领域：新材料产业 学校：东南大学职称：

有机光功能材料的分子设计、合成策略及应用

有机荧光探针的骨架构筑、分子识别及近红外荧光成像








  工作经历

2000年起任副教授，2007年迄今任教授，2008年迄今任博士生导师。长期从事有机光功能材料的设计、制备、性能及应用研究，在二阶非线性光学材料、三阶非线性光学材料、有机存储材料、多光子上转换荧光材料、有机荧光探针等方面开展工作，主持及参加多项国家自然科学基金项目，其中2012.01-2015.12主持完成国家自然科学基金面上项目“用于生物标记及荧光成像dendrimer分子的多光子上转换荧光发射及荧光共振能量转移”，2007.01-2009.12主持完成国家自然科学基金面上项目“杂环多分支双光子荧光材料的制备、双光子吸收及能量传输”，系统研究有机光功能材料的物理内涵和分子设计策略，构建多光子荧光有机材料库，探索有机共轭π体系的构筑与荧光调控，从分子水平上设计、研究对生物体系中的生理病理学标记物具有特异性识别的有机荧光染料，开展高效多光子荧光染料、宽带多光子吸收材料及荧光探针与分子识别、近红外荧光成像、光动力学治疗等工作，取得系列研究成果，以第一作者或唯一通讯作者发表SCI收录论文90余篇，授权22项国家发明专利。已培养硕士及博士研究生40余名，指导的每届研究生均得到严谨规范的科研训练并取得高质量研究成果，连续5届博士生获得江苏省博士研究生科研创新计划项目，2016级沈宝星博士获得东南大学2018年度博士生国家奖学金。指导的连续8届本科生学位论文被评为东南大学校级优秀毕业论文。主讲研究生课程现代有机合成以及本科生课程有机合成设计。


  钱鹰教授课题组近期发表的部分论文如下:


2019

[1] Xu Chao and Ying Qian*. A selenamorpholine-based redox-responsive fluorescent probe for targeting lysosome and visualizing exogenous/ endogenous hydrogen peroxide in living cells and zebrafish. J. Mater. Chem. B, 2019, 7, 2714
[2] Chengjun Wang and Ying Qian*. A novel BODIPY-based photosensitizer with pH-active singlet oxygen generation for photodynamic therapy in lysosomes. Org. Biomol. Chem., 2019, 17, 8001
[3] Baoxing Shen and Ying Qian*. Red emission cysteine probe with high selectivity based on fluorescent protein chromophores and turn-on fluorescence in cell cultures. Dyes Pigment., 2019, 166, 350
[4] Xin Yang and Ying Qian*. A near-infrared fluorescent probe for the discrimination of cysteine in pure aqueous solutionand imaging of cysteine in hepatocellular carcinoma cells with facilecell-compatible ability. New J. Chem., 2019, 43, 3725
[5] Ronghua Shen and Ying Qian*. A mitochondria-oriented fluorescent probe for ultrafast and ratiometric detection of HSO3- based on naphthalimide-hemicyanine. New J. Chem., 2019, 43, 7606
[6] LuLu Tong and Ying Qian*. A naphthalimide-rhodamine chemodosimeter for hypochlorite based on TBET : High quantum yield and endogeous imaging in living cells. J. Photochem. Photobio. A-Chem., 2019, 368, 62
[7] Lingfeng Wang and Ying Qian*. A novel quinoline-BODIPY fluorescent probe for fast sensing biothiols via hydrogen bonds assisted-deprotonation mechanism and its application in cells and zebrafish imaging. J. Photochem. Photobio. A-Chem., 2019, 372,122
[8] Chunmei Huang and Ying Qian*. A highly sensitive two-photon fluorescent probe for glutathione with near-infrared emission at 719 nm and intracellular glutathione imaging. Spectrochim. Acta A, 2019, 217, 68
[9] Chengjun Wang and Ying Qian*. A TICT-active orthogonal D-A type probe phenothiazine-BODIPY for ratiometric response of hypochlorite and its application in living cells. J. Lumines., 2019, 210, 261


2018
[1] Xiang Xia, Ying Qian*, Baoxing Shen. Synthesis of a novel BODIPY disulfonate near-infrared fluorescence-enhanced probe with high selectivity to glutathione and two-photon fluorescent turn-on through thiol-induced SNAr substitution. J. Mater. Chem. B, 2018, 6, 3023
[2] LuLu Tong and Ying Qian*. A NIR rhodamine fluorescent chemodosimeter specific for Glutathione: Knoevenagel Condensation,detection of intracellular Glutathione and living cell imaging.J. Mater.Chem. B, 2018, 6, 1791
[3] Xin Yang and Ying Qian*.A NIR cell-compatible fluorescent sensor for glutathione based on Michael addition induced cascade spirolactam opening and its application in hepatocellular carcinoma. J. Mater. Chem. B, 2018, 6, 7486
[4] Baoxing Shen and Ying Qian*.
Building rhodamine-BODIPY fluorescent platform using Click reaction: naked-eye visible and multi-channel chemodosimeter for detection of Hg2+and Fe3+.  Sens. Actuators B- Chem., 2018, 260, 666
[5] Chengjun Wang, Xiang Xia, Jirong Luo, Ying Qian*. A novel near-infrared styryl-BODIPY fluorescent probe for discrimination of GSH and itsapplication in living cells. Dyes Pigment., 2018, 152, 85
[6] Chao Xu and Ying Qian*.The α, β-unsaturated pyrazolone-based fluorescent sensor with red emission and its application for real-time monitoring hypochlorite in cancer cells and zebrafish. Dyes Pigment., 2019, 161, 303
[7] Xiang Xia and Ying Qian*. NIR two-photon fluorescent probe for biothiol detection and imaging of living cells in vivo. Analyst, 2018, 143, 5218
[8] Chao Xu, Ying Qian*, Zhengqing Qi, Changgui Lu,Yiping Cui. A conjugated BODIPY- triphenylamine multi-aldoxime: sonogashira coupling,ratiometric chemodosimeter and rapid detection of hypochlorite with two-photon excited fluorescence. New J. Chem., 2018, 42, 6910
[9] Xiuxiu Xu and Ying Qian*. A novel D-π-A BODIPY-stilbene with aggregation-induced red emission and Its interaction with Bovine Serum Albumin. J. Lumines., 2018, 202, 206


2017
[1] Baoxing Shen and Ying Qian*. Click synthesis, Hg2+ sensor and intramolecular fluorescence resonance energy transfer in novel BODIPY dendrons. Sens. Actuators B- Chem., 2017, 239, 226
[2] Shankun Yao and Ying Qian*. A naphthalimide–rhodamine two-photon fluorescent turn-on probe for hypochlorous acid by desulfurization-cyclization and fluorescence resonance energy transfer. Sens. Actuators B- Chem., 2017, 252, 877
[3] Baoxing Shen, Ying Qian*,Zheng-qing Qi, Changgui Lu, Qi Sun, Xiang Xia, Yiping Cui. Near-infrared BODIPY  two-photon ClO- probe based on thiosemicarbazide desulfurization reaction: naked-eye detection and mitochondrial imaging. J. Mater.Chem. B, 2017,5, 5854
[4] Jianfeng Liu and Ying Qian*. A novel naphthalimide-rhodaminedye: intramolecular fluorescence resonance energy transfer and ratiometric chemodosimeter for Hg2+ and Fe3+.  Dyes Pigment., 2017, 136, 782
[5] Xiuxiu Xu and Ying Qian*. A novel (3, 6-di-tert-butylcarbazol-9-yl) Triphenylamine-BODIPY-Tricyanofuran conjugated dye: synthesis and rapid naked-eye detection of  hypochlorite.  New J. Chem., 2017, 41, 9607
[5] Shankun Yao and Ying Qian*. A smart two-photon fluorescent platform based on desulfurization-cyclization: naphthalimide-rhodamine chemodocimeter for Hg2+,NIR emission at 746 nm and through-bond energy transfer.  New J. Chem.,...

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