2003/09-2009/06 武汉大学生命科学学院，病毒学方向，博士 (Wuhan University, PhD)
2005/08-2006/08 芬兰赫尔辛基大学，生物技术研究所，联合培养博士(University of Helsinki, Finland, Joint doctoral student)
1999/09-2003/06 武汉大学生命科学学院，生物技术系，本科 (Wuhan University, Bachelor's Degree)

2011/11-至今， 武汉大学，生命科学学院，病毒学国家重点实验室，副教授 (College of Life Sciences, Wuhan University, Associate Prof.)
2015/9-2015/10，芬兰赫尔辛基大学，微生物系，访问学者 (University of Helsinki, Finland, visiting scholar)
2012/11-2013/01，2011/11-2012/01，2010/01-2010/03，芬兰赫尔辛基大学，生物技术研究所，访问学者 (University of Helsinki, Finland, visiting scholar)
2009/07-2011/10，武汉大学，生命科学学院，师资博士后（讲师） (College of Life Sciences, Wuhan University, lecturer)

1. 国家科技重大专项子任务：基于自体造血干/祖细胞遗传改造的艾滋病基因治疗-新靶标基因鉴定与无毒副作用遗传改造策略，2014-2016，主持；
2. 国家自然科学基金重大项目子课题：埃博拉病原学研究，2015-2017，承担；
3. 国家自然科学基金（面上项目）：靶向冠状病毒关键功能蛋白的抑制剂设计及其抑制效应和机制研究，2017-2020，主持；
4. 国家自然科学基金（面上项目）：冠状病毒RNA加帽酶抑制剂的筛选及抑制机制研究，2013-2016，主持；
5. 国家自然科学基金（青年项目）：冠状病毒非结构蛋白nsp14的RNA外切和甲基化酶功能研究，2011-2013，主持；
6. 中央高校拔尖创新人才资助项目：RNA病毒加帽修饰与免疫逃逸机制研究，2016-2017，主持；
7. 武汉市科技计划项目：冠状病毒RNA 加帽酶抑制剂的高通量筛选及临床前药物的优化，2014-2015，主持。

1.Chen Yu*, Guo Deyin*, 2016. Molecular mechanisms of coronavirus RNA capping and methylation. Virologica Sinica, 31 (1): 3–11.

2.Li Shun, Zhu Mingzhu, Pan Ruangang, Fang Ting, Cao Yuanyuan, Chen Shuliang, Zhao Xiaolu, Lei Chaoqi, Guo Lin, Chen Yu, Li Chunmei, Jokitalo E, Yin Y, Shu Hongbing, Guo D*, 2016. The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nature Immunology, 17(3): 241-9.

3.Zeng Cong, Wu Andong, Wang Yi, Xu Shan, Tang Y, Jin Xu, Wang Shilei, Qin Lei, Sun Ying, Fan C, Snijder EJ, Neuman BW, Chen Yu, Ahola Tero, Guo Deyin*, 2016. Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales.Journal of Virology, JVI.00658-16.

4.Cui Lei, Wang Haiying, Ji Yanxi, Yang Jie, Xu Shan, Huang Xingyu, Wang Zidao, Qin Lei, Tien Po, Zhou Xi, Guo Deyin*, Chen Yu*, 2015. The Nucleocapsid Protein of Coronaviruses Acts as a Viral Suppressor of RNA Silencing in Mammalian Cells. Journal of Virology, 89 (17): 9029-9043.

5.Wang Yi, Sun Ying, Wu Andong, Xu Shan, Pan Ruangang, Zeng Cong, Jin Xu, Ge Xinyi, Shi Zhengli, Ahola Tero, Chen Yu*, Guo Deyin*, 2015. Coronavirus nsp10/nsp16 methyltransferase can be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis. Journal of Virology, 89(16):8416-27.

6.Sun Ying, Wang Zidao, Tao Jiali, Wang Yi, Wu Aangdong, Yang Ziwen, Wang Kaimei, Shi Liqiao, Chen Yu* and Guo Deyin*, 2014. Yeast-based Assays for the High-throughput Screening of Inhibitors of Coronavirus RNA Cap Guanine-N7-methyltransferase. Antiviral Research, 14, 00036-9.

7.Liu Xing, Hao Ruidong, Chen Shuliang, Guo Deyin, Chen Yu*, 2015. Inhibition of Hepatitis B Virus by CRISPR/Cas9 System via Targeting the Conserved Regions of Viral Genome. Journal of General Virology, 96 (8): 2252-61.

8.Wu Andong, Wang Yi, Zeng Cong, Huang Xingyu, Xu Shan, Su Ceyang, Wang Min, Chen Yu*, Deyin Guo*, 2015. Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus. Virus Research, 208:56-65.

9.Chen Yu, Tao Jiali, Sun Ying, Wu Aangdong, Su Ceyang, Gao Guozhen, Cai Hui, Qiu Su, Wu Yingliang, Ahola Tero and Guo Deyin*, 2013. Structure-function analysis of severe acute respiratory syndrome coronavirus RNA cap guanine-N7-methyltransferase. Journal of Virology, 87, 6296-305.

10.Chen Yu, Su Ceyang, Ke Min, Jin Xu, Xu Lirong, Zhang Zhou, Wu Angdong, Sun Ying, Yang Zhouning, Tien Po, Ahola Tero, Liang Yi, Liu Xinqi* and Guo Deyin*, 2011. Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex. PLoS Pathogens, 7, e1002294.

11.Chen Yu, Cai Hui, Pan Ji'an, Xiang Nian, Tien Po, Ahola Tero and Guo Deyin*, 2009. Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase. Proc Natl Acad Sci U S A, 106, 3484-9.

12.Hao Ruidong, He Jing, Liu Xing, Gao Guozhen, Liu Dan, Cui Lei, Yu Guojun, Yu Wenhui, Chen Yu, Guo Deyin*, 2015. Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatocyte Nuclear Factor 6. Journal of Virology, 89, 4345-55.

13.Hou Panpan, Chen Shuliang, Wang Shilei, Yu Xiao, Chen Yu, Jiang Meng, Zhuang Ke, Ho Wenzhe, Hou Wei, Huang Jian, Guo Deyin*, 2015. Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection. Scientific Reports, 5:15577.

14.Yu Xiao, Chen Shuliang, Hou Pangpang, Wang Min, Chen Yu, Guo Deyin*, 2015. VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability. BBRC, 459(2): 270-276.

15.Jin Xu., Chen Yu., Sun Ying., Zeng Cong., Wang Yi., Tao Jiali., Wu Andong., Yu Xiao, Zhang Zhou, Tian Jie. and Guo Deyin*, 2013. Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP. Virus Research, 176, 45-52.

16.Ke Min#, Chen Yu#, Wu Angdong, Sun Ying, Su Ceyang, Wu Hao, Jin Xu, Tao Jiali, Wang Yi, Ma Xiao, Pan Ji'an and Guo Deyin*, 2012. Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2'-O-methyltransferase activity of nsp10/nsp16 complex. Virus Research, 167, 322-8.

17.Zhang Ke, Chen Yu, Pan Ji’an, Ahola Tero and Guo Deyin*, 2009. Lentiviral vector-derived shRNAs confer enhanced suppression of Semliki forest virus replication in BHK-21 cells compared to shRNAs expressed from plasmids. Biotechnol Lett. 31, 501-8.

18.Hussain, Snawa, Pan Ji’an, Chen Yu, Yang Yalin, Xu Jing, Peng Yu, Wu Ying, Li Zhaoyang, Zhu Ying, Tien Po. and Guo Deyin*, 2005. Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus.Journal of Virology, 79, 5288-95.

19.Li Zhaoyang, Xiong Yong, Peng Yu, Pan Ji’an, Chen Yu, Wu Xiaoyun, Hussain Snawa, Tien Po. and Guo Deyin*, 2005. Specific inhibition of HIV-1 replication by short hairpin RNAs targeting human cyclin T1 without inducing apoptosis. FEBS Lett. 579, 3100-6.

1.发明专利：CRISPR/Cas9特异性敲除乙型肝炎病毒的方法以及用于特异性靶向HBV DNA的gRNA，陈宇、郭德银、刘杏、郝瑞栋，201410851870.X，2015年1月4日申请。

2.发明专利：用于艾滋病基因治疗的CRISPR/Cas9重组慢病毒载体及其慢病毒，郭德银、陈述亮、侯盼盼、陈宇，201410770508.X，2014年12月16日申请。

3.发明专利：抗冠状病毒药物高通量筛选方法，郭德银、陈宇，201310542910.8，2013年11月5日申请。

4.发明专利：一种可用于冠状病毒防治的病毒加帽系统多肽抑制剂, 郭德银、陈宇，201210181967.5，2012年6月5日申请。

5.发明专利：一种串联表达小干扰RNA重组慢病毒载体的构建方法，郭德银、柳叶、陈宇，ZL200910062850.3，2012年2月29日授权。

6.发明专利：一种可用于艾滋病基因治疗的多靶点siRNA重组慢病毒载体，郭德银、柳叶、陈宇，ZL200910062851.8，2012年5月9日授权。