1993－1997　南京大学生物科学与技术系，学士
　　　　　　B.S. Biology, Nanjing University, Nanjing, China
1997－2002　中科院上海生命科学研究院生物化学与细胞生物学研究所，博士
　　　　　　Ph.D. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological
　　　　　　Sciences, Chinese Academy of Sciences. 博士

2002－2005 美国德克萨斯大学西南医学中心，博士后
　　　　　　 Post-doctoral research fellow, UT Southwestern Medical Center, Mentors: Drs. Mike
　　　　　　 Brown, Joe Goldstein, Russell DeBose-Boyd

2005－2014 中科院上海生命科学研究院生物化学与细胞生物学研究所，研究组长，研究员，博士生导师，
　　　　　　“百人计划”择优支持，“百人计划”终期评估优秀。分子生物学国家重点实验室副主任（2012
　　　　　　-2014），生化细胞所所长助理（2013-2014）
　　　　　　 Principle Investigator, Institute of Biochemistry and Cell Biology, Shanghai Institutes
　　　　　　 for Biological Sciences, Chinese Academy of Sciences.

2014－至今 武汉大学生命科学学院，教授，院长
　　　　　　 Professor and Dean, College of Life Sciences, Wuhan University, Wuhan, China

PUBLICATIONS (*: Corresponding author):
Representative Publications:

1) Xiao J, Luo J, Hu A, Xiao T, Li M, Kong Z, Jiang L, Zhou Z, Liao Y, Xie C, Chu B, Miao H, Li B,Shi X and Song BL*. Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins. Sci China Life Sci. 2019 May 22. doi:10.1007/s11427-019-9569-9. [Epub ahead of print]


2) Gong XM, Li YF, Luo J, Wang JQ, Wei J, Wang JQ, Xiao T, Xie C, Hong J, Ning G, Shi XJ, Li BL, Qi W* and Song BL*. Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance. Nature Metabolism, 1: 570-583, 2019

3) Zhang YY, Fu ZY, Wei J, Qi W, Baituola G, Luo J, Meng YJ, Guo SY, Yin H, Jiang SY, Li YF, Miao HH, Liu Y, Wang Y, Li BL, Ma YT* and Song BL*. A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption. Science, 360(6393):1087-1092, 2018

4) Wang YJ, Bian Y, Luo J, Lu M, Xiong Y, Guo SY, Yin HY, Lin X, Li Q, Chang CCY, Chang TY, Li BL* and Song BL*. Cholesterol and fatty acids regulate cysteine ubiquitination of ACAT2 through competitive oxidation. Nature Cell Biology, 19(7): 808-819, 2017

5) Xiao X, Tang JJ, Peng C, Wang Y, Fu L, Qiu ZP, Xiong Y, Yang LF, Cui HW, He XL, Yin L, Qi W, Wong CL, Zhao Y, Li BL, Qiu WW* and Song BL*. Cholesterol modification of Smoothened is required for hedgehog signaling. Molecular Cell, 66: 154-162, 2017

6) Li N, Zhou ZS, Shen Y, Xu J, Miao HH, Xiong Y, Xu F, Li BL, Luo J and Song BL*. Inhibition of the SREBP pathway suppresses hepatocellular carcinoma through repressing inflammation. Hepatology, 65(6): 1936-1947, 2017

7) Chu BB, Liao YC, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL and Song BL*. Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts. Cell, 161(2): 291-306, 2015

8) Li PS, Fu ZY, Zhang YY, Xu CQ, Ma YT, Li BL and Song BL*. The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1. Nature Medicine, 20(1): 80-86, 2014

9) Liu TF, Tang JJ, Li PS, Shen Y, Li JG, Miao HH, Li BL* and Song BL*. Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. Cell Metabolism, 16: 213-225, 2012

10) Tang JJ, Li JG, Qi W, Qiu WW, Li PS, Li BL and Song BL*. Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Cell Metabolism, 13: 44-56, 2011

11) Ge L, Wang J, Qi W, Miao HH, Cao J, Qu YX, Li BL and Song BL*. The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metabolism,7: 508-519, 2008

12) Cao J, Wang J, Qi W, Miao HH, DeBose-Boyd RA, Wang J, Li BL* and Song BL*. Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism. Cell Metabolism, 6:115-128, 2007

13) Ge L, Qi W, Wang LJ, Miao HH, Qu YX, Li BL and Song BL*. Flotillins play an essential role in Niemann-Pick C1 Like 1-mediated cholesterol uptake. PNAS, 108(2): 551-6, 2011

14) Song BL, Sever N, and DeBose-Boyd RA. Gp78, a membrane anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. Molecular Cell. 19(6):829-840, 2005

15) Song BL, Javitt NB, and DeBose-Boyd RA. Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. Cell Metabolism, 1: 179-189, 2005

16) Sever N#, Song BL#, Yabe D#, Goldstein JL, Brown MS, and DeBose-Boyd RA. Insig-dependent ubiquitination and degradation of mammalian 3-Hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. J Biol Chem, 278: 52479-52490, 2003


All Publications:

　　　　　　　　　　　　　　　　　　　　 　2019

1. Xiao J, Luo J, Hu A, Xiao T, Li M, Kong Z, Jiang L, Zhou Z, Liao Y, Xie C, Chu B, Miao H, Li B, Shi X, Song BL*. Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins. Sci China Life Sci. 2019 May 22. doi: 10.1007/s11427-019-9569-9. [Epub ahead of print]


2. Gong XM, Li YF, Luo J, Wang JQ, Wei J, Wang JQ, Xiao T, Xie C, Hong J, Ning G, Shi XJ, Li BL, Qi W*, Song BL*. Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance. Nature Metabolism, 1: 570-583, 2019


3. Luo J, Jiang LY, Yang H, Song BL*. Intracellular cholesterol transport by sterol transfer proteins at membrane contact sites. Trends in Biochemical Sciences (Invited review), 44(3): 273-292, 2019


4. Hu A, Song BL*. The interplay of Patched, Smoothened and cholesterol in Hedgehog signaling. Curr Opin Cell Biol. 61: 31-38, 2019


5. Jiang SY, Tang JJ, Xiao X, Qi W, Wu S, Jiang C, Hong J, Xu J*, Song BL*, Luo J*. Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase. PLoS Genet. 15(7): e1008289, 2019


6. Chen L, Ma MY, Sun M, Jiang LY, Zhao XT, Fang XX, Lam SM, Shui GH, Luo J, Shi XJ, Song BL*. Endogenous sterol intermediates of the mevalonate pathway regulate HMG-CoA reductase degradation and SREBP-2 processing. J Lipid Res. 2019 Aug 27. pii: jlr.RA119000201. doi: 10.1194/jlr.RA119000201. [Epub ahead of print]


7. Han Y, Hu Z, Cui A, Liu Z, Ma F, Xue Y, Liu Y, Zhang F, Zhao Z, Yu Y, Gao J, Wei C, Li J, Fang J, Li J, Fan JG, Song BL, Li Y. Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene. Nature Communications, 10(1): 623, 2019


8. Gao M, Huang X, Song BL, Yang H. The biogenesis of lipid droplets: Lipids take center stage. Prog Lipid Res. 75:100989, 2019

　　　　　　　　　　　　　　　　　　　　 　2018

9. Zhang YY, Fu ZY, Wei J, Qi W, Baituola G, Luo J, Meng YJ, Guo SY, Yin H, Jiang SY, Li YF, Miao HH, Liu Y, Wang Y, Li BL, Ma YT*, Song BL*. A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption. Science, 360(6393): 1087-1092, 2018

10. Jiang SY, Li H, Tang JJ, Wang J, Luo J, Liu B, Wang JK, Shi XJ, Cui HW, Tang J, Yang F, Qi W, Qiu WW*, Song BL*. Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol. Nature Communications, 9(1): 5138, 2018

11. Liao YC, Wei J, Wang J, Shi XJ, Luo J, Song BL*. The non-canonical NF-κB pathway promotes NPC2 expression and regulates intracellular cholesterol trafficking. Science China Life Sciences, 61(10): 1222-1232, 2018

12. Jiang LY, Jiang W, Tian N, Xiong YN, Liu J, Wei J, Wu KY, Luo J, Shi XJ*, Song BL*. Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase. Journal of Biological Chemistry, 293(11): 4047-4055, 2018

13. Hu A, Zhao XT, Tu H, Xiao T, Fu T, Wang Y, Liu Y, Shi XJ, Luo J*, Song BL*. PIP4K2A regulates intracellular cholesterol transport through modulating PI(4,5)P2 homeostasis. Journal of Lipid Research, 59(3): 507-514, 2018

14. Guo C, Chi Z, Jiang D, Xu T, Yu W, Wang Z, Chen S, Zhang L, Liu Q, Guo X, Zhang X, Li W, Lu L, Wu Y, Song BL, Wang D*. Cholesterol homeostatic regulator SCAP-SREBP2 integrates NLRP3 inflammasome activation and cholesterol biosynthetic signaling in macrophages. Immunity, 49(5): 842-856, 2018

　　　　　　　　　　　　　　　　　　　　　 2017

15. Wang YJ, Bian Y, Luo J, Lu M, Xiong Y, Guo SY, Yin HY, Lin X, Li Q, Chang CCY, Chang TY, Li BL*, Song BL*. Cholesterol and fatty acids regulate cysteine ubiquitination of ACAT2 through competitive oxidation. Nature Cell Biology, 19(7): 808-819, 2017

16. Xiao X, Tang JJ, Peng C, Wang Y, Fu L, Qiu ZP, Xiong Y, Yang LF, Cui HW, He XL, Yin L, Qi W, Wong CC, Zhao Y, Li BL, Qiu WW*, Song BL*. Cholesterol modification of smoothened is required for hedgehog signaling. Molecular Cell, 66(1): 154-162, 2017

17. Li N, Zhou ZS, Shen Y, Xu J, Miao HH, Xiong Y, Xu F, Li BL, Luo J, Song BL*. Inhibition of the SREBP pathway suppresses hepatocellular carcinoma through repressing inflammation. Hepatology, 65(6): 1936-1947, 2017

18. Wei J, Zhang YY, Luo J, Wang JQ, Zhou YX, Miao HH, Shi XJ, Qu YX, Xu J, Li BL, Song BL*. The GARP complex is involved in intracellular cholesterol transport via targeting NPC2 to lysosomes. Cell Reports, 19(13): 2823-2835, 2017

19. Luo J, Jiang L, Yang H, Song BL*. Routes and mechanisms of post-endosomal cholesterol trafficking: a story that never ends. Traffic (Invited review), 18(4): 209-217, 2017

20. Xie C, Gong XM, Luo J, Li BL, Song BL*. AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse Niemann-Pick type C disease. Journal of Lipid Research, 58(3): 512-518, 2017

21. Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song BL, Han JJ, Rui L, Duan SZ*, Liu Y*. The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nature Immunology, 18(5): 519-529, 2017

22. Liu R, Zou Y, Hong J, Cao M, Cui B, Zhang H, Chen M, Shi J, Ning T, Zhao S, Liu W, Xiong H, Wei C, Qiu Z, Gu W, Zhang Y, Li W, Miao L, Sun Y, Yang M, Wang R, Ma Q, Xu M, Xu Y, Wang T, Chan KK, Zuo X, Chen H, Qi L, Lai S, Duan S, Song BL, Bi Y, Liu S*, Wang W*, Ning G*, Wang J*. Rare loss-of-function variants in NPC1 predispose to human obesity. Diabetes, 66(4): 935-947, 2017

　　　　　　　　　　　　　　　　　　　　　2016

23. Xie C, Zhang YP, Song L, Luo J, Qi W, Hu J, Lu D, Yang Z, Zhang J, Xiao J, Zhou B, Du JL, Jing N, Liu Y, Wang Y, Li BL, Song BL*, Yan Y*. Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome. Cell Research, 26(10): 1099-1111, 2016

24. Su JF, Wei J, Li PS, Miao HH, Ma YC, Qu YX, Xu J, Qin J, Li BL, Song BL, Xu ZP*, Luo J*. Numb directs the subcellular localization of EAAT3 through binding the YxNxxF motif. Journal Cell Science, 129(16): 3104-3114, 2016

25. Yuan Q, Fu Z, Wei J, Li PS, Miao HH, Qu YX, Xu J, Qin J, Li BL, Song BL, Ma Y*. Identification and characterization of NPC1L1 variants in Uygur and Kazakh with extreme low-density lipoprotein cholesterol. Biochemical and Biophysical Research Communications, 479(4): 628-635, 2016

26. Ding L, Li J, Song BL, Xiao X, Zhang B, Qi M, Huang W, Yang L, Wang Z*. Curcumin rescues high fat diet-induced obesity and insulin sensitivity in mice through regulating SREBP pathway. Toxicology and Applied Pharmacology, 304: 99-109, 2016

27. Li J, Ding L, Song BL, Xiao X, Qi M, Yang Q, Yang Q, Tang X, Wang Z, Yang L*. Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway. European Journal of Pharmacology, 770: 99-109, 2016

28. Yang W, Bai Y, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu C, Yan C, Wang L, Chang CC, Chang TY, Zhang T, Zhou P, Song BL, Liu W, Sun SC, Liu X, Li BL*, Xu C*. Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature, 531(7596): 651-655, 2016

29. Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, Chen Y*. PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus. Nature Communications, 6: 8100, 2016

30. Guo D, Lu M, Hu X, Xu J, Hu G, Zhu M, Zhang X, Li Q, Chang CC, Chang T, Song BL, Xiong Y, Li B*. Low-level expression of human ACAT2 gene in monocytic cells is regulated by the C/EBP transcription factors. Acta Biochimica et Biophysica Sinica, 48(11): 980-989, 2016

31. Guo D, Zhang X, Li Q, Qian L, Xu J, Lu M, Hu X, Zhu M, Chang CC, Song BL, Chang T, Xiong Y, Li B*. The ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters. Acta Biochimica et Biophysica Sinica, 48(11): 990-997, 2016

　　　　　　　　　　　　　　　　　　　　　2015

32. Chu BB, Liao YC, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL, Song BL*. Cholesterol transport through lysosome-peroxisome membrane contacts. Cell, 161(2): 291-306, 2015

33. Rogers MA, Liu J, Song BL, Li BL, Chang CC, Chang TY*. Acyl-CoA: cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators. Journal of Steroid Biochemistry and Molecular Biology, 151: 102-107, 2015

34. Xiang Y, Tang JJ, Tao W, Cao X, Song BL, Zhong J*. Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection. Journal of Virology, 89(13): 6805-6816, 2015

35. Zhu M, Zhao X, Chen J, Xu J, Hu G, Guo D, Li Q, Zhang X, Chang CC, Song BL, Xiong Y*, Chang T*, Li B*. ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-α-processing alteration. Acta Biochimica et Biophysica Sinica, 47(12): 951-959, 2015

36. Zhu M, Lei L, Zhu Z, Li Q, Guo D, Xu J, Chen J, Sha H, Zhang X, Yang X, Song BL, Li B*, Yan Y*, Xiong Y*. Excess TNF-α in the blood activates monocytes with the potential to directly form cholesteryl ester-laden cells. Acta Biochimica et Biophysica Sinica, 47(11): 899-907, 2015

　　　　　　　　　　　　　　　　　　　 　2014

37. Li PS, Fu ZY, Zhang YY, Zhang JH, Xu CQ, Ma YT, Li BL, Song BL*. The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1. Nature Medicine, 20(1): 80-86. 2014

38. Wei J, Fu ZY, Li PS, Miao HH, Li BL, Ma YT*, Song BL*. The clathrin adaptor proteins ARH, Dab2, and numb play distinct roles in Niemann-Pick C1-Like 1 versus low density lipoprotein receptor-mediated cholesterol uptake. Journal of Biological Chemistry, 289(48): 33689-33700, 2014

39. Jiang W, Tang JJ, Miao HH, Qu YX, Qin J, Xu J, Yang J*, Li BL, Song BL*. Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis. PLoS One, 9(11): e112632, 2014

40. Ding L, Li J, Song BL, Xiao X, Huang W, Zhang B, Tang X, Qi M, Yang Q, Yang Q, Yang L*, Wang Z*. Andrographolide prevents high-fat diet-induced obesity in C57BL/6 mice by suppressing the sterol regulatory element-binding protein pathway. Journal of Pharmacology and Experimental Therapeutics, 351(2): 474-483, 2014

　　　　　　　　　　　　　　　　　　　　　2013

41. Lu M, Hu XH, Li Q, Xiong Y, Hu GJ, Xu JJ, Zhao XN, Wei XX, Chang CC, Liu YK, Nan FJ, Li J, Chang TY, Song BL*, Li BL*. A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth. Journal of Molecular Cell Biology, 5(6): 404-415, 2013

42. Hu GJ, Chen J, Zhao XN, Xu JJ, Guo DQ, Lu M, Zhu M, Xiong Y, Li Q, Chang CC, Song BL, Chang TY, Li BL*. Production of ACAT1 56-kDa isoform in human cells via trans-splicing involving the ampicillin resistance gene. Cell Research, 23(8): 1007-1024, 2013

43. Liu Y, Xu XH, Chen Q, Wang T, Deng CY, Song BL, Du JL, Luo ZG*. Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development. Nature Communications, 4: 2005, 2013

44. Xiao X*, Song BL. SREBP: a novel therapeutic target. Acta Biochimica et Biophysica Sinica (Invited review), 45(1): 2-10, 2013

45. Xu J, Hu G, Lu M, Xiong Y, Li Q, Chang CC, Song BL, Chang T, Li B*. MiR-9 reduces human acyl-coenzyme A: cholesterol acyltransferase-1 to decrease THP-1 macrophage-derived foam cell formation. Acta Biochimica et Biophysica Sinica, 45(11): 953-962, 2013

　　　　　　　　　　　　　　　　　　　　　2012

46. Liu TF, Tang JJ, Li PS, Shen Y, Li JG, Miao HH, Li BL*, Song BL*. Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. Cell Metabolism, 16(2): 213-225, 2012

47. Xie C, Zhou ZS, Li N, Bian Y, Wang YJ, Wang LJ, Li BL*, Song BL*. Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine. Journal of Lipid Research, 53(10): 2092-2101, 2012

48. Wang LJ, Song BL*. Niemann-Pick C1-Like 1 and cholesterol uptake. Biochimica et Biophysica Acta (Invited review), 1821(7): 964-972, 2012

　　　　　　　　　　　　　　　　　　　　　2011

49. Tang JJ, Li JG, Qi W, Qiu WW, Li PS, Li BL, Song BL*. Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Cell Metabolism, 13(1): 44-56, 2011

50. Ge L, Qi W, Wang LJ, Miao HH, Qu YX, Li BL, Song BL*. Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake. Proceedings of the National Academy of Sciences of the United States of America, 108(2): 551-556, 2011

51. Xie C, Li N, Chen ZJ, Li BL, Song BL*. The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner. Journal of Biological Chemistry, 286(41): 35933-35942, 2011

52. Zhang JH, Ge L, Qi W, Zhang L, Miao HH, Li BL, Yang M, Song BL*. The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. Journal of Biological Chemistry, 286(28): 25088-25097, 2011

53. Wang LJ, Wang J, Li N, Ge L, Li BL, Song BL*. Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers. Journal of Biological Chemistry, 286(9): 7397-7408, 2011

　　　　　　　　　　　　　　　　　　　　　2010

54. Miao HH, Jiang W, Ge L, Li BL, Song BL*. Tetra-glutamic acid residues adjacent to Lys248 in HMG-CoA reductase are critical for the ubiquitination mediated by gp78 and UBE2G2. Acta Biochimica et Biophysica Sinica, 42(5): 303-310, 2010

　　　　　　　　　　　　　　　　　　　　　2009

55. Chu BB, Ge L, Xie C, Zhao Y, Miao HH, Wang J, Li BL, Song BL*. Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. Journal of Biological Chemistry, 284(33): 22481-22490, 2009

56. Wang J, Chu BB, Ge L, Li BL, Yan Y*, Song BL*. Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption. Journal of Lipid Research, 50(8): 1653-1662, 2009

57. Lei L, Xiong Y, Chen J, Yang JB, Wang Y, Yang XY, Chang CC, Song BL, Chang TY, Li BL*. TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation. Journal of Lipid Research, 50(6): 1057-1067, 2009

58. Zhao XN, Chen J, Lei L, Hu GJ, Xiong Y, Xu JJ, Li Q, Yang XY, Chang C, Song BL, Chang TY, Li BL*. The optional long 5'-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay. Acta Biochimica et Biophysica Sinica, 41: 30-41, 2009

　　　　　　　　　　　　　　　　　　　　　2008

59. Ge L, Wang J, Qi W, Miao HH, Cao J, Qu YX, Li BL, Song BL*. The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metabolism, 7(6): 508-519, 2008

60. Qi W, Song BL*. Dissecting the NPC1L1-mediated cholesterol absorption. Future Lipidology (Invited review), 3: 481-484, 2008

61. Chen J, Zhao XN, Yang L, Hu GJ, Lu M, Xiong Y, Yang XY, Chang CC, Song BL, Chang TY, Li BL*. RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform. Cell Research, 18(9): 921-936, 2008

　　　　　　　　　　　　　　　　　　　　　2007

62. Cao J, Wang J, Qi W, Miao HH, Wang J, Ge L, DeBose-Boyd RA, Tang JJ, Li BL*, Song BL*. Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase. Cell Metabolism, 6(2): 115-128, 2007

　　　　　　　　　　　　　　　　　　　　　2002-2005

63. Song BL, Sever N, DeBose-Boyd RA*. Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. Molecular Cell, 19(6): 829-840, 2005

64. Song BL, Javitt NB, DeBose-Boyd RA*. Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. Cell Metabolism, 1(3): 179-189, 2005

65. Song BL*, DeBose-Boyd RA*. Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols. Journal of Biological Chemistry, 281(35): 25054-25061, 2006

66. Song BL, DeBose-Boyd RA*. Ubiquitination of 3-hydroxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase. Journal of Biological Chemistry, 279(27): 28798-28806, 2004

67. Sever N#, Song BL#, Yabe D#, Goldstein JL, Brown MS, DeBose-Boyd RA*. Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. Journal of Biological Chemistry, 278(52): 52479-52490, 2003

68. Lee JN, Song BL, DeBose-Boyd RA, Ye J*. Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78. Journal of Biological Chemistry, 281(51): 39308-15, 2006

69. Sever N, Lee PC, Song BL, Rawson RB, Debose-Boyd RA*. Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Journal of Biological Chemistry, 279(41): 43136-43147, 2004