1982－1986年 北京大学生物系生物化学专业，学士
1986－1989年 北京大学生物系生物化学专业，硕士
1989－1995年 美国Rutgers新泽西州立大学微生物学和分子遗传学系，博士

1995－2000年 美国加州大学Santa Barbara分校分子、细胞与发育生物学系，博士后
2000－2003年 美国加州AlleCure/Mannkind免疫生物技术公司研发部，Senior Scientist
2003.7－2015.8 中科院上海生命科学研究院营养科学研究所，研究组长，研究员，博士生导师，“百人计划”择优支持
2015.9－ 武汉大学生命科学学院，教授，博士生导师

2012-2016 国家重大科学研究973计划：“营养失衡导致脂代谢紊乱疾病的病理生理学机制与早期干预研究”，首席科学家
2013-2017 国家自然科学基金重点项目：“细胞内质网应激信号通路在代谢适应性调节中的生理学功能和机制”，负责人
2015-2019 国家自然科学基金重点国际合作项目：“内质网应激与线粒体损伤在慢性肝病发生发展中的作用机制”，负责人

代表性论文:
1) Liu Y, Shao M, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L, Liu Y*. (2015) Role for the Endoplasmic Reticulum Stress Sensor IRE1α in Liver Regenerative Responses. J Hepatol. 62:590-98.

2) Zhang HS, Chen Y, Fan L, Xi QL, Wu GH, Li XX, Yuan TL, He SQ, Yu Y, Shao ML, Liu Y, Bai CG, Ling ZQ, Li M, Liu Y*, Fang J *. (2015) The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis. J Biol Chem. 290:15327-36.

3) Jiang S, Yan C, Fang QC, Shao ML, Zhang YL, Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z, Liu Y*, Jia WP*. (2014) Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts ER stress-induced Hepatic Steatosis. J Biol Chem. 289:29751-65. (Chosen as one of the Best JBC Papers of the Year)

4) Xu T, Yang L, Yan C, Wang X, Huang P, Zhao F, Zhao L, Zhang M, Jia W, Wang X*, Liu Y*. (2014) The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells. Cell Res. 24:1137-40.

5) Shao M, Shan B, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L, Liu Y*. (2014) Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling. Nat Commun. 5:3528.

6) Zhang Q, Liu B, Cheng Y, Meng Q, Xia T, Jiang L, Chen S, Liu Y*, Guo F*. (2014) Leptin signaling is required for leucine deprivation-enhanced energy expenditure. J Biol Chem. 289:1779-87.

7) Zhang C, Li S, Yang L, Huang P, Li W, Wang S, Zhao G, Zhang M, Pang X, Yan Z, Liu Y*, Zhao L*. (2013) Structural modulation of gut microbiota in life-long calorie-restricted mice. Nat Commun. 4:2163.

8) Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L, Liu Y*. (2012) A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors. J Biol Chem. 287(45):37973-85.

9) Yu Y, Sun Y, He S, Yan C, Rui L, Li W, Liu Y*. (2012) Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster. Mol Cell Biol. 32:3610-23.

10) Zhou B, Yang L, Li S, Huang J, Chen H, Hou L, Wang J, Green CD, Yan Z, Huang X, Kaeberlein M, Zhu L, Xiao H, Liu Y* and Han JD*. (2012) Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions. Proc. Natl. Acad. Sci. U.S.A. Plus 109:E1201-9.

11) Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Yi, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W and Liu Y*. (2011) PKA Phosphorylation Couples Hepatic IRE1a to Glucagon Signaling in Glucose Metabolism. Proc. Natl. Acad. Sci. U.S.A . 108:15852-7.

12) Yang L, Zhao L, Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W*, Liu Y*. (2010) Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis. FASEB J. 24:3720-32.

13) Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W, Liu Y*. (2010) Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid compositions of mice. J. Lipid Res. 51:2516-26.

14) You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C* and Liu Y*. (2010) Tyr 985 signaling of leptin receptor as an age/diet-dependent switch in regulation of energy balance. Mol. Cell. Biol. 30:1650-9.
(Highlighted by Editor’s Choice, Science 139, 141, 2010 and Science Signaling 3, ec95, 2010)

15) Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y, Liu Y* and Rui L*. (2010) SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals. Cell Metab. 11:427-37.

16) Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W*, Liu Y*. (2010) A crucial role for RACK1 in regulation of glucose-stimulated IRE1α activation in pancreatic β-cells. Sci. Signal. 3, ra7.
(Highlighted in Perspective, Science Signaling 3, pe7, 2010)

17) Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W and Liu Y* . (2009) Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology 49:1166-75.

18) Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, Yang G, Li W, Li C*, Liu Y* . (2008) Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proc. Natl. Acad. Sci. U.S.A . 105: 18619-24. (Highlighted by Nature China, 2008)

19) Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu F, Franco OH, Wang J, Li H, Liu Y*, Lin X*. (2007) Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J. Clin. Endocr. Metab. 92:4827-34.

20) Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W, Liu Y*. (2006) RNA editing by ADAR2 is metabolically regulated in pancreatic islets and β-cells. J. Biol. Chem. 281:33386-94 .