作为项目负责人，先后主持包括国家自然科学基金、江苏省自然科学基金等项目：

（1）国家自然科学基金（面上项目):聚ADP核糖酶的高通量检测及其在生物医学中的应用研究， 2018.12.21.12，主持。65万

（2）国家自然科学基金（面上项目）：DNA功能化组装及其在肺癌检测和治疗中的应用研究，2015.1-2018.12，主持。85万

（3）国家自然科学基金（青年基金）：基于纳米探针的DNA损伤检测新方法及其在化学品基因毒性评价中的应用，2013.1-2015.1，主持。25万

（4）江苏省自然科学基金：基于DNA损伤检测的化学品基因毒性评价与筛查新方法，2012.9-2014.12，主持。10万

（5）东南大学-南京医科大学合作项目（重点项目）：基于血清淀粉蛋白A纳米抗体的肺癌早期检测新方法研究。2018-2020，主持。30 万

（6）南京医科大学现代毒理学教育部重点实验室开放基金。主持。5万，2018-2020。

（7）东南大学基本科研业务费（高水平论文及奖励）：23万。主持

（8）南京大学生命分析化学国家重点实验室开放课题，5万，2017-2018。主持

（9）苏州创新培育计划：水产品中氨基糖苷类抗生素残留的检测，主持。

（10）江苏省自然科学基金：纳米纤维在环境污染物高效采样富集器件中的应用技术研究。参与

（11）江苏省自然科学基金：复合二氧化钛纳米管阵列的制备及其氢传感应用研究。参与

（12）国家级自然（社会）科学基金一般项目：食品安全培训与宣传展示。参与

学生培养：

2018年，刘叙获得东南大学优秀硕士论文。

2018年，吴霜霜获得国家奖学金。

2017年，徐晓林获得国家奖学金。

2016年，刘元建、刘叙、吕冰婧获得国家奖学金。

2014年，高春燕获得国家奖学金。

近几年发表论文情况：

2018

1.Peixin Li, Min Wei, Fen Zhang, juanSu, Wei Wei*, Yuanjian Zhang, Songqin Liu.A Novel Fluorescence Switch for MicroRNA Imaging in Living Cells basedon DNAzyme Amplification Strategy.ACS applied materials & interfaces,IF = 8.1。　http://dx.doi.org/10.1021/acsami.8b15330

2.Yong Liu, Jiahui Fan, Haitang Yang,Enshen Xu, Wei Wei*, Yuanjian Zhang, Songqin Liu. Detection of PARP-1 activitybased on hyperbranched-poly (ADP-ribose) polymers responsive current in artificialnanochannels. 2018, Biosensors andBioelectronics 2018, 113, 136–141.IF = 8.3

3.Chunlei Wang, Haitang Yang, Shuangshuang Wu,Yuanjian Liu, Wei Wei*, Yuanjian Zhang, Min Wei*,Songqin Liu. Manifold methods for telomerase activity detectionbased on various unique probes. Trendsin Analytical Chemistry, 2018, 105, 404- 412.IF=7.6

4.Shuangshuang Wu, Min Wei, HaitangYang, Jiahui Fan, Wei Wei*, Yuanjian Zhang, Songqin Liu. Counterions-mediatedgold nanorods-based sensor for label-free detection of poly(ADP-ribose)polymerase-1 activity and its inhibitor. SensorsActuator B, 2018,259, 565-572. IF = 5.4

5.Shuangshuang Wu, Changhui Chen, Haitang Yang, Wei Wei^*,Min Wei^* Yuanjian Zhang, Songqin Liu. Sensors Actuator B, 2018,273, 1047-1053. IF = 5.4

6.Yong Liu, Bingjing Lv, AnranLiu,Geyu Liang, Lihong Yin, Yuepu Pu,Wei Wei*, Songqin Liu.Multicolor sensor fororganophosphorus pesticides determination based on the bi-enzyme catalyticetching of gold nanorods. Sensors ActuatorB, 2018, 265, 675-681.IF = 5.4

7.Ultrasensitive electrochemicaldetection of poly (ADP-ribose) polymerase-1 via polyaniline deposition. Yong Liu, Jiahui Fan, LiShangguan, Yuanjian Liu, Yuanqing Wei, Wei Wei*, Songqin Liu. Talanta, 2018 , 180, 127-132.IF= 4.3

8.YongLiu, Xiaolin Xu, Haitang Yang, Ensheng Xu, Shuangshuang Wu, Wei Wei*, Jin Chen*.Analysis of poly(ADP-ribose) polymerase-1 by enzyme-initiated auto-PARylationcontrolled aggregation of hemin-graphene nanocomposites. Analyst, 2018, 143, 2501 - 2507. 封面论文 IF = 3.8

2017

9.Xu Liu, Min Wei,EnshengXu,Haitang Yang,Wei Wei,^* Yuanjian Zhang,Songqin Liu. A Sensitive, Label-free ElectrochemicalDetection of Telomerase Activity withoutModification or Immobilization. Biosensors andBioelectronics，2017, 91，347-353。IF = 8.3

10.Xiaolin Xu, Yuanjian Liu, Xu Liu,Wei Wei,*Yuanjian Zhang, Songqin Liu. A simple, fast, label-free colorimetricmethod for detection of telomerase activity in urine by using hemin-grapheneconjugates. Biosensors and Bioelectronics，2017, 87, 600-606. IF = 8.3

11.YuanjianLiu, Min Wei, Ying Li, Anran Liu, Wei Wei, ^*Yuanjian Zhang, Songqin Liu. Application of spectral crosstalk correction forimproving multiplexed microRNA detection using a single excitation wavelength. Anal.Chem., 2017, 89, 3430–3436。IF = 6.2

12.Changhui Chen，Min Wei，Yuanjian Liu，Ensheng Xu，Wei Wei，Yuanjian Zhang，Songqin Liu. Visualand fluorometric determination of telomerase activity by using a cationic conjugatedpolymer and fluorescence resonance energy transfer. MicrochimicaActa, 2017, 184, 3453-3460. IF = 5.4

13.Haitang Yang,^#Anran Liu,^# Min Wei, Yuanjian Liu, Bingjing Lv, Wei Wei,* YuanjianZhang, Songqin Liu*. A visual, label-free telomerase activity monitor viaenzymatic etching of gold nanorods. Anal. Chem.2017, 89, 12094-12100.IF = 6.2

2016

14.Yuanjian Liu, Min Wei, XuLiu, Wei Wei, Hongyu Zhao, Yuanjian Zhang andSongqin Liu. Label-free ultrasensitive detection of telomerase activityvia multiple telomeric hemin/G-quadruplexes triggered polyaniline depositionand DNA tetrahedron-structure regulated signal. Chem. Commun., 2016, 52,1796 - 1799. IF=7.4封面论文

15.Xuehong Zhang, Min Wei,Bingjing Lv, Yuanjian Liu, Xu Liu, and Wei Wei*. Sensitive colorimetricdetection of glucose and cholesterol by using Au@Ag core-shell nanoparticles. RSCAdvances, 2016, 6, 35001 - 35007.

16.Linqun Zhang,^#Yuanjian Liua,^# Ying Li, Yuewu Zhao, Wei Wei,* Songqin Liu,*Sensitive electrochemical assaying of DNA methyltransferase activity based onmimic-hybridization chain reaction amplified strategy.Anal. Chim. Acta, 2016, 933,75-81. IF=5.3

17.Yuanjian Liu, Min Wei,Linqun Zhang, Yuanjian Zhang, Wei Wei*, Lihong Yin, Yuepu Pu, Songqin Liu. Chiroplasmonicassemblies of gold nanoparticles for ultrasensitive detection of8-hydroxy-2’-deoxyguanosine in human serum sample. Anal. Chem. 2016, 88,6509-6514.IF=6.2

18.Jingjing Ji, Yuanjian Liu, Wei Wei, Yuanjian Zhang, SongqinLiu. Quantitation of DNA methyltransferase activity via chronocoulometry incombination with rolling chain amplification. Biosensors and Bioelectronics, 2016, 85, 25-31. IF=8.3

19.Bingjing Lv, Min Wei*,Yuanjian Liu, Xu Liu, Wei Wei*, Songqin Liu. Ultrasensitive photometric andvisual determination of organophosphorus pesticides based on the inhibition ofenzyme-triggered formation of core-shell gold-silver nanoparticles. MicrochimicActa. 2016.183, 2941–2948. DOI:10.1007/s00604-016-1939-8。IF=5.2

20.Liu, Xu; Wei, Min; Liu, Yuanjian; Lv, Bingjing; Wei, Wei;Zhang, Yuanjian; Liu, Songqin. Label-free detection of telomerase activity inurine using telomerase-responsive porous anodic alumina nanochannels.Anal. Chem. 2016, 88,8107-8114.IF=6.2

21.JiahuiFan^#, Yuanjian Liu^#, Ensheng Xu, Yuanjian Zhang, WeiWei*, Lihong Yin, Yuepu Pu, Songqin Liu. A label-free ultrasensitive assay of8-hydroxy-2’- deoxyguanosine in human serum and urine samples via polyanilinedeposition and tetrahedral DNA nanostructure. Anal. Chim. Acta. 2016,946, 48-55. IF=5.2

2015

22.Yuanjian Liu, Linqun Zhang, Wei Wei,* Hongyu Zhao, Zhenxian Zhou,Yuanjian Zhang and Songqin Liu. Colorimetric detection of influenza A virususing antibody-functionalized gold nanoparticles, Analyst, 2015, 140, 3989–3995.

23.Linqun Zhang, Min Wei,Chunyan Gao, Wei Wei^*,Yuanjian Zhang, Songqin Liu.Label-freeElectrochemical Detection of Methyltransferase Activity and Inhibitor Screeningbased on Endonuclease HpaII and the Deposition of Polyaniline. Biosens. Bioelectron. 2015,73,188-194. IF=8.3

24.Yuanjian Liu, Min Wei,Linqun Zhang, Wei Wei*, Yuanjian Zhang, Songqin Liu. Evaluation of DNAMethyltransferase Activity and Inhibition via Chiroplasmonic Assemblies of GoldNanoparticles. Chem. Commun. 2015, 51, 76, 14350-14353. IF=7.4

25.Wei Wei, Chunyan Gao, Yanxiang Xiong, Lihong Yin, Yuepu Pu*,Songqin Liu*. A fluorescence method for detection of DNA andDNA methylation based on graphene oxide and endonuclease HpaII. Talanta,131(2015)342–347。

专利申请及授权：

1.卫伟，高春燕，刘松琴。限制性内切酶和核酸外切酶III的无标记荧光检测DNA和DNA甲基化转移酶活性的检测方法。授权号：CN103993083A；申请号：201410220070.8.2015.11.24

2.卫伟，康学军，邓慧华，陆祖宏。蜂王浆中乙酰胆碱的检测方法。授权号：CN101477078 B，授权公告日，2012.04.25,

3.卫伟，熊艳翔，刘松琴。基于氧化石墨烯和限制性内切酶的DNA甲基化检测方法及其试剂盒。授理号：201310472714.8授权号CN103509872 A2016

4.卫伟，倪蔷薇，刘松琴。一种电化学DNA生物传感器及其制备方法与应用。授理号：授权号CN103792274A2016

5.卫伟，康学军，邓慧华，陆祖宏。壮观霉素的毛细管电泳-电致化学发光检测方法。授理号：201010252818

6.卫伟，刘元建，刘松琴。一种金纳米粒子探针比色法检测甲型流感病毒H3N2的方法。授理。 201510152842.3。授权号2016072400171050

7.卫敏，刘叙，卫伟。基于纳米传感和电化学传感定量检测端粒酶活性的方法。授理号：201610319908.8.

8.卫伟，徐晓林，范佳惠，陈昌慧，刘松琴。基于Hemin-石墨烯复合材料的端粒酶活性检测方法。授理号：201610824782.x.

9.卫伟，刘叙，刘松琴。利用亚甲基蓝与G-四链体的结合检测端粒酶活性检测方法。授理号：201610824783.4.

10.卫伟，陈昌慧，刘松琴。基于阳离子水溶性聚合物的荧光可视化定量检测端粒酶活性的检测方法。授理号：201610824309.1.

11.卫伟，范佳慧，张雪红，徐晓林，陈昌慧，刘松琴。基于苯胺沉积的电化学传感定量检测8-OHdG的方法。授理号：201610824784.9.

12.卫伟，刘元建，刘松琴。一种通过荧光法同时检测多种miRNA的方法。授理号：2017100118740

13.卫伟，吴霜霜，刘松琴。一种基于金纳米棒比色法检测多聚腺苷二磷酸核糖聚合酶-1的新方法。授理号：201710669001.9，授理日2017.8.8

14.刘勇，范佳慧，卫伟，基于聚苯胺沉积的定量检测多聚腺苷二磷酸核糖聚合酶-1活性的方法，201710729580.1,2017.08.24

15.刘勇，徐晓林，卫伟，基于hemin-石墨烯复合材料分析检测PARP活性的方法，201710638454.5，2017-07-31