1992-1996，武汉大学生物系, 学士
1996-1999，华南农业大学植物细胞分子生物学，硕士
2000-2005，凯西西储大学Case Western Reserve University，药理系，博士
2005－2007，凯西西储大学Case Western Reserve University，医学系，博士后

2008－现在，教授，武汉大学生命科学学院。
2007-2008， 讲师，凯西西储大学Case Western Reserve University，医学系

在研课题：
1. 抑郁症的蛋白质组学和多肽组学研究 (973计划, 课题主持人)
2. SIRT1-p53通路在视网膜缺血再灌注损伤中的关键调控作用（国家自然科学基金, 主持）
3. 母系营养过剩对后代NAFLD传代性影响的研究 （教育部博士点基金，主持）
4. 营养成分失衡与脂肪肝和高脂血症发生的研究 （973计划,课题技术骨干）
5. 组蛋白甲基化在持续营养过剩引发脂肪肝传代性恶化中的关键作用研究（国家自然科学基金, 主持人）
已结题课题
1. 学校自主科研项目
2. 组蛋白翻译后修饰对糖尿病视网膜病变的影响（国家自然科学基金）
3. ADP-核糖在糖尿病并发症中的重要作用（教育部重点项目）
4. 教育部新世纪人才。

代表性论文(*通讯作者)：
1）Li J, Lu D, Dou H, Liu H, Weaver K, Wang W, Li J, Yeh ETH, Williams BO, Zheng L*, Yang T* . Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Nature communications. 2018; 9(1):143.

2) Wan D, Liu C, Sun Y, Wang W, Huang K*, Zheng L*. MacroH2A1.1 cooperates with EZH2 to promote adipogenesis by regulating Wnt signaling. Journal of molecular cell biology. 2017; 9(4):325-337.

3) Liu S, Sun Y, Jiang M, Li Y, Tian Y, Xue W, Ding N, Sun Y, Cheng C, Li J, Miao X, Liu X, Zheng L* and Huang K*. Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase. Hepatology. 2017; 66(2):631-645.

4) Wang W, Wang Q, Wan D, Sun Y, Wang L, Chen H, Liu C, Petersen RB, Li J, Xue W, Zheng L* and Huang K*. Histone HIST1H1C/H1.2 regulates autophagy in the development of diabetic retinopathy. Autophagy. 2017; 13(5):941-954.

5) Sun Y, Xue W, Song Z, Huang K* and Zheng L*. Restoration of Opa1-long isoform inhibits retinal injury-induced neurodegeneration. Journal of molecular medicine. 2016; 94(3):335-346.

6) Huang J, Wan D, Li J, Chen H, Huang K and Zheng L*. Histone acetyltransferase PCAF regulates inflammatory molecules in the development of renal injury. Epigenetics. 2015; 10(1):62-72.

7) Cai R, Xue W, Liu S, Petersen RB, Huang K and Zheng L*. Overexpression of glyceraldehyde 3-phosphate dehydrogenase prevents neurovascular degeneration after retinal injury. FASEB journal. 2015; 29(7):2749-2758.

8) Ding Y#, Li J#, Liu S, Zhang L, Xiao H, Li J, Chen H, Petersen RB, Huang K* and Zheng L*. DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feeding. International journal of obesity. 2014; 38(2):198-204.

9) Li J, Huang J, Li JS, Chen H, Huang K* and Zheng L*. Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets. Journal of hepatology. 2012; 56(4):900-907.

10) Zheng L*, Du Y, Miller C, Gubitosi-Klug RA, Ball S, Berkowitz BA and Kern TS*. Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes. Diabetologia. 2007; 50(9):1987-1996.

11) Zheng L, Howell SJ, Hatala DA, Huang K and Kern TS. Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy. Diabetes. 2007; 56(2):337-345.

12) Zheng L, Szabo C and Kern TS. Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB. Diabetes. 2004; 53(11):2960-2967.