学士. 1983，武汉大学生物系
硕士. 1986, 武汉大学生物系
博士. 1991, 美国内华达大学生物化学系
博士后， 1993－1995，美国弗吉利亚大学
博士后， 1995－1998，美国华盛顿大学

1998-2005.7， Immunex公司/Amgen公司，美国西雅图，历任初级科学家、科学家、高级科学家
2005.8.– 武汉大学生命科学学院教授

代表性论文
Zhou, M. T., Y. Qin, M. Li, C. Chen, X. Chen, H. B. Shu and L. Guo (2015). "Quantitative Proteomics Reveals the Roles of Peroxisome-associated Proteins in Antiviral Innate Immune Responses." Mol Cell Proteomics 14(9): 2535-49.


Li, H. Y., L. K. Zhang, X. J. Zhu, J. Shang, X. Chen, Y. Zhu and L. Guo (2015). "Analysis of EV71 infection progression using triple-SILAC-based proteomics approach." Proteomics 15(21): 3629-43.

Zeng, H. L., X. Rao, L. K. Zhang, X. Zhao, W. P. Zhang, J. Wang, F. Xu and L. Guo (2014). "Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome." J Proteomics 109C: 125-142.

Zhao, X., S. Sidoli, L. Wang, W. Wang, L. Guo, O. N. Jensen and L. Zheng (2014). "Comparative proteomic analysis of histone post-translational modifications upon ischemia/reperfusion-induced retinal injury." J Proteome Res 13(4): 2175-86.

Qin, Y., M. T. Zhou, M. M. Hu, Y. H. Hu, J. Zhang, L. Guo, B. Zhong and H. B. Shu (2014). "RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms." PLoS Pathog 10(9): e1004358.

Yao, Q., B. Q. Liu, H. Li, D. McGarrigle, B. W. Xing, M. T. Zhou, Z. Wang, J. J. Zhang, X. Y. Huang and L. Guo (2014). "C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2." J Biol Chem 289(18): 12666-78.

Tian, H., L. Wang, R. Cai, L. Zheng and L. Guo (2014). "Identification of protein network alterations upon retinal ischemia-reperfusion injury by quantitative proteomics using a Rattus norvegicus model." PLoS One 9(12): e116453.

Yan, J., H. Tian, S. Wang, J. Shao, Y. Zheng, H. Zhang, L. Guo and Y. Ding (2014). "Pollen developmental defects in ZD-CMS rice line explored by cytological, molecular and proteomic approaches." J Proteomics 108C: 110-123.

Zhang, L. K., F. Chai, H. Y. Li, G. Xiao and L. Guo (2013). "Identification of host proteins involved in Japanese encephalitis virus infection by quantitative proteomics analysis." J Proteome Res 12(6): 2666-78.

Hou, D., L. Zhang, F. Deng, W. Fang, R. Wang, X. Liu, L. Guo, S. Rayner, X. Chen, H. Wang and Z. Hu (2013). "Comparative Proteomics Reveal Fundamental Structural and Functional Differences between the Two Progeny Phenotypes of a Baculovirus." J Virol 87: 829-839.

Chen, X., Y. Zhao, G.-M. Li and L. Guo (2013). "Proteomic analysis of mismatch repair-mediated alkylating agent-induced DNA damage response." Cell & Biosciences 3: 37.

Liu, G., H. Tian, Y. Q. Huang, J. Hu, Y. X. Ji, S. Q. Li, Y. Q. Feng, L. Guo and Y. G. Zhu (2012). "Alterations of Mitochondrial Protein Assembly and Jasmonic Acid Biosynthesis Pathway in Honglian (HL)-type Cytoplasmic Male Sterility Rice." J Biol Chem 287(47): 40051-60.

Chen, C., D. Wu, L. Zhang, Y. Zhao and L. Guo (2012). "Comparative phosphoproteomics studies of macrophage response to bacterial virulence effectors." J Proteomics 77: 251-61.

Xu, H., W. Zhang, Y. Gao, Y. Zhao, L. Guo and J. Wang (2012). "Proteomic analysis of embryo development in rice (Oryza sativa)." Planta 235(4): 687-701.

Yao, Q., H. Li, B. Q. Liu, X. Y. Huang and L. Guo (2011). "SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses." J Biol Chem 286(31): 27342-9.

Yu, J. L. and L. Guo (2011). "Quantitative proteomic analysis of Salmonella enterica serovar Typhimurium under PhoP/PhoQ activation conditions." J Proteome Res 10(7): 2992-3002.

Ma, Y., Y. Zhao, R. Zhao, W. Zhang, Y. He, Y. Wu, Z. Cao, L. Guo and W. Li (2010). "Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis." Proteomics 10(13): 2471-85.

Wang, R., F. Deng, D. Hou, Y. Zhao, L. Guo, H. Wang and Z. Hu (2010). "Proteomics of the Autographa californica nucleopolyhedrovirus budded virions." J Virol 84(14): 7233-42.

Zhou, Z., J. B. Fan, H. L. Zhu, F. Shewmaker, X. Yan, X. Chen, J. Chen, G. F. Xiao, L. Guo and Y. Liang (2009). "Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding." J Biol Chem 284(44): 30148-58.

Deng, F., R. Wang, M. Fang, Y. Jiang, X. Xu, H. Wang, X. Chen, B. M. Arif, L. Guo and Z. Hu (2007). "Proteomics analysis of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus identified two new occlusion-derived virus-associated proteins, HA44 and HA100." J Virol 81(17): 9377-85.