领域：生物产业 学校：南京大学职称：教授
基于演化生物学、生物信息学和分子生物学，探索表观遗传的调控机制及医学应用；并围绕不同生物之间的相互关系，特别是动植物与微生物之间的关系，研究基因的结构、功能及演化。
1. 不同生物之间相互关系的演化及基因功能研究
1) 植物抗病基因的演化机制及功能
2) 动植物与微生物共生的演化机制及功能
3) 基因组分析及功能演化研究
2. 遗传学和表观遗传学的机制及医学应用
1) 核酸修饰的发生、调控、功能
2) 基于核酸序列及修饰的癌症早筛、早诊及伴随诊断
3) 基于大数据算法的疾病预后、疗效、疗法评估
3. 新型合成生物学／分子生物学工具的开发及应用
1) 新型工具酶的开发和改造
2) 致病微生物及耐药性快速鉴定技术平台的开发和应用
3) 基因编辑／表观修饰编辑工具的开发和应用
4) 新型核酸修饰检测和定位技术的开发和应用
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具体了解该专家信息，请致电：027-87555799 邮箱 haizhi@uipplus.com
代表性论文(* 通讯作者)
1.Wenna Guo，Liucun Zhu,Rui Zhu, Qihan Chen, Qiang Wang*,Jian-Qun Chen*(2019) A four-DNA methylation biomarker is a superior predictor of survival of patients with cutaneous melanoma. eLife2019;8:e44310DOI:10.7554/eLife.44310
2.Zhu-Qing Shao, Jia-Yu Xue, Qiang Wang, Bin Wang, Jian-Qun Chen* (2019)Revisiting the origin of plant NBS-LRR genes. Trends in Plant Science24(1):9-12.
3.Zhuqing Shao, Jiayu Xue, Ping Wu, Yanmei Zhang, Wu Y, Yueyu Hang, Bin Wang*, Jian-Qun Chen* (2016) Large-scale analyses of angiosperm nucleotide-binding site-leucine-rich repeat (NBS-LRR) genes reveal three anciently diverged classes with distinct evolutionary patterns. Plant Physiology170: 2095–2109.
4.Sihai Yang, Long Wang, Ju Huang, Xiaohui Zhang, Yang Yuan, Jian-Qun Chen,Laurence D Hurst, Dacheng Tian (2015) Parent-progeny sequencing indicates higher mutation rates in heterozygotes.Nature523(7561): 463-467.
5.Zhu-Qing Shao, Yan-Mei Zhang, Yue-Yu Hang, Jia-Yu Xue, Guang-Can Zhou, Ping Wu, Xiao-Yi Wu, Xun-Zong Wu, Qiang Wang, Bin Wang*, Jian-Qun Chen*(2014) Long-Term Evolution of Nucleotide-Binding Site-Leucine-Rich Repeat Genes: Understanding Gained from and beyond the Legume Family. Plant Physiology166: 217-234.
6.AmborellaGenome Project (2013) The AmborellaGenome and the evolution of flowering plants. Science342(6165): 1241089.
7.Sihai Yang, Yang Yuan, Long Wang, Jing Li, Wen Wang, Haoxuan Liu, Jian-Qun Chen*, Laurence D. Hurst*, Dacheng Tian*(2012) Great majority of recombination events in Arabidopsis are gene conversion events. Proc Natl Acad Sci U S A109(51): 20992–20997.
8.Jian-Qun Chen, Ying Wu, Hai-Wang Yang, Joy Bergelson, Martin Kreitman, Da-Cheng Tian*(2009) Variation in the ratio of nucleotide substitution and indel rates across genomes in mammals and bacteria. Molecular Biology and Evolution26(7): 1523-1531.
9.Dacheng Tian, Qiang Wang, Pengfei Zhang, Hitoshi Araki, Sihai Yang, Martin Kreitman, Thomas Nagylaki, Richard Hudson, Joy Bergelson, Jian-Qun Chen* (2008) Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes.Nature455: 105-108.
10.Dacheng Tian, Milton Brion Traw, Jian-Qun Chen, Martin Kreitman, Joy Bergelson (2003) Fitness costs of R-gene-mediated resistance in Arabidopsis thaliana. Nature423: 74-77.
