教育背景
2002年毕业于四川大学华西药学院药学专业,获药学学士学位,2005年毕业于四川大学华西药学院,获药物化学硕士学位。2009年在四川大学华西药学院获天然药物化学博士学位
工作经历
同年进入四川农业大学农学院中草药栽培与鉴定教研室,从事科研及教学工作,2013年8月至2014年8月在美国宾夕法尼亚大学化学系做访问学者一年,2016年9月进入西南交通大学生命科学与工程学院,
项目课题经历
主持国家自然科学基金面上项目2项,自然基金青年项目、教育部博士点基金和四川省科技支撑计划各1项。1. 基于构型翻转的抗肿瘤续随子二萜结构修饰、构效关系及作用机制研究
国家自然科学基金面上项目 2019.1—2022.12
2. 结构简化的紫杉醇模拟物的设计、合成及活性研究
国家自然科学基金面上项目 2016.1—2019.12
3. 基于天然产物的小分子微管稳定剂的设计、合成及抗癌活性研究
四川省科技厅支撑计划 2015.1—2017.12
4. 简化紫杉醇的合成及抗癌活性研究
留学归国人员启动基金优先资助 2016.1—2017.12
5. 新一代紫杉醇类似物的设计、合成及活性研究
国家自然科学基金青年基金 2011.1—2013.12
6. 新型紫杉醇衍生物的合成及抗癌活性评价
教育部博士点新教师基金 2011.1—2013.12
7. 草乌甲素结构修饰及镇痛活性研究
四川省教育厅青年基金 2010.1—2012.12
8. 四川农业大学“高端人才”人才基金资助
四川农业大学2010—2016
论文、成果、著作等
在天然药物化学领域的权威期刊《J. Am. Chem. Soc.》《Chem. Sci.》,《Chem. Comm.》, 《Org. Lett.》,《Org. Biomol. Chem.》,《J. Nat. Prod.》,《Tetrahedron Lett.》, 《Fitoterapia》,《Phytochemistry》等以发表论文50多篇,均被SCI收录,学术论文:
1. Zhong-Sheng Wang, Wei Chen, Hai-Yue Jiang, Feng Gao∗, Xian Li Zhou∗, Semi-synthesis and structural elucidation of brevicanines A–D, four new C19-diterpenoid alkaloids with rotameric phenomenon from Aconitum brevicalcaratum, Fitoterapia, 2019, 134, 404-410.
2. Jia-Xi Wang, Ling-Li Zheng, Feng Gao∗, Xian Li Zhou∗, Lewis acid-mediated skeleton transformation of Euphorbia diterpenes: From lathyrane to euphoractane and myrsinane, Fitoterapia, 2019, 133, 212-218.
3. Yun-Xin Yao, Dong-Mei Fang, Feng Gao*, Xiao-Xia Liang, Room-temperature palladium-catalyzed direct 2-alkenylation of azole derivatives with alkenyl bromides, Tetrahedron Lett., 2019, 60, 68-71.
4. Xiaoyun Lei, Shuai Huang, Hu Xiao, Feng Gao*, and Xianli Zhou, A New Taxane Diterpenoid and a New Neolignan from Taxus baccata, Nat. Prod. Commun., 2018, 13, 1425-1428
5. Yun-Xin Yao, Nan-Nan Jia, Ya-Nan Cao, Xing-Xiu Chen, Feng Gao*, Xiao-Xia Liang, Copper-Catalyzed Synthesis, Bio-Evaluation, and in Silico Studies of 2-Aryl-N-Alkylbenzimidazoles as Neuroprotective Agents, Catalysts, 2018, 8, 433.
6. Lin Chen, Shuai Huang, Chun Ying Li, Feng Gao∗, Xian Li Zhou∗, Pyrrolizidine alkaloids from Liparis nervosa with antitumor activity by modulation of autophagy and apoptosis, Phytochemistry, 2018, 153, 147–155.
7. Jia-Xi Wang, Qian Wang, Yong-Qi Zhen, Shuang-Mei Zhao, Feng Gao,* Xian-Li Zhou,* Cytotoxic Lathyrane-type Diterpenes from Seeds of Euphorbia Lathyris, Chem. Pharm. Bull., 2018, 66, 674-677.
8. Ya-Nan Cao, Ling-Li Zheng, Dan Wang, Xiao-Xia Liang*, Feng Gao* and Xian-Li Zhou, Recent advances in Microtubule-stabilizing Agents, Eur. J. Med. Chem., 2018, 143, 806-828.
9. Ji-Fa Zhang, Lin Chen, Shuai Huang, Lian-Hai Shan, Feng Gao,* and Xian-Li Zhou*, Diterpenoid Alkaloids from Two Aconitum Species with Antifeedant Activity against Spodoptera exigua, J. Nat. Prod., 2017, 80, 3136–3142.
10. Yan-Nan Cao, Xin-Chuan Tian, Xing-Xiu Chen, Yun-Xin Yao, Feng Gao*, Xian-Li Zhou*, Rapid Ligand-Free Base-Accelerated Copper-Catalyzed Homo-coupling Reaction of Arylboronic Acids, Synlett, 2017, 28, 601-606.
11. Nan-Nan Jia, Xin-Chuan Tian, Xiao-Xia Qu, Xing-Xiu Chen, Ya-Nan Cao, Yun-Xin Yao, Feng Gao*, Xian-Li Zhou, Copper-catalyzed Direct 2-Arylation of Benzoxazoles and Benzoimidazoles with Aryl Bromides and Cytotoxicity of Products, Scientific Reports, 2017, 7, 43758.
12. Tianyi Liu, Annemarie L. Exarhos, Ethan C. Alguire, Feng Gao, Elmira Salami-Ranjbaran, Kevin Cheng, Tiezheng Jia, Joseph E. Subotnik, Patrick J. Walsh, James M. Kikkawa, and Zahra Fakhraai, Phys. Rev. Lett., 2017, 119, 095502.
13. Jiadi Zhang, Sheng-Chun Sha, Ana Bellomo, Nisalak, Trongsiriwat, Feng Gao, Neil Tomson*, Patrick J. Walsh*, Positional Selectivity in C–H Functionalizations of 2-Benzyl Furans with Bimetallic Catalysts, J. Am. Chem. Soc., 2016, 138, 4260-4266
14. Feng Gao, Byeong-Seon Kim and Patrick J. Walsh*, Chemoselective Palladium-Catalyzed Deprotonative Arylation/[1,2]-Wittig Rearrangement of Pyridylmethyl Ethers, Chem. Sci., 2016, 7, 976-983. (IF = 9.21) (Highlighted by Synfacts (2016, 12, 0243)) (Reported by Synform)
15. Guan Wen, Xiao-Xia Qu, Dan Wang, Xing-Xiu Chen, Xing Chuan Tian, Feng Gao*, Xian-Li Zhou*, Recent advances in design, synthesis and bioactivity of paclitaxel-mimics, Fitoterapia, 2016, 110, 26-37.
16. Ling-Li Zheng, Guan Wen, Min-Yong Yuan, Feng Gao*, Ultrasound-Assisted Extraction of Total Flavonoids from Corn Silk and Their Antioxidant Activity, J. Chem., 2016, Article ID 8768130.
17. Dan Wang, Hong-Guan Chen, Xin-Chuan Tian, Xiao-Xia Liang, Feng-Zhen Chen and Feng Gao*, Room-Temperature Palladium-Catalysed Suzuki-Miyaura Coupling of Arylboric Acid with Aryl Chlorides, RSC adv., 2015, 5, 107119-107122.
18. Byeong-Seon Kim, Jacqueline, Jiménez, Feng, Gao, and Patrick J. Walsh*, Palladium-Catalyzed Benzylic C–H Arylation of Azaarylmethylamines, Org. Lett., 2015, 17, 5788–5791.
19. Tianyi Liu, Kevin Cheng, Elmira Salami-Ranjbaran, Feng Gao, Ethan C. Glor, Mu Li, Patrick J. Walsh* and Zahra Fakhraai*, Soft Matter, 2015, 11, 7558-7566.
20. Tianyi Liu, Kevin Cheng, Elmira Salami-Ranjbaran, Feng Gao, Chen Li, Xiao Tong, Yi-Chih Lin, Yue Zhang, William Zhang, Lindsey Klinge, Patrick J. Walsh*, and Zahra Fakhraai*, The effect of chemical structure on the stability of physical vapor deposited glasses of 1,3,5-triarylbenzene, J. Chem. Phys., 2015, 143, 084506.
21. Dan Wang, Bi‑Bo Zhang, Xiao‑Xia Qu, Feng Gao*, Min‑Yong Yuan, Microwave‑assisted extraction of polysaccharides from Yupingfeng powder and their antioxidant activity, Phcog. Mag., 2015, 11, 546-554.
22. Feng Gao*, Xin-ChuanTian, Xiao-Xia Qu, Dan Wang, Dong Pu, Highly efficient environment-friendly “one-pot” Synthesis of 2-substituted-4-formylimidazoles from 4-acylaminoisoxazoles, Synthesis, 2015, 47, 65-70.
23. Feng Gao, Byeong-Seon Kim and Patrick J. Walsh*, Room-temperature palladium-catalyzed direct 2-arylation of benzoxazoles with aryl and heteroaryl bromides, Chem. Comm., 2014, 50, 10661-10664.
24. Xin-ChuanTian, Xing Huang, Dan Wang, and Feng Gao*, Eco-efficient one-pot synthesis of quinazoline-2,4(1H,3H)-diones at room temperature in water, Chem. Pharm. Bull., 2014, 62, 824-829.
25. Xing-Xiu Chen, Feng Gao*, Qi Wang, Xing Huang, Dan Wang, Design, synthesis and biological evaluation of paclitaxel-mimicspossessing only the oxetane D-ring and side chain structures, Fitoterapia, 2014, 92, 111-115. (Featured by MDlinx.com)
26. Ling Li Zheng, Dan Wang, Yuan Yuan Li, Hong Yan Peng, Ming Yong Yuan, Feng Gao*, Ultrasound assisted extraction of total flavonoids from Aconitum gymnandrum, Pharmacog., Mag., 2014, 10, S141-146.
27. Dan Wang, and Feng Gao*, Quinazoline derivatives: synthesis and bioactivities, Chem. Cent. J., 2013, 7, 95. (Highly Accessed)
28. Feng Gao*, Dan Wang, and Xing Huang, Synthesis, isolation, stereostructure and cytotoxicity of paclitaxel analogs from cephalomannine, Fitoterapia, 2013, 90, 79-84. (Featured by MDlinx.com)
29. Feng Gao*, Min Yu, Qiao-Hong Chen, and Feng-Peng Wang*, A Selective IntramolecularTransacylation of Taxoids Accompanying with the Oxetane Ring Opening, Chem. Pharm. Bull., 2012, 3, 415-418.
30. Feng Gao, Zhan-Kun Yang, Qiao-Hong Chen, Xiao-Guang Chen, and Feng-Peng Wang*, A novel D-ring modified taxoid: synthesis and biological evaluation of a gama-lactone analogue of docetaxel, Org. Biomol. Chem., 2012, 10, 361-366.
31. Feng Gao*, Yuan-Yuan Li, Dan Wang, Xing Huang and Qian Liu, Diterpenoid Alkaloids from the Chinese Traditional HerbaFuzi and Their Cytotoxic Activity, Molecules, 2012, 17, 5187-5194.
32. Feng Gao*, Shou-An Zhu, Wei Wua, Xue-Gui Wang, Lei Song, C19-Diterpenoid alkaloids from the roots of Aconitum hemsleyanum var. hanyuanum and their chemotaxonomic significance, Biochem. Syst. Ecol., 2010, 38, 1052-1055.
33. Feng Gao, Xiao-Yu Liu, and Feng-Peng Wang*, Three New C19-Diterpenoid Alkaloids from Aconitum hemsleyanumvar.circinatum, Helv. Chim. Acta, 2010, 93, 785-790. (IF = 1.32)
34. Feng Gao, Qiao-Hong Chen, and Feng-Peng Wang*, Platinum-Triethylamine Catalyzed Hydrogenation of Aldehydes and Cyclohexanones, Tetrahedron Lett., 2009, 50, 5270-5273.
35. Feng Gao, Qiao-Hong Chen, and Feng-Peng Wang*, C19-Diterpenoid Alkaloids from Aconitum hemsleyanum var. circinatum, J. Nat. Prod., 2007, 70, 876-879.
36. Feng Gao, Dong-Lin Chen, and Feng-Peng Wang*, New Aconitine-Type C19-Diterpenoid Alkaloids from Aconitum hemsleyanium var. circinacum, Arch. Pharm. Res., 2007, 30, 1497-1500.
37. Feng Gao, Dong-Lin Chen, and Feng-Peng Wang*, Two new C19-diterpenoid alkaloids from Aconitum hemsleyanium var. circinacum, Chem. Pharm. Bull., 2006, 54, 117-118.
38. Pei-Geng Xiao*, Feng-Peng Wang, Feng Gao, Lu-Ping Yan, Dong-Lin Chen, Yong Liu, A pharmacophylogenetic study of Aconitum L. (Ranunculaceae) from China, Acta Phytotaxonomic Sinica, 2006, 44, 1-46. (第五届中国科协期刊优秀学术论文奖)
39. Feng Gao, and Feng-Peng Wang*, Structural revision of hemsleyadine and new alkaloids hemsleyanines A, B from Aconitum hemsleyanium var. circinacum, Heterocycles, 2005, 66, 365-370.
专利、著作版权等
授权专利1项。1.高峰,任丽红 汉源乌头中一种新型C19-二萜生物碱及其在制备抗肿瘤药物中的应用 申请号:20111026625.8
2.高峰, 陈星秀,王丹 类紫杉醇化合物及其制备和在抗癌药物中的应用
授权号:CN201310118861.5
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