首页 > 专家库
黄新河

领域:生物产业 学校:西南交通大学职称:副教授

(i) 衰老及衰老相关疾病发生发展的分子机制【机理研究组】; (ii) 抗衰老及衰老相关疾病药物学【药理研究组】; (iii) 新型抗衰品(包括药品、妆品和食品)研发【应用研究组】。...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

1998.9~2002.6, 四川大学生命科学学院,生物化学专业,本科; ●2002.9~2007.6, 四川大学生命科学学院,生物化学与分子生物学专业,博士;

工作经历

2007.7~2008.9, 中国科学院成都生物研究所,环境与微生物研究中心,助理研究员; ●2008.10~2012.10, University of Kentucky College of Medicine, Department of Molecular and Cellular Biochemistry, USA (美国肯塔基大学医学院,分子与细胞生物化学系),Postdoctoral Scholar (博士后); ●2012.11~2014.6,University of Kentucky College of Medicine, Department of Molecular and Cellular Biochemistry, USA (美国肯塔基大学医学院,分子与细胞生物化学系),Research Associate (助理研究员); ●2014.7~至今,西南交通大学生命科学与工程学院,副教授(海外引进人才)。

项目课题经历

1.教育部新世纪人才资助计划(No. NCET-04-0861):“重要抗肿瘤蛋白结构与功能研究”;(主研,2004-2007) 2.中国科学院知识创新工程重要方向项目:“真菌灰葡萄孢霉脱落酸生物合成分子机制研究”;(子课题主持,2007-2009) 3.美国国立卫生院(NIH)R01:“Sphingolipids in Cellular Signaling: Roles of Sphingolipids in aging” (PI: Robert C. Dickson, UK);(主研,2009-2013) 4.美国国立卫生院(NIH)R01:“The Regulation of Eukaryotic Gene Expression: Regulation and function of the yeast homolog RNase III” (PI: Guillaume F. Chanfreau, UCLA);(合作主研,2009-2013) 5.西南交通大学海外引进人才科研启动项目(No. 2682014RC14):“抗衰老活性分子的筛选及鉴定”;(主持,2014.01-2015.12) 6.成都市科技局科技惠民项目(No. 2015-HM01-00047-SF):“两种抗衰老药物协同效应延缓衰老的应用”;(主持,2015.10-2017.10) 7.中央高校科技创新项目(No. 2682016CX099):“抗衰老药物多球壳菌素和雷帕霉素协同作用对细胞转录组的影响及其作用靶基因的鉴定”;(主持,2016.01-2017.12) 8.四川省科技厅应用基础研究项目(No. 2016JY0113):“两种抗衰老药物协同作用延缓细胞衰老的分子机制及应用研究”;(主持,2016.01-2018.12) 9.成都市高新区“高新人才计划”创业启动项目(No. 2016113):“一种新型抗衰活性剂的研发”;(主持,2016.07-2019.07)

论文、成果、著作等

近年来在国内外学术刊物上共计发表相关论文30余篇(其中SCI论文16篇),其中代表性研究成果发表在Cell Metabolism(2012)(IF=19.02), PLoS Genetics(2012)(IF=10.05),Aging Cell(2013)(IF=7.12), Biochim Biophys Acta(2014)(IF=4.89), PLoS One(2015)(IF=4.02), EMIR (2016) (IF=3.50), Chemosphere(2017)(IF=4.2)等国际知名期刊上,SCI论文总影响因子超70,他引超400次。近期代表性论文(2012-2017):(注:#共同第一作者;*通讯作者.) 1.Xinhe Huang, Jun Liu, Robert C. Dickson*. Down-regulating sphingolipid synthesis increases yeast lifespan. PLoS genetics 8, e1002493. (2012) 2.Yueh-Jung Lee, Xinhe Huang, Janette Kropat, Anthony Henras, Sabeeha S. Merchant, Robert C. Dickson*, Guillaume F. Chanfreau, Sphingolipid signaling mediates iron toxicity. Cell metabolism 16, 90-96. (2012) 3.Xinhe Huang, Jun Liu, Bradley R. Withers, Aaron J. Samide, Markos Leggas, Robert C. Dickson*. Reducing signs of aging and increasing lifespan by drug synergy. Aging cell 12, 652-660. (2013) 4.Jun Liu, Xinhe Huang, Bradley R. Withers, Eric Blalock, Ke Liu, Robert C. Dickson*. Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan. Aging cell 12, 833-841. (2013) 5.Xinhe Huang, Bradley R. Withers, Robert C. Dickson*. Sphingolipids and lifespan regulation. Biochimica et biophysica acta 1841, 657-664. (2014) 6.Xinhe Huang*, Markos Leggas, Robert C*. Dickson. Drug synergy drives conserved pathways to increase fission yeast lifespan. PloS one 10, e0121877. (2015) 7.Zubi Liu, Qiankun Zhu, Juanjuan Li, Jihua Yu, Yangyang Li, Xinhe Huang, Wanjun Wang, Rui Tan, Jiayu Zhou*, Hai Liao*. Selection and evaluation of reference genes for expression analysis of Cassi. Bioscience, biotechnology, and biochemistry 79, 1818-1826. (2015) 8.Juanjuan Li, Gan Zhang, Jihua Yu, Yangyang Li, Xinhe Huang, Wanjun Wang, Rui Tan, Jiayu Zhou*, Hai Liao*. Molecular cloning and characterization of caffeic acid 3-O-methyltransferase from the rhizome of Ligusticum chuanxiong. Biotechnology letters 37, 2295-2302. (2015) 9.Xinhe Huang, Yuxing Li, Jingmei Pan, Ming Li, Yongqin Lai, Jie Gao, Xueru Li*. RNA-Seq identifies redox balance related gene expression alterations under acute cadmium exposure in yeast. Environmental microbiology reports 8, 1038-1047. (2016) 10.Jihua. Yu, Yangyang Li, Mian Xiang, Jianquan Zhu, Xinhe Huang, Wanjun Wang, Rui Tan, Jihua Zhou, Hai Liao. Molecular cloning and characterization of alpha-amylase/subtilisin inhibitor from rhizome of Ligusticum chuanxiong. Biotechnology letters 39, 141-148. (2017) 11.Shuquan Rao, Yao Yao, Joanne Ryan, Chunhui Jin, Yong Xu, Xinhe Huang, Jianxiu Guo, Yueqiang Wen, Canquan Mao, David Meyre, Fuquan Zhang. Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations. Scientific reports 7, 41140. (2017) 12.Jingmei Pan# , Xinhe Huang#, Yuxing Li, Ming Li, Ning Yao, Zhengdong Zhou, Xueru Li*. Zinc protects against cadmium-induced toxicity by regulating oxidative stress, ions homeostasis and protein synthesis. Chemosphere, in press. (2017) 参编著作/教材: ● 参编“十一五”国家级规划教材《生物化学原理》(张洪渊 主编,刘克武,孟延发 副主编)。北京:科学出版社,ISBN: 7-03-017680-4. ● 参编《基因工程》(双语教材)(茆灿泉 主编,黄新河,廖海,熊莉丽 参 编)。成都:西南交通大学出版社,2016. 学术会议/报告: 1.中国科学院百人学者学术年会,大会报告:“真菌灰葡萄孢酶(Botrytis cinerea)生物合成脱落酸的转录组及蛋白组研究”;(云南,西双版纳,2007.10) 2.University of Kentucky College of Medicine 2010 Annual Research Conference, “Down-regulating Sphinglipids Extends Yeast Lifespan” (Presentation) (肯塔基大学医学院2010学术年会,学术报告:“下调神经鞘脂延长酵母细胞寿命”);(美国,列克星敦,2010.06) 3.University of Kentucky College of Medicine 2011 Annual Research Conference, “Extending Lifespan by Modulating Sphingolipids in Yeast” (Presentation) (肯塔基大学医学院2011学术年会,学术报告:“神经鞘脂在寿命调控中的作用”);(美国,列克星敦,2011.06) 4.University of Kentucky College of Medicine 2012 Annual Research Conference, “Modulating Sphingolipids to Prevent Age-related Diseases and Increase Lifespan” (Presentation) (肯塔基大学医学院2012学术年会,学术报告:“神经鞘脂在延缓衰老及减少衰老相关疾病发生过程中的调控作用”) ;(美国,列克星敦,2012.06) 5.University of Kentucky College of Medicine 2013 Annual Research Conference, “Can Aging and Lifespan Be Controlled by Drugs?” (Presentation) (肯塔基大学医学院2013学术年会,学术报告:“衰老及寿命可以被药物小分子调控吗?”) ;(2013年6月,美国,列克星敦) 6.2015年四川省青年科学家“生命科学新进展”学术交流会,大会报告:“药物协同作用延缓衰老的理论及应用”;(四川,成都,2015.01) 7.生物医药前沿国际会议,分会报告:“Modulating sphingolipids extends lifespan of yeast”;(四川,成都,2015.05) 8.第19届中国生命科学院长论坛(甘肃,兰州,2015.09) 9.四川省免疫学会年会(四川,成都,2016.01) 10.四川省细胞生物学学会年会(i)(四川,南充,2016.04) 11.2016年四川省青年科学家“生命科学新进展”学术交流会,大会报告:“Down-regulation of sphingolipids extends lifespan of fission yeast”;( 四川,成都,2016.06) 12.2016年全国老年基础与转化医学大会(江西,南昌,2016.11) 13.四川省细胞生物学学会年会(ii),分会报告:“Can lifespan be extended by drugs?”;(四川,成都,2016.12) 14.第十届中国模式真菌会议,分会报告:“Modulating Sphingolipids to Increase Lifespan in Multiple Organisms”;(兼任大会组委会秘书,四川,成都,2017.06)

专利、著作版权等

声明:本站专家信息来源于各高校官网。