1998 – 2003 中科院上海生命科学研究院生化与细胞所 博士

1994 – 1998 北京大学化学与分子工程学院 本科

2011.12-至今 武汉大学生命科学院 教授

2010.11-2011.11 美国普渡大学生物化学系 研究科学家

2006.11-2010.10 美国普渡大学生物化学系 博士后

2004.2- 2006.10 美国斯坦福大学生物系 博士后

在研课题：
1.国家自然科学基金 “甲基转移酶SETD3在RNA剪接中的作用”（2020-2024）

2.国家自然科学基金 “Plk1蛋白的甲基化修饰负调控自身激酶活性的机制研究” （2018-2022）

近5年代表性研究论文（＊通讯作者）
1) Zheng L#, Shu WJ#, Li YM, Mari M, Yan C, Wang D, Yin ZH, Jiang W, Zhou Y, Okamoto K, Reggiori F, Klionsky DJ, Song Z, Du HN*. (2019) The Paf1 complex transcriptionally regulates the mitochondrial-anchored protein Atg32 leading to activation of mitophagy. Autophagy 19:1-14. doi: 10.1080/15548627.2019.1668228.

2) Li W#, Wang HY#, Zhao X, Duan H, Cheng B, Liu Y, Zhao M. Shu W, Mei Y, Wen Z, Tang M, Guo L, Li G, Chen Q, Liu X, Du HN* (2019) A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair. Sci. Adv. 5(3):eaau7566. doi: 10.1126/sciadv.aau7566.

3) Zhao MJ., Xie J, Shu WJ, Wang HY, Bi J, Jiang W, Du HN* (2019) MiR-15b and miR-22 inhibit SETD3 expression to repress muscle cell differentiation. Cell Death Dis. 10(3):183. doi: 10.1038/s41419-019-1432-5.

4) Cheng X, Hao Y*, Shu W, Zhao M, Zhao C, Wu Y, Peng X, Yao P, Xiao D, Qing G, Pan Z, Yin L, Hu D*, Du HN* (2017) Cell cycle-dependent Degradation of the Methyltransferase SETD3 Suppresses Cell Proliferation and Liver Tumorigenesis. J Biol. Chem. 292(22):9022-9033. doi: 10.1074/jbc.M117.778001.

5) Li F, Zheng LD, Chen X, Zhao XL, Briggs SD, Du HN*. (2017) Gcn5-mediated Rph1 acetylation regulates its autophagic degradation under DNA Damage Stress. Nucleic Acids Res. doi: 10.1093/nar/gkx129.

6) Wang HY, Li Y, Xue T, Cheng N, Du HN* (2016) Construction of a series of pCS2+ backbone-based Gateway vectors for overexpressing various tagged proteins in vertebrates. Acta Biochim Biophys Sin. 48(12): 1128-1134.

7) Zhao Y, Wang X, Wang Q, Deng Y, Li K, Zhang M, Zhang Q, Zhou J, Wang HY, Bai P, Ren Y, Zhang N, Li W, Cheng Y, Xiao W, Du HN, Cheng X, Yin L, Fu X, Lin D, Zhou Q, Zhong B*. (2018) USP2a Supports Metastasis by Tuning TGF-β Signaling. Cell Rep. 22(9):2442-2454. doi: 0.1016/j.celrep.2018.02.007.

8) Xu WC, Liang JZ, Li C, He ZX, Yuan HY, Huang BY, Liu XL, Tang B, Pang DW, Du HN, Yang Y, Chen J, Wang L*, Zhang M*, Liang Y*.(2018) Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111. Cell Death Dis. 9(2):67. doi: 10.1038/s41419-017-0106-4.

9) Lu B, Ren Y, Sun X, Han C, Wang H, Chen Y, Peng Q, Cheng Y, Cheng X, Zhu Q, Li W, Li HL, Du HN, Zhong B*, Huang Z*. (2017) Induction of INKIT by Viral Infection Negatively Regulates Antiviral Responses through Inhibiting Phosphorylation of p65 and IRF3. Cell Host Microbe. 22(1):86-98.e4. doi: 10.1016/j.chom.2017.06.013.

10) Hu JY, Zhang DL, Liu XL, Li XS, Cheng XQ, Chen J, Du HN, Liang Y*. (2017) Pathological concentration of zinc dramatically accelerates abnormal aggregation of full-length human Tau and thereby significantly increases Tau toxicity in neuronal cells. Biochim Biophys Acta Mol Basis Dis. 63(2):414-427. doi: 10.1016/j.bbadis.2016.11.022.