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史熊杰

领域:生物产业 学校:武汉大学职称:副教授

1)小肠胆固醇吸收的分子途径;2)细胞内胆固醇动态运输 的分子机制;3)胆固醇代谢调控的信号转导途径和机理;4)胆固醇代谢的药靶系统及新药研发。...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

2005.09–2010.06 中国科学院水生生物研究所 博士
2001.09–2005.06 武汉大学生物科学 本科

工作经历

2014.07–至今   武汉大学生命科学学院 副教授
2014.03–2014.06 中国科学院水生生物研究所 访问学者
2010.08–2013.10 美国匹兹堡大学药学院 博士后

项目课题经历

论文、成果、著作等

1.Xiongjie Shi, Qiuqiong Cheng, Leyuan Xu, Jiong Yan, Mengxi Jiang, Jinhan He, Meishu Xu, Maja Stefanovic-Racic, Ian Sipula, Robert Martin O'Doherty, Shunlin Ren, Wen Xie. Cholesterol Sulfate and Cholesterol Sulfotransferase Inhibit Gluconeogenesis by Targeting HNF4α. Mol. Cell. Biol.2014. vol. 34 no. 3 485-497

2. Jinhan He, Bingfang Hu, Xiongjie Shi, Eric R Weidert, Peipei Lu, Meishu Xu, Min Huang, Eric E Kelley, Wen Xie. Activation of the Aryl Hydrocarbon Receptor Sensitizes Mice to Nonalcoholic Steatohepatitis by Deactivating Mitochondrial Sirtuin Deacetylase Sirt3. Mol. Cell. Biol. 2013, 33 (10) 2047-2055

3. ZhiminOu*, Xiongjie Shi*, Richard K Gilroy, LeventKirisci, Marjorie Romkes, Caitlin Lynch, Hongbing Wang, Meishu Xu, Mengxi Jiang, Songrong Ren, Roberto Gramignoli, Stephen C Strom, Min Huang, Wen Xie. Regulation of the Human Hydroxysteroid Sulfotransferase (SULT2A1) by RORα and RORγ and Its Potential Relevance to Human Liver Diseases. Molecular Endocrinology 2013, 27 (1), 106-115. * Z.O. and X.S. contributed equally to this work.

4. Jie Gao, Jinhan He, Xiongjie Shi, Maja Stefanovic-Racic, Meishu Xu, Robert Martin O’Doherty, Adolfo Garcia-Ocana, Wen Xie. Sex-specific effect of estrogen sulfotransferase on mouse models of type 2 diabetes. Diabetes 2012, 61 (6), 1543-1551.

5. Xiongjie Shi, Leo W. Y. Yeung, Paul K. S. Lam, Rudolf S. S. Wu, and Bingsheng Zhou. Protein Profiles in Zebrafish (Daniorerio) Embryos Exposed to PFOS. Toxicol. Sci. 2009, 110:334-40.

6. Xiongjie Shi, Chunsheng Liu, Guoqiao Wu, and Bingsheng Zhou. Waterborne exposure to PFOS causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae. Chemosphere. 2009, 77:1010-8.

7. Xiongjie Shi, Yongbing Du, Paul K.S. Lam, Rudolf S.S. Wu and Bingsheng Zhou. Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS. Toxicol Appl. pharmacol. 2008, 230: 23-32.

8. Xiongjie Shi, Chunsheng Liu, Yu Ke, Den Jun, Liqin Yu, Bingsheng Zhou. Progress of Toxicological Research on Environmental Endocrine Disruptors and Perspectives. Environ. Chem. (In Chinese), 2009, 21: 340-349.

9. Xiongjie Shi, Bingsheng Zhou. The Role of Nrf2 and MAPK Pathways in PFOS-induced Oxidative Stress in Zebrafish Embryos. Toxicol. Sci. 2010, 115:391-400.

10. Yanhong Wei, Xiongjie Shi, Hongxia Zhang, Jianshe Wang, Bingsheng Zhou, and Jiayin Dai. Combined effects of polyfluorinated and perfluorinated compounds on primary cultured hepatocytes from rare minnow (Gobiocyprisrarus) using toxicogenomic analysis. Aquat. Toxicol. 2009, 95:27-36.
11. Liqin Yu, Jun Deng, Xiongjie Shi, Chunsheng Liu, Ke Yu, and Bingsheng Zhou. Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis of zebrafish larvae. Aquat. Toxicol. 2009, doi:10.1016/j.aquatox.2009.10.022.

12. Jun Deng, Liqin Yu, Chunsheng Liu, Ke Yu, Xiongjie Shi, Leo W.Y. Yeung, Paul K.S. Lam, Rudolf S. S. Wu and Bingsheng Zhou. Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos. Aquat. Toxicol. 2009, 93: 29-36.

13. Chunsheng Liu, Ke Yu, Xiongjie Shi, Jingxian Wang, Paul K.S. Lam, Rudolf S.S. Wu and Bingsheng Zhou. Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromisniloticus). Aquat. Toxicol. 2007, 82: 135-143.

14. M.K. So, Y. Miyake, W.Y. Yeung, Y.M. Ho, S. Taniyasu, P. Rostkowski, N. Yamashita,, Bingsheng Zhou, Xiongjie Shi, J.X. Wang, J.P. Giesy, H. Yu and P.K.S. Lam. Perfluorinated compounds in the Pearl River and Yangtze River of China. Chemosphere. 2007, 68: 2085-2095.

15. Yongbing Du, Xiongjie Shi, Chunsheng Liu, Ke Yu and Bingsheng Zhou. Chronic effects of water-borne PFOS exposure on growth, survival and hepatotoxicity in zebrafish: A partial life-cycle test. Chemosphere. 2009, 74: 723-9.

16. Jingxian Wang, Xiongjie Shi, Yongbin Du and Bingsheng Zhou. Effects of xenoestrogens on the expression of vitellogenin (vtg) and cytochrome P450 aromatase (cyp19a and b) genes in zebrafish (Daniorerio) larvae. J Environ Sci Health ATox Hazard Subst Environ Eng. 2011; 46(9):960-7.

专利、著作版权等

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