在东南大学获得本科和硕士学位（1998-2001），上海交通大学生物化学与分子生物学博士学位（2001-2005）

同年进入系统生物医学研究院工作（2005-2013）。2009年起担任副研究员

作为项目负责人承担国家自然科学青年基金，国家自然科学基金重大研究计划培育项目等项目，参与多项课题研究。



国家自然科学重大研究计划培育项目

非可控性炎症条件下正常胃上皮细胞向肠上皮化生恶性转化的精确动态转录因子调控网络研究

91229108

2013.1-2015.12

负责人


国家自然科学青年基金

建立少量样品的原位转录组学技术进行乳腺癌微环境中巨噬细胞的差异表达谱研究

30900271

2009.1-2011.12

负责人

已发表科研论文28篇。
代表性论文专著
1. Jiangrong Chen*, Chunchao Zhu*, Chaojie Wang*, Chuansheng Hu, Daniel M Czajkowsky, Yan Guo#, Bingya Liu#, Zhifeng Shao#, Evidence for Heightened Genetic Instability in Precancerous Spasmolytic Polypeptide Expressing Gastric Glands. Journal of Medical Genetics. 2019; 0: 1-4

2. Yan Guo, Ayuan Huang, Chuansheng Hu, Yan Zhou, Xiaodan Zhang, Daniel M. Czajkowsky, Jianfang Li, Shidan Cheng, Ruizhe Shen, Jianren Gu, Bingya Liu, Zhifeng Shao, Complex clonal mosaicism within microdissected intestinal metaplastic glands without concurrent gastric cancer, Journal of Medical Genetics. 2016; 53: 643-646

3. Guo Y*, Zhou J*, Huang AY, Li JF, Yan M, Zhu ZG, Zhao XD, Gu JR, Liu BY, Shao ZF, Spatially defined microsatellite analysis reveals extensive genetic mosaicism and clonal complexity in intestinal metaplatic glands, International Journal of Cancer, 2015, 136(12), 2973-2979

4. Yan Guo, Yi Yang, Juan Zhou, Daniel M. Czajkowsky, Bingya Liu, Zhifeng Shao, Microdissection of spatially identified single nuclei in a solid tumor for single cell whole genome sequencing, Biotechniques, 2012, 0(0): 1-3.

5. Runsheng Li*, Yan Guo*, Bang Ming Han, Xiaowei Yan, Angelita G. Utleg, Wei Li, Lan Chun Tu, Jian Wang, Leroy Hood, Shujie Xia, Biaoyang Lin, Proteomics cataloging analysis of human expressed prostatic secretions reveals rich source of biomarker candidates, Proteomics Clin. Appl. 2008, 2, 543–555