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刘亮伟

领域:生物产业 学校:河南农业大学职称:教授

 从国家粮食安全问题入手,针对发酵工业、饲料业、农产品精深加工业中生物催化的关键酶类——木聚糖酶, 开展微生物酶“生物信息学”研究和“酶分子理性改造”工作,以提高酶分子稳定性、催化活性,达到“提高转化效率、节约粮食、能源”的目的。  科研项目 主持:国家自然科学基金面上项目(31771915):“基于同源/非同源结构置换的木聚糖酶-葡聚糖酶结构元件功能解析” (2018-2021) 主持:国家自然科学基金面上项目(31371831):“基于结构分析的嗜热CBM 拆分-易位-组合融合对木聚糖酶稳定性-活性影响” (2014-2017) 主持:国家自然科学基金面上项目(3097212):“基于pH相关氨基酸定位分析的双功能木聚糖酶耐酸性突变研究” (2010-2012) 主持:河南省重点科技攻关:“木聚糖酶热稳定性的全息酶工程定向改造” 主持:河南省重点科技攻关:“饲料用葡聚糖酶-木聚糖酶双功能酶耐酸性分子改造”...

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教育背景

67.12生于河南省长葛市,91.7兰州大学生物学系学士毕业;
05.7江南大学生物工程学院博士毕业;
05.7河南农业大学生命科学学院,05.12月晋升副教授,
06年招收硕士研究生,12年晋升教授。
“中国酶工程专业委员会委员”,国家自然科学基金评审专家、FEBS Letters、Global Research Journals of Microbiology,生物物理学报、食品与生物技术学报等评审专家。主持国家自然科学基金、河南省重点科技攻关等项目。发表JBC、Plos One、BMC Biotechnology、Process Biochemistry、BBRC等SCI论文。

工作经历

项目课题经历

论文、成果、著作等

2017:
黄亚威,贺添艳,杨昂,上官云杰,徐文选,刘亮伟,双退火温度PCR扩增DNA”,微生物学报,2017,57(8): 1262-1269.
2016
[1] Wenxuan Xu, Yajuan Liu, Yanxin Ye, Meng Liu, Laichuang Han, Andong Song, Liangwei Liu*, C-Terminal carbohydrate-binding module 9_2 fused to the N-terminus of GH11 xylanase from Aspergillus niger, Biotechnology Letters, 38(10), 1739-1745,
[2] 贺添艳 刘亚娟 徐文选 刘猛 刘亮伟,T4 DNA连接酶性质及其平端连接功能,《河南科学》2016,7,1058-1062
[3] 刘猛 刘亚娟 徐文选 贺添艳 刘亮伟,长片断引物反向PCR方法构建重复序列的重组质粒,《河南科学》2016,501-505.
[4] 刘亚娟 刘猛 徐文选 贺添艳 刘亮伟,PEG影响pET20b质粒转化率,《淮阴工学院学报》2016, 3:30-33.
2015
[1] 马闪闪 韩来闯 刘亚娟 刘猛 刘亮伟,CBM2蛋白的高密度自诱导:《中国农学通报》2015,18:140-145.
[2] 韩来闯 马闪闪 刘亚娟 刘猛 刘亮伟,构建重组质粒的二步PCR方法,《河南科学》2015, 8:1321-1325.
2012
[1] Liangwei Liu, Linmin Wang, Zhang Zhang, Suya Wang, and Hongge Chen. Effect of codon message on xylanase thermal activity. J. Biol. Chem, 287(32): 27183-27188. 2012.
[2] Liangwei Liu, Xiaofeng Sun, Pengfei Yan, Linmin Wang, Hongge Chen. Non-structured amino-acid impact on GH11 differs from GH10 xylanase. PLOS ONE, 7(9): e45762. 2012.
[3] Liangwei Liu, Long Chen, Hui Tian, Li Zhao. Using signal peptide prediction with caution, a case study in Aspergillus niger xylanase. Process Biochem, 47: 2527–2530, 2012.
[4] Liangwei Liu, Linmin Wang, Zhang Zhang, Xiaodan Guo, Xiangqian Li, Hongge Chen. Domain-swapping of mesophilic xylanase with hyper-thermophilic glucanase. BMC Biotechnology, 12:28, 2012,
[5] Liangwei Liu, Lingyu Zeng, Suya Wang, Jie Cheng, Xiangqian Li, Andong Song, Kun Wu, Hongge Chen. Activity and thermostability increase of xylanase following transplantation with modules sub-divided from hyper-thermophilic CBM9_1-2. Process Biochem, 47:853-857, 2012.
2011
[1] Liangwei Liu, Guoqiang Zhang, Zhang Zhang, Suya Wang, and Hongge Chen. Terminal amino-acids disturb xylanase thermostability and activity. J Biol Chem, 286:44710-44715, 2011.
[2] Liangwei Liu, Jie Cheng, Hongge Chen, Xiangqian Li, Suya Wang, Andong Song, Mingdao Wang, Bao Wang, Jinwen Shen. Directed evolution of a mesophilic fungal xylanase by fusion of a thermophilic bacterial carbohydrate-binding module. Process Biochem; 46: 395-398, 2011
2010
刘亮伟,程洁,陈红歌,木聚糖酶碳水化合物结合结构域研究进展,生物工程学报,2010, 26:290-296.
2009
[1] Liangwei Liu, Bao Wang, Hongge Chen, Suya Wang, Mingdao Wang, Shimin Zhang, Andong Song, Jinwen Shen, Kun Wu, Xincheng Jia. Rational pH-engineering of the thermostable xylanase based on computational model. Process Biochem; 44:912-915. 2009,
[2]刘亮伟,杨海玉,胡瑜,李相前,F/10木聚糖酶研究进展,食品与生物技术学报,2009,28(6)727-732
2007:
刘亮伟,秦天苍,王宝,刘全军,刘新育,王明道,木聚糖酶的分子进化,食品与生物技术学报,2007,26(6):110-118.
2006-2004
[1] Liangwei Liu,Hongping Dong, Suya Wang, Hongge Chen, Weilan Shao. Computational analysis of dipeptides correlated with the optimal temperature in G/11 xylanase. Process Biochem 2006;41:305–311.
[2] Liangwei Liu, Minglei Wang, Weilan Shao and Weijiang Li. A novel model to determine the dipeptides responsible for optimum temperature in F/10 xylanase. Process Biochem 2005;40:1389–1394.
[3] Liangwei Liu, Hongge Chen, Xincheng jia. The influence of secondary structure content on thermostability of F/10 xylanase. J Biotech, 136:s201, 2008
[4] Liangwei Liu. The Eleventh China-Japan-Korea Joint Symposium on Enzyme Engineering November 5-8, 2010, Chengdu, China,
[5] Liangwei Liu, Xiangqian Li, Xun Li and Weilan Shao. Computational analysis of responsible dipeptides for optimum pH in G/11 xylanase. Biochem Biophys Res Commun 2004; 321: 391– 396.
[6] Liangwei Liu, Jue Zhang, Bin Chen and Weilan Shao. Principle component analysis in F/10 and G/11 xylanase. Biochem Biophys Res Commun 2004;322:277–80.
 
著作
1.主编:《基因工程原理与实验指南》,中国轻工业出版社,2010,
2.副主编:《固态发酵原理》化学工业出版社,2008,
3.副主编:《酶制剂工艺学》化学工业出版社,普通高等教育“十一五”规划教材,2008

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