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领域:生物产业 学校:武汉大学职称:研究员

病毒入侵机制...

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教育背景

2008.09-2013.06  北京大学/北京生命科学研究所,生物化学与分子生物学 (博士)

2003.09-2008.07  武汉大学医学院,临床医学(学士);武汉大学生命科学学院,生物科学(学士,双学位)

工作经历

2019.11-至今   武汉大学生命科学学院,病毒学国家重点实验室,研究员

2016.08-2019.09  美国南加州大学医学院分子微生物与免疫学系,博士后

2013.07-2016.08  北京生命科学研究所/默沙东研发(中国),联合博士后

项目课题经历

论文、成果、著作等

# co-first author; *corresponding author

1. Yan H, Foo SS, Chen WQ, Shin WJ, Yoo JS, Wu C, Jung JU*. Efficient inhibition of Human Papillomavirus infection by L2 minor capsid-derived lipopeptide. mBio, 2019 Aug 6; DOI: 10.1128/mBio.01834-19

2. Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU*. (2019.04). TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Rep. 27(2):549-560.

3. Qi Y, Gao Z, Xu G, Peng B, Liu C, Yan H, Yao Q, Sun G, Liu Y, Tang D, Song Z, He W, Sun Y, Guo JT, Li W*. DNA Polymerase κ Is a Key Cellular Factor for the Formation of Covalently Closed Circular DNA of Hepatitis B Virus. PLoS Pathog. 2016 Oct 26;12(10):e1005893.

4. He W, Cao Z, Mao F, Ren B, Li Y, Li D, Li H, Peng B, Yan H, Qi Y, Sun Y, Wang F, Sui J, Li W*. Modification of Three Amino Acids in Sodium Taurocholate Cotransporting Polypeptide Renders Mice Susceptible to Infection with Hepatitis D Virus In Vivo. J Virol. 2016 Sep 12;90(19):8866-74.


5. Yan H, Liu Y, Sui J, Li W*. NTCP opens the door for hepatitis B virus infection. Antiviral Res. 2015 Sep;121:24-30.

6. Yan H, Li W*. Sodium taurocholate cotransporting polypeptide acts as a receptor for hepatitis B and D virus. Dig Dis.2015 May; 33(3):388-96.

7. He W, Ren B, Mao F, Jing Z, Li Y, Liu Y, Peng B, Yan H, Qi Y, Sun Y, Guo JT, Sui J, Wang F, Li W*. Hepatitis D Virus Infection of Mice Expressing Human Sodium Taurocholate Co-transporting Polypeptide. PLoS Pathog. 2015 Apr 22;11(4):e1004840.

8. Yan H#, Peng B#, Liu Y, Xu G, He W, Ren B, Jing Z, Sui J, Li W*. Viral Entry of Hepatitis B and D Viruses and Bile Salts Transportation Share Common Molecular Determinants on Sodium Taurocholate Cotransporting Polypeptide.J Virol.2014 Mar;88(6):3273-84.

9. Lin S#, Yan H#, Li L, Yang M, Peng B, Chen S, Li W* and Chen P*. Site-specific Engineering of Chemical Functionalities on the Surface of Live Hepatitis D Virus. Angew. Chem. Int. Ed. 2013 Dec;52(52), 13970-4. (首次报道在活病毒表面指定位点插入非天然氨基酸)

10. Yan H#, Peng B#, He W, Zhong G, Qi Y, Ren B, Gao Z, Jing Z, Song M, Xu G, Sui J, Li W*. Molecular determinants of hepatitis B and d virus entry restriction in mouse sodium taurocholate cotransporting polypeptide. J Virol. 2013 Jul;87(14):7977-91. (F1000 推荐)

11. Zhong G, Yan H, Wang H, He W, Jing Z, Qi Y, Fu L, Gao Z, Huang Y, Xu G, Feng X, Sui J, Li W*. Sodium taurocholate cotransporting polypeptide mediates woolly monkey hepatitis B virus infection of Tupaia hepatocytes. J Virol. 2013 Jun;87(12):7176-84.

12. Yan H#, Zhong G#, Xu G, He W, Jing Z, Gao Z, Huang Y, Qi Y, Peng B, Wang H, Fu L, Song M, Chen P, Gao W, Ren B, Sun Y, Cai T, Feng X, Sui J, Li W*. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife. 2012; 1: e00049. (关于乙肝受体发现的文章,入选 2013 eLife最佳论文,F1000 推荐)

专利、著作版权等

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