在Biomaterials,ACS Applied Materials &Interfaces, Bioconjugate Chemistry,International Journal of Pharmaceutics,Nanomedicne(UK) 等杂志上发表高水平研究论文120多篇，获得发明专利授权20多项。成功转让一种可吸收高分子纳米纤维生物材料（三类医疗器械）技术，2004年协助企业获生产许可注册证，是世界上第一个应用于临床的纳米纤维三类医疗器械产品，14年来大规模应用于各大医院外科、骨科、整形外科、胸外科、妇产科等临床手术，受惠患者达到数百万，2014年获四川省人民政府颁发的名牌产品称号，单品种年销售额超亿元，取得巨大的经济效益和社会效益。

 代表性研究论文:

1.MuhammadIsmail, Longbing Ling, Yawei Du, Ruiyu He, Chen Yao, Jianying Shen,  XinsongLi*, Liposomes of dimeric artesunate phospholipid: a combination of dimerizationand self-assembly to combat malaria, Biomaterials, 2018,163:76-87

2.ShuoFang, Yongpeng Hou, Longbing Ling, Chen Yao*, Xinsong Li*, Liposomes assembledfrom di-camptothecin phospholipid with high drug loading for cancer therapy, Colloidsand Surfaces B: Biointerfaces, 2018，available online: 10.1016/j.colsurfb.2018.02.046

3.Lu Lu，Yawei Du，Muhammad Ismail，Longbing Ling，ChenYao，ZhenglinFu，Xinsong Li* ，LiposomesAssembled from Dimeric Retinoic Acid Phospholipid with Improved PharmacokineticProperties, European Journal of Pharmaceutical Sciences, 2018, 112: 186-194

4.Yongpeng Hou, Chen Yao*, Longbing Ling, Yawei Du, Ruiyu He,Muhammad Ismail, Ying Zhang, Zhenglin Fu, Xinsong Li*, Novel Dual VESPhospholipid Self-assembled Liposomes with an Extremely High Drug Loading Efficiency,Colloidsand Surfaces B: Biointerfaces, 2017, 156, 29–37.

5.Longbing Ling, Yawei Du, Ruiyu He, Muhammad Ismail, YongpengHou, Chen Yao, Xinsong Li*, Self-assembled nanoparticles of dualpaclitaxel-phospholipid prodrug with in vitro and in vivo anticanceractivities, International Journal of Pharmaceutics, 2017,  526(1-2),11–22.

6.Yawei Du, Wei Zhang, Ruiyu He, Muhammad Ismail, Longbing Ling,Chen Yao and Xinsong Li* Dual 7-Ethyl-10-hydroxycamptothecin ConjugatedPhospholipid Prodrug Assembled Liposomes with in vitro Anticancer Effects,Bioorganic & Medicinal Chemistry, 2017, 25(12), 3247–3258.

7.Longbing Ling, Chen Yao, Yawei Du, Muhammad Ismail, Ruiyu He,Yongpeng Hou, Ying Zhang, Xinsong Li*, Assembled liposomes of dualpodophyllotoxin phospholipid: preparation, characterization and in vivoanticancer activity, Nanomedicine（UK）,  2017,12(6): 657-672.

8.Ruiyu He, Yawei Du, Longbing Ling, Muhammad Ismail, Yongpeng Hou,Chen Yao and Xinsong Li*, Nanoformulation of dual bexarotene-tailedphospholipid conjugate with high drug loading , European Journal ofPharmaceutical Sciences, 2017, 100: 197–204.

9.Chen Xu, Ruiyu He, Binbin Xie, Chen Yao, Jie Luan, and XinsongLi*,Improved protein resistance of silicone hydrogels by grafting shortpeptides for ophthalmological application, International Journal of Polymeric Materials and PolymericBiomaterials,2017, 66(12), 618-625.

10.Chen Xu, Xiaojiu Liu, BinbinXie, Chen Yao, Wenhan Hu, Yi Li,Xinsong Li. Preparation of PES ultrafiltrationmembranes with natural aminoacids based zwitterionic antifouling surfaces.Applied Surface Science,2016, 385,130-138.

11.Chen Xu,Ruiyu He, Binbin Xie,Muhammad Ismail, Chen Yao, JieLuan, and Xinsong Li*,Silicone hydrogels graftedwith natural aminoacids for ophthalmological application, Journal ofBiomaterials Science, Polymer Edition, 2016, online

12.Wei Zhang, Wenjun Zhu, ShuoFang, YeminZhang, Chen Yao, Muhammad Ismail, Xinsong Li*,Improvementofstability and in vitro anticancer activity ofchlorambucil-tetrapeptideconjugate vesicles, Chinese Journal of Chemistry,2016,on line.

13.Shuo Fang, Yuge Niu,Wei Zhang,Yemin Zhang, Liangli Yu,Yingyi Zhang, and Xinsong Li*,Liposome-likenanocapsules of dual drug-tailed betaine for cancer therapy,International Journal of Pharmaceutics, 2015, 493(1-2), 460–465

14.Xu, Chen; Hu, Xin; Wang, Jie;Zhang, Yemin; Liu, Xiaojiu; Xie,Binbin; Yao, Chen; Li, Yi; Li, Xinsong*, Libraryof Antifouling SurfacesDerived From Natural Amino Acids by Click Reaction, ACSApplied Materials &Interfaces, 2015,7(31):17337-45

15.Xiao-jiu Liu, Ye-min Zhang,Xin-song Li*, Tough biopolymer IPNhydrogel fibers by bienzymatic crosslinkingapproach, Chinese Journal of Polymer Science, 2015,33(12): 1741-1749

16.Zhiping Fan, Yemin Zhang andXinsong Li*,In situ injectablepoly(c-glutamic acid) based biohydrogel formed byenzymatic crosslinking , J.Appl. Polym. Sci. 2015, 2015,132（30）

17.ShuoFang, Yuge Niu, Wenjun Zhu,Yemin Zhang, Liangli Yu and Xinsong Li*, Liposomesassembled from a dualdrug-tailed phospholipid for cancer therapy, Chemistry-an Asian journal, 2015,10(5),1232–1238.

18.Yemin Zhang, Zhiping Fan, ChenXu, Shuo Fang,Xiaojiu Liu, Xinsong Li*,Biopolymer based hydrogelswithinterpenetrating network structure by bienzymaticcrosslinking approach,Europe Polymer Journal, 2015. doi:10.1016/j.eurpolymj.2014.12.038.

19.Zhiping Fan, Yemin Zhang,Jinkai Ji andXinsong Li*,Hybrid polypeptide hydrogels produced via native chemicalligation, RSV Adv., 2015,5, 16470

20.Wenjun Zhu, Shuo Fang, YeminZhang, XinsongLi*, Functional vesicles formed by anticancerdrugassembly,Bioorganic & Medicinal Chemistry Letters25 (2015) 188–191

21.ZhipingFan, Yemin Zhang,Xinsong Li*, BienzymaticallyCrosslinked Gelatin/Hyaluronic acidInterpenetrating Network Hydrogels：PreparationandCharacterization, RSC Adv., 2015, 5, 1929–1936 |

22.XinHu, Lingling Lu, Chen Xu,Xinsong Li*, Mechanically tough biomacromolecular IPNhydrogel fibers byenzymatic and ionic crosslinking, International Journal ofBiologicalMacromolecules, 2015,72: 403–409.

23.Wu, Yang;Ji, Jingkai; Yang,Ran; Zhang, Xiaoqiang; Li, Yuanhui; Pu, Yuepu; Li,Xinsong, Galactosylated2-hydroxypropyl methacrylamide-s-3-guanidinopropylmethacrylamide copolymer assmall hairpin RNA carrier for inhibiting humantelomerase reverse transcriptaseexpression, Journal of Gene Medicine, 2014,16(5-6): 109-121.

24.Yang Wu, Jinkai Ji, XinsongLi*, et al.,Galactosylated Poly(ethylene glycol)Methacrylate-st-3-GuanidinopropylMethacrylamide Copolymers as siRNA Carriersfor Inhibiting Survivin Expression in vitro and in vivo, Journal of DrugTargeting, 2014,22(4): 352-364.

25.Wang, XT ; Dai, Y  ; Zhao,S  ; Tang,JX  ; Li, HJ ; Xing, YT ; Qu, GL; Li, XS  ; Dai, JR ; Zhu,YC ,PAMAM-Lys,a Novel Vaccine Delivery Vector, Enhances theProtective Effects of the SjC23DNA Vaccine against Schistosoma japonicumInfection, PLoS, 2014;9(1):e86578,DOI: 10.1371/journal.pone.0086578.

26.Cai Wen, Lingling Lu,XinsongLi*, An IPN Biohydrogel of Gelatin and Gellan Gum by using CombinationofEnzymatic and Ionic Crosslinking Approaches, PolymerInternational,2014,63:1643-9.

27.Yan Mei, Chen Yao, XinsongLi*,A simple approach to constructing antibacterialand anti-biofoulingnanofibrous membranes, Biofouling, 2014,30(3): 313-322

28.Zongzhe Zhu, XinsongLi,Silicone hydrogels based on a novelamphiphilicpoly(2-methyl-2-oxazoline)-b-poly(dimethyl siloxane) copolymer,Journal ofApplied Polymer Science, online, 2014, 131(3): ?? DOI:10.1002/app.39867

29.Cai Wen, Lingling Lu, XinsongLi*,Mechanically Robust Gelatin-Alginate IPN Hydrogels by a Combination ofEnzymaticand Ionic Crosslinking Approaches, Macromolecular Materials andEngineering,2014, 299(4): 504-13.

30.Yang Wu, Jinkai Ji, XinsongLi*,et al., Guanidinylated 3-gluconamidopropylmethacrylamide-s-3-aminopropylmethacrylamide copolymer as siRNA carriers forinhibiting human telomerasereverse transcriptase expression, Drug delivery,2013;20(7):296-305.

31.Yan Mei, Zhiming Wang,XinsongLi*, Improving filtration performance of electrospun nanofiber mats byabimodal method, Journal of Applied Polymer Science, 2013, 128(2):1089–1094.

32.Xinsong Li*, Zhu Qin, etal.,Improvement of transfection efficiency by galactosylated N-3-guanidinopropylmethacrylamide-co-poly(ethyleneglycol)methacrylatecopolymer,European Polymer Journal, 2013, 49(10): 2884–2894

33.Yan Mei, Chen Yao, KaiFan,Xinsong Li, Surface modification of polyacrylonitrile nanofibrousmembraneswith superior antibacterial and easy-cleaning properties throughhydrophilicflexible spacers, Journal of Membrane Science, Journal ofMembraneScience, 2012, 417–418,20–27.

34.Zhu Qin, Wei Liu, Liang GuoandXinsong Li, Studies on GuanidinatedN-3-AminopropylMethacrylamide-N-2-Hydroxypropyl Methacrylamide Copolymers asGene DeliveryCarrier, Journal of Biomaterials Science-Polymer Edition, 2012,23: 133–152.

35.Zhu Qin, Wei Liu, Liang GuoandXinsong Li, Galactosylated N-2-Hydroxypropyl Methacrylamide-b-N-3-Guanidinopropyl Methacrylamide Block Copolymers as Hepatocyte-TargetingGene Carriers, Bioconjugate Chemistry, 2011, 22 (8), 1503–1512

36.Fuqian Sun, Chen Yao,TangyingSong, Xinsong Li, Fabricationofpoly(vinylidenefluoride-co-hexafluoropropylene) nanofiber yarns byconjugateelectrospinning, The Journal of the Textile Institute, 2011, 102(7):633-638.

37.Jingjing Wang, XinsongLi,Enhancing protein resistance of hydrogels based onpoly(2-hydroxyethylmethacrylate) and poly(2-methacryloyloxyethylphosphorylcholine) withinterpenetrating network structure, Journal of AppliedPolymer Science, 2011,121(6):3347-3352

38.Jinku Xu, Xinsong Li,FuqianSun, In vitro and in vivo Evaluation of Fumarate Ketotifen-LoadedSiliconeHydrogel Contact Lenses for Ocular Drug Delivery, Drug Delivery, 2011;18(2):150–158.

39.Jingjing Wang, XinsongLi,Interpenetrating polymer network hydrogels based on siliconeandpoly(2-methacryloyloxyethyl phosphorylcholine)，Polymersfor Advanced Technologies, 2011,22(12): 2091–2095.

40.Jinku Xu, Xinsong Li,FuqianSun, Cyclodextrin-containing hydrogels for contact lenses as a platformof drugincorporation and release, Acta Biomaterialia, 2010, 6, 486-493.

41.Jinku Xu, Xinsong Li,FuqianSun, Preparation and Evaluation of Contact Lens Vehicle for PuerarinDelivery,Journal of Biomaterials Science-Polymer Edition, 2010,21(3), 271-288.

42.Jinku Xu, Xinsong Li, FuqianSun,Peiting Cao , pPVA Hydrogel Membrane Containing β-cyclodextrin forEnhancedLoading and Sustained Release of Ocular Therapeutics, Journal ofBiomaterialsScience-Polymer Edition, 2010, 21:1023-1038.

43.Jingjing Wang, FuqianSun,Xinsong Li,Preparation and characterization of interpenetrating polymernetworksilicone hydrogels with high oxygen permeability, JOURNAL OF APPLIEDPOLYMERSCIENCE, 2010, 116(5): 2749-2757.

44.Jingjing Wang, FuqianSun,Xinsong Li, Preparation and Antidehydration of Interpenetrating Polymer NetworkHydrogelsBased on 2-Hydroxyethyl Methacrylate and N-Vinyl-2-pyrrolidone,JOURNAL OFAPPLIED POLYMER SCIENCE, 2010, 117, 1851–1858.

45.Chen Yao, Xinsong Li,TangyingSong, Yunhui Li, Yuepu Pu, Biodegradable nanofibrous membrane ofzein/silkfibroin by electrospinning, Polymer International, 2009, 58(4),396-402.

46.Tang-ying Song, ChenYao,Xinsong Li, Preparation and Characterization of Zein andZein/Poly-L-lactide(PLLA) Continuous Nanofiber Yarns, JOURNAL OF APPLIEDPOLYMER SCIENCE,2009,114(4), 2079-2086

47.Yao, Chen;Li, Xinsong; Neoh, K.G.; Shi, Zhilong; Kang, E. T.,Antibacterial activities of surface modifiedelectrospun poly(vinylidenefluoride-co-hexafluoropropylene) (PVDF-HFP) fibrousmembranes, Applied SurfaceScience, 2009, 255(6),3854-3858.

48.Fu GD, Lei JY, Yao C, Li XS,YaoF, Nie SZ, Kang ET, Neoh, KG, Core-sheath nanofibers from combined atomtransferradical polymerization and electrospinning, MACROMOLECULES, 2008,41(18),6854-6858.

49.Yao, C; Li, XS; Neoh,KG,Surface modification and antibacterial activity of electrospunpolyurethanefibrous membranes with quaternary ammonium moieties, JOURNAL OFMEMBRANESCIENCE, 2008, 320(1-2), 259-267.

50.Fu,GD;Yao,F;Li,ZG,Li,XS,Solventresistant antibacterial microfibers of self-quaternizedblockcopolymers from atom transfer radical polymerization andelectrospinning,JOURNAL OF MATERIALS CHEMISTRY, 2008, 18(8), 859-867.

51.Zhiming Li,Feng Shan, JiangongWei, Jun Yang, Xinsong Li andXinling Wang, High ionic conductive PVDF-basedfibrous electrolytes,Journal of Solid State Electrochemistry,2008,12(12),1629-1635

52.Li XS, Yao C, Sun FQ, SongTY,Li YH, Pu YP, Conjugate electrospinning of continuous nanofiber yarn ofpoly(L-lactide)/nanotricalciumphosphate nanocomposite, JOURNAL OF APPLIEDPOLYMER SCIENCE, 2008, 107(6),3756-3764.

53.Chen Yao, Li Xinsong,SongTangying, Electrospinning and Crosslinking of Zein Nanofiber Mats, JournalofApplied Polymer Science, 2007, 103(1), 380–385.

专利、著作版权等