1989-1996 安徽农业大学 本科、硕士
1996-1999 中国科学院上海生物化学研究所 博士

1999-2000 中国科学院上海生物化学研究所 研究助理
2000-2008 美国爱因斯坦医学院 博士后、研究助理
2008-2018 中国科学院上海植物生理生态研究所 研究员（百人计划，杰青）
2018- 武汉大学生命科学学院 教授

　2015-2017 中国科学院重点部署项目“剪接体复合物的高效表达系统与作用机制研究”，首席
　2015-2017 国家自然科学基金重大研究计划“长非编码RNA表达的剪接调控机制”，主持

1) Qiu C, Zhang Y, Fan YJ, Pang TL, Su Y, Zhan S*, Xu YZ* (2018). HITS-CLIP reveals sex-differential RNA binding and alterative splicing regulation of SRm160 in Drosophila. Journal of Molecular Cell Biology, in press.

2) Tang Q, Rodriguez-Santiago S, Wang J, Pu J, Yuste A, Gupta V, Moldón A, Xu YZ*, Query CC* (2016). SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing. Genes & Development 30(24): 2710-2723.

3) Gao JL, Fan YJ, Wang XY, Zhang Y, Pu J, Li L, Shao W, Zhan S, Hao J, Xu YZ* (2015). A conserved intronic U1 snRNP-binding sequence promotes trans-splicing in Drosophila. Genes & Development 29(7): 760-771.

4) Qiu C, Liu WY*, Xu YZ* (2015). Fluorescence labeling of short RNA by oxidation at the 3'-end. Methods in Molecular Biology 1297: 113-120.

5) Wang XY, Zheng ZZ, Song HS, Xu YZ* (2014). Conserved RNA cis-elements regulate alternative splicing of Lepidopteran doublesex. Insect Biochemistry and Molecular Biology 44(1), 1-11.

6) Zhang ZM, Yang F, Zhang J, Tang Q, Li J, Gu J, Zhou J*, Xu YZ* (2013). Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly. Cell Reports 5, 1269-1278.

7) Yang F, Wang XY, Zhang ZM, Pu J, Fan YJ, Zhou J, Query CC, Xu YZ* (2013). Splicing proofreading at 5' splice sites by ATPase Prp28p. Nucleic Acids Research 41(8), 4660-4670.

8) Shao W, Zhao QY, Wang XY, Xu XY, Li MW, Li X* and Xu YZ* (2012). Alternative splicing and trans-splicing events revealed by analysis of the Bombyx mori transcriptome. RNA 18(7), 1395-1407.

9) Shao W, Kim HS, Cao Y, Xu YZ*, Query CC* (2012). A U1–U2 snRNP interaction network during intron definition. Molecular and Cellular Biology 32(2), 470-478.

10) Xu YZ and Query CC (2007). Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly. Molecular Cell 28(5), 838-849.

11) Xu YZ, Newnham CM, Kameoka S, Huang T, Konarska MM and Query CC (2004). Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA. The EMBO Journal 23(2), 376-385.