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殷雷

领域:生物产业 学校:武汉大学职称:教授

病原识别及药物开发...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

2002 - 2007 博士 中国科学院生物物理研究所生物大分子国家重点实验室
            导师:王大成院士
1998 - 2002 学士 武汉大学生命科学学院基地班专业

工作经历

2014 - 至今 教授 武汉大学生命科学学院病毒学国家重点实验室
2008 - 2013 研究助理 美国霍华德休斯医学研究所(HHMI)
            导师:John Kappler 院士
               Philippa Marrack 院士 英国皇家学会会员

项目课题经历

论文、成果、著作等

1.Wei P, Yang Y, Liu Z, Luo Z, Tu W, Han J, Deng Y, Yin L*. Characterization of Autoantigen Presentation by HLA-C*06:02 in Psoriasis. J Invest Dermatol. 2017 Oct; 137(10):2238-2241 (Highlighted by Commentary in J Invest Dermatol. 2017 Oct; 137:2042-2045) (一区)

2.Wei P, Song G, Shi M, Zhou Y, Liu Y, Lei J, Chen P, Yin L*. Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance. FASEB J. 2017 Oct (cover story, ESI 高被引) (二区)

3.Xiao X, Tang JJ, Peng C, Wang Y, Fu L, Qiu ZP, Xiong Y, Yang LF, Cui HW, He XL,Yin L, Qi W, Wong CL, Zhao Y, Li BL, Qiu WW*, Song BL*. Cholesterol modification of Smoothened is required for hedgehog signaling. Molecular Cell. 2017; 66:1-9 (一区)

4.Hu MM, Yang Q, Xie XQ, Liao CY, Lin H, Liu TT, Yin L, Shu HB*. Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus. Immunity. 2016 Sep 20; 45(3):555-69. (一区)

5.Xia H, Wang P, Wang GC, Yang J, Sun X, Wu W, Qiu Y, Shu T, Zhao X, Yin L, Qin CF, Hu Y, Zhou X*. Human Enterovirus Nonstructural Protein 2CATPase Functions as Both an RNA Helicase and ATP-independent RNA Chaperone. PLOS Pathogens. 2015; 11(7): e1005067. doi: 10.1371/journal.ppat.1005067 (一区)

6.Yang J, Cheng Z, Zhang S, Xiong W, Xia H, Qiu Y, Wang Z, Wu F, Qin CF, Yin L, Hu Y and Zhou X*. A Cypovirus VP5 Displays the RNA Chaperone-like Activity that Destabilizes RNA Helices and Accelerates Stranding Annealing. Nucleic Acids Research. 2014; 42(4): 2538-2554. (一区)

7.Yin L*, Dai S, Clayton G, Gao W, Wang Y, Kappler J, Marrack P*. Recognition of self and altered self by T cells in autoimmunity and allergy. Protein & cell 2013 Jan; 4(1):8-16 (* Corresponding) (二区)

8.Yin L, Crawford F, Marrack P, Kappler J*, Dai S*. T-cell receptor(TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. PNAS(Proceedings of the National Academy of Sciences)2012 Nov 6; 109(45):18517-22 (Recommended by Faculty of 1000) (一区)

9.Yin L, Scott-Browne J, Kappler J, Gapin L, Marrack P*. T cells and their eons-old obsession with MHC. Immunological Reviews. 2012 Nov; 250(1):49-60. (一区)

10.Yin L#, Huseby E#, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S, Kappler J*. A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers. Immunity. 2011 Jul 22; 35(1):23-33(# Contributed equally)
(Highlighted by Commentary in Immunity 2011 Jul 22; 35:1-3, Recommended by Faculty of 1000) (一区)

11.Hu Y#, Gai Y#, Yin L#, Wang X, Feng C, Feng L, Li D, Jiang XN, Wang DC*. Crystal structures of a Populus tomentosa 4-coumarate:CoA ligase shed light on its enzymatic mechanisms. Plant Cell. 2010 Sep; 22(9):3093-104.(# Contributed equally) (一区)

专利、著作版权等

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