinal Chemistry, Metallomics 等本专业领域国际著名刊物上发表第一或通讯作者SCI论文累积影响因子40.094。担任了Cancer Letters, Molecular Pharmacology, European Journal of Medicinal Chemistry, Journal of Inorganic Biochemistry 等国际期刊的学术审稿人。在基于DNA损伤修复的新型四价铂复合物的抗肿瘤耐药作用和机制研究中取得了一定的成果，获得了2018年江苏省教育教学与研究成果奖（研究类）二等奖（排第三）。

发表论文：

第一作者&通讯作者论文：

9. Shixian Hua, Xinyi Wang, Feihong Chen*, Shaohua Gou*. Novel conjugates with dual suppression of glutathione  S- transferases andtryptophan-2,3-dioxygenase activities for improving hepatocellular carcinomatherapy. Bioorganic Chemistry, 2019, 92, 103191.

8. Feihong Chen, Sinan Pei, Xing Wang, Qian Zhu Shaohua Gou*. Emerging JWA-targeted Pt(IV) prodrugs conjugated with CX-4945 to overcome chemo-immuneresistance. Biochemical and Biophysical Research Communications, https://doi.org/10.1016/j.bbrc.2019.10.184

7. Feihong Chen, Shuchen Sun, Nannan Liu, Sinan Pei, Qian Zhu, Xinyi Wang and Shaohua Gou*. Beclin1 affected by DN604 upregulates chemo-sensitivity of cervix SiHa cancer cells via inhibiting CK2-MRN-DSBs repair. Anti-cancer Drugs, 2019, 30， 774-783.

6. Feihong Chen, Xiufeng Jin, Jian Zhao, Shaohua Gou*. DN604: A platinum(II) drugcandidate with classic SAR can induce apoptosis via suppressing CK2-mediated p-cdc25C subcellular localization in cancer cells. Experimental Cell Research, 2018, 364, 68-83.

5. Feihong Chen, Xiaochao Huang, Mian Wu, Shaohua Gou*, Weiwei Hu. A CK2-targeted Pt(IV) prodrug to disrupt DNA damage response. Cancer Letters, 2017, 385, 168-178.

4. Feihong Chen, Xiaodong Qin, Gang Xu, Shaohua Gou*, Xiufeng Jin. Reversal of cisplatin resistance in human gastric cancer cells by a wogonin-conjugated Pt(IV) prodrug via attenuating Casein Kinase 2-mediated Nuclear Factor-kappa B pathways. Biochemical Pharmacology, 2017, 135, 50-68.

3. Feihong Chen, Gang Xu, Xiaodong Qin, Xiufeng Jin and Shaohua Gou*. Hybrid of DNA-targeting chlorambucil with Pt(IV) species to reverse drug resistance. The Journal of Pharmacology and Experimental Therapeutics, 2017, 363(2), 221-239.

2. Feihong Chen, Xinyi Wang, Xiufeng Jin, Jian Zhao, Shaohua Gou*. Oxidative DNA double strand breaks and autophagy in the antitumor effect of sterically hindered platinum(II) complexes in NSCLCs. Oncotarget, 2017, 8(19), 30933-30955.

1. Feihong Chen*, Dan Wang. Inhibition of glioblastoma growth and invasion by 125I brachytherapy in rat glioma model. American Journal of Translational Research, 2017, 9(5), 2243-2254.

共同第一作者论文：

7. Hong Chen#, Feihong Chen#, Sinan Pei, Shaohua Gou*. Pomalidomidehybrids act as proteolysis targeting chimeras: Synthesis, anticancer activityand B-Raf degradation. Bioorganic Chemistry, 2019, 87, 191-199.

6. Shixian Hua#, Feihong Chen#, Gang Xu , Shaohua Gou*. Multifunctional platinum(IV) complexes as immune-stimulatory agents to promote cancer immune-chemotherapy by inhibiting tryptophan-2,3 dioxygenase. European Journal of Medicinal Chemistry, 2019, 169, 29-41.

5. Shixian Hua#, Feihong Chen#, Xinyi Wang, Yuanjiang Wang, Shaohua Gou*. Pt(IV) hybrids containing a TDO inhibitor serve as potential anticancer immune-modulators. Journal of Inorganic Biochemistry, 2019, 195, 130-140.

4. Hong Chen#, Feihong Chen#, Xinyi Wang, Shaohua Gou*. Multifunctional Pt(IV) complexes containing a glutathione S-transferase inhibitor lead to enhancing anticancer activity and preventing metastasis of osteosarcoma cells. Metallomics, 2019, 11(2), 317-326.

3. Hong Chen#, Feihong Chen#, Weiwei Hu, Shaohua Gou*. Effective platinum(IV) prodrugs conjugated with lonidamine as a functional group working on the mitochondria. Journal of Inorganic Biochemistry, 2018, 180, 119-128.

2. Hong Chen#, Feihong Chen#, Nannan Liu, Xinyi Wang, Shaohua Gou*. Chemically induced degradation of CK2 by   proteolysis targeting chimer as T based on aubiquitin–proteasome pathway. Bioorganic Chemistry, 2018, 81, 536- 544.

1. Zhiping Zhou#, Feihong Chen#, Gang Xu, Shaohua Gou*, Study on thecytotoxic activity of platinum(II) complexes of(1R,2R)-N-1-cyclopentyl-1,2-cyclohexanediamine with substituted malonate derivatives. Bioorganic Medicinal Chemistry Letters, 2016, 26(2), 322-327.