四川大学生物治疗国家重点实验室博士毕业

宾夕法尼亚大学医学院博士后。2003-2005年在军事医学科学院生物工程研究所从事课题研究工作。

目前主持主研国家级项目7项，其中国家自然科学基金6项，科技部项目1项。主研横向项目2项。1. 国家自然科学基金项目：“肝癌中p53直接调控microRNA及其靶基因的筛选与调控机制研究”（31200999） 2. 科技部项目：“民族药用生物标本关键信息整理与共享”（2012S31001） 3. 国家自然科学基金项目：“极化的QM/MM方法及在DNA碱基质子迁移和电荷转移中的应用”（10974161） 4. 国家自然科学基金项目：“针刺促进脊髓可塑性中microRNA124的作用及其对PDXK的调控”（81271358） 5. 国家自然科学基金项目: “自结合肽的结构生物信息分析及相关新方法研究”（31200993） 6. 国家自然科学基金项目: “NAC家族转录因子特异基因对铁皮石斛原球茎发生的分子机理研究”（31271302） 7. 国家自然科学基金项目: “三个藏药经典方早中晚组合给药协同治疗脑缺血机制探讨／H2818”（81274184） 8. 教育部中央财政专项基金创新项目：“p53信号通路microRNA及其靶基因在肝癌中的筛选与验证” (SWJTU12CX050) 9. 教育部中央财政专项基金项目：“荧光素酶报告系统检测p53与MicroRNA 101-2、29a的相互作用位点”（SWJTU09BR217） 10.西南交通大学青年教师科研起步计划项目：“p53直接调控microRNA及其靶基因的筛选”. （2009Q051） 11.横向项目：“农村供水和环境卫生项目环境管理监测”（2009H01292） 12.横向项目：WERP环境管理计划外部监测（2012H01053）

在国际期刊发表多篇SCI论文。* Ran Kang, Yiming Zhang, Qingqing Huang, Junhua Meng, Ruofan Ding, Yunjian Chang, Lili Xiong, Zhiyun Guo*, EnhancerDB: A Resource of Transcriptional Regulation in the Context of Enhancers, Database (Oxford). 2019.doi: 10.1093/database/bay141 * Liu W, Huai R, Zhang Y, Rao S, Xiong L, Ding R, Mao C, Zhao W, Hao T, Huang Q, Guo Z*.Down-regulation expression of TGFB2-AS1 inhibits the proliferation, migration, invasion and induces apoptosis in HepG2 cells. Genes Genomics. 2019 ，41(8):951-959 * Wenrong Liu#, Ruiping Huai,Yin Zhang, Shuquan Rao, Lili xiong, Ruofan Ding, Canquan Mao, Wenqing Zhao, Tao Hao, Qingqing Huang, Zhiyun Guo*, Down-regulation expression of TGFB2-AS1 inhibits the proliferation, migration, invasion and induces apoptosis in HepG2 cells.Genes & Genomics (2019) 41:951–959 * Xiong LL#, Kang R, Ding RF, Kang WY, Zhang YM, Liu WR, Huang QQ, Meng JH, Guo ZY*, Genome-wide Identification and Characterization of Enhancers Across 10 Human Tissues, Int J Biol Sci. 2018 Jul 27;14(10):1321-1332. * An APOE-independent cis-eSNP on chromosome 19q13.32 influences tau levels and late-onset Alzheimer's disease risk，Neurobiol Aging, 2018,17. Joint first authors. (SCI) * Identification and Analysis of P53-Mediated Competing Endogenous RNA Network in Human Hepatocellular Carcinoma，INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2017,13(9): 1213~1221.(SCI) * A novel peptide, 9R-P201, strongly inhibits the viability, proliferation and migration of liver cancer HepG2 cells and induces apoptosis by down-regulation of FoxM1 expression，EUROPEAN JOURNAL OF PHARMACOLOGY, 2017, 796: 175~189 .Co-corresponding author.(SCI) * Peripheral blood nerve growth factor levels in major psychiatric disorders，JOURNAL OF PSYCHIATRIC RESEARCH, 2017, 86: 39~45.(SCI) * Transcriptome profiling analysis of differentially expressed mRNAs and lncRNAs in HepG2 cells treated with peptide 9R-P201，BIOTECHNOLOGY LETTERS, 2017.39(11): 1639~1647.(SCI) * 肝癌细胞HepG2中p53调控miRNA-3661的生物信息分析与功能验证，生物技术通报, 2017.6.7, (07): 216~223 * 肝癌细胞HepG2中增强子的识别及生物信息学分析，生物技术通讯, 2017.7.30, (04): 455~459 * 抗肿瘤多肽9R-P201诱导下的肝癌HepG2细胞转录组测序分析，生物技术通报, 2017.4.21, (07): 210~215 * The ACEII recombinant Trichoderma reesei QM9414 strains with enhanced xylanase production and its applications in production of xylitol from tree barks.MICROBIAL CELL FACTORIES, 2016,15.(SCI) * Comprehensive Expression Profiling and Functional Network Analysis of p53-Regulated MicroRNAs in HepG2 Cells Treated with Doxorubicin.PLoS One. 2016 Feb 17;11(2):e0149227.(SCI) * Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues.Scientific Repoorts. 2014 Jun 3;4:5150. doi: 10.1038/srep05150.(SCI) * Identification and analysis of the regulatory network of Myc and microRNAs from high-throughput experimental data. Computers in Biology and Medicine. 2013, 43(9):1252-1260 (SCI) * Salidroside improves Doxorubicin-Induced cardiac dysfunction by Suppression of Excessive Oxidative Stress and Cardiomyocyte Apoptosis: Doxorubicin Cardiotoxicity inhibited by Salidroside. J Cardiovasc Pharmacol. 2013, 2013, 62(6):512-23 (SCI) * Molecular mechanism of Hepatocellular Carcinoma-Specific antitumor activity of novel thienopyridine derivative TP58. Oncology reports. 2012, 28(1):225-31(SCI) * Ghrelin protects against cobalt chloride-induced hypoxic injury in cardiac H9c2 cells by inhibiting oxidative stress and inducing autophagy. Peptides. 2012, 38(2):217-227 (SCI) * Molecular evolution of candidate sour taste receptor gene PKD1L3 in mammals. Genome. 2011,54(11):890-7 (SCI) * Disruption of CD38 gene enhances cardiac functions by elevating serum testosterone in the male null mice.Life Sci. 2011, 89(13-14):491-497 (SCI) * 基于EST和GSS 序列的玉米未知微RNA 的挖掘.生物技术通报. 2011, 12:108-112 (核心) * α-synuclein：Gene structure，evolution and in vitro protein aggregation. Neural Regeneration Research, 2010,5(18)：1423-1428 (SCI) * The High Throughput Screening of p53 Direct Regulatory microRNA and Their Target Genes. Prog Biochem Biophys. 2009 36(9):1154-1164 (SCI) 会议论文 *Genome-wide identification and analysis expression profile of p53-regulated microRNAs in hepatic carcinoma by small RNA sequencing, Festival of Genomics, 美国，波士顿, 2015.6.22-2015.6.24 * Bioinformatics and bacterial display of human alpha synuclein proteins,21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology, August 2-7,2009,Shanghai,China. P179.

长链非编码RNA RP11-224O19.2抑制剂的用途，中国专利, 申请, 2017.7.11, 专利申请号：201710392888.2 * 一种竞争性内源RNA网络的识别方法,中国专利, 申请, 2017.9.12, 专利申请号：201710412094.7 * The human Tissue-specific Enhancer Database software，软件著作权号：2017SR475379, 2017.8.29 * Tissue-specific miRNA dࣺᯬ