教育背景
工作经历
项目课题经历
西南交通大学“扬华学者”高层次人才计划,2019/06-2022/06,45万,主持。
西南交通大学优青培育项目,2018/03-2019/03,15万,主持。
新世纪、教育部创新团队项目,2017/03-2018/03,10万,主持。
四川省青年科技基金--杰出青年资助计划(项目号:2016JQ0027),2016/01-2019/12,50万,主持。
西南交通大学“雏鹰学者”高层次人才计划,2015/09-2018/09,30万,主持。
国家自然科学基金--面上项目(项目号:31570957),2016/01-2019/12,73.2万,主持。
国家自然科学基金--青年科学基金项目(项目号:81501596),2016/01-2018/12,21.6万,主持。
中央高校基本科研业务费专项资金医学类专题研究项目(项目号:2682015YXZT07),2015/7-2017/7,10万,主持。
西南交通大学引进人才项目(项目号:2682015RC21),2015.05-2016.10, 15万,主持。
论文、成果、著作等
学术论文
目前,在Chemistry of Materials, NPG Asia Materials, Biomaterials, Applied Materials Today, ACS Applied Materials and Interfaces, Acta Biomaterialia, Advanced Healthcare Materials等国际期刊上共发表三大检索收录论文40余篇,其中以第一作者身份(通讯作者)在SCI收录杂志上发表30余篇(平均影响因子>6),论文被60余种SCI源期刊总引用1000余次,单篇最高他人引用150余次。申请专利14项(包括国际专利1项),其中授权的10项。(注:* 表示通讯作者,1表示共同第一作者)
第一及通讯作者论文
2020
37. Tong Yang, Zeyu Du, Hua Qiu, Peng Gao, Xin Zhao, Huaiyu Wang, Qiufen Tu, Kaiqin Xiong, Nan Huang, Zhilu Yang*. From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading. Bioactive Materials. 2020.doi.org/10.1016/j.bioactmat.2019.12.006
36.Qiufen Tu1, Xin Zhao1, Shuai Liu, Xiangyang Li, Qiang Zhang, Han Yu, Kaiqin Xiong, Nan Huang, Zhilu Yang*. Spatiotemporal Dual-Delivery of Therapeutic Gas and Growth Factor for Prevention of Vascular Stent Thrombosis and Restenosis. Applied Materials Today. 2020. doi.org/10.1016/j.apmt.2019.100546 (IF: 8.013)
2019
35. Donghai Yu, Xiaohui Mou, Zhenglong Dou, Ningling Zhou, Qianru Guo, Nan Lv, Lei Lv, Zhilu Yang*, Nan Huang*. “One-pot but Two-step” Vapor-based Amine- and Fluorine-bearing Dual-layer Coating for Improving Anti-corrosion and Biocompatibility of Magnesium Alloy. ACS Biomaterials Science & Engineering. 2019;5:4331-4340.
34. Feng Qiao, Qianru Guo, Qiufen Tu, Jing Lu, Jin Wang, Wenjie Tian*, Kaiqin Xiong*, Nan Huang and Zhilu Yang*. Photolithography-Mediated Area-Selective Immobilization of Biomolecules on Polydopamine Coating. Langmuir. 2019; 35:7175-7179.
33. Hua Qiu1, Pengkai Qi1, Xing Tan, Yu Xiao, Jingxia Liu, Lei Lu, Peng Gao, Ying Yang, Nan Huang*, Zhilu Yang*. Biomimetic Engineering Endothelium-like Coating on Cardiovascular Stent through Heparin and Nitric Oxide-Generating Compound Synergic Modification Strategy. Biomaterials. 2019;207:10-22. (IF: 10.273)
32. Qiufen Tu1, Xuehong Shen1, Yaowen Liu, Qiang Zhang, Xin Zhao, Manfred F. Maitz, Tao Liu, Hua Qiu, Jin Wang, Nan Huang*, Zhilu Yang*. A facile metal-phenolic-amine strategy for dual-functionalization of blood-contacting devices with antibacterial and anticoagulant properties. Materials Chemistry Frontiers. 2019;3:265-275.
31. Feng Zhang1, Qiang Zhang1, Xiangyang Li, Nan Huang, Xin Zhao*, Zhilu Yang*. Mussel-inspired dopamine-CuII coatings for sustained in situ generation of nitric oxide for prevention of stent thrombosis and restenosis. Biomaterials. 2019;194:117-129.(IF: 10.273)
2018
30. Xiangyang Li, Peng Gao, Jianying Tan, Kaiqin Xiong, Changjiang Pan, Hongkai Wu, Yin Chen, Zhilu Yang*, Nan Huang*. Assembly of Metal-Phenolic/Catecholamine Networks for Synergistically Anti-Inflammatory, Antimicrobial and Anticoagulant Coatings. ACS Applied Materials & Interfaces. 2018;10:40844-40853.(IF: 8.456)
29. Zhilu Yang*, Ying Yang, Kaiqin Xiong, Jin Wang, Haeshin Lee*, Nan Huang*, Metal-Phenolic Surfaces for Generating Therapeutic Nitric Oxide Gas. Chemistry of Materials.2018;30:5220-5226.(IF: 10.159)
28. Zhilu Yang*, Ying Yang, Li Zhang, Kaiqin Xiong, Xiangyang Li, Feng Zhang, Jin Wang, Xin Zhao*, Nan Huang*, Mussel-inspired Catalytic Selenocystamine-Dopamine Coatings for Long-Term Generation of Therapeutic Gas on Cardiovascular Stents. Biomaterials. 2018;178:1-10.(IF: 10.273).
27. Zhilu Yang*, Hua Qiu, Xiangyang Li, Peng Gao, Nan Huang*, Plant-inspired gallolamine catalytic surface chemistry for engineering an efficient nitric oxide generating coating. Acta Biomaterialia. 2018;76:89-98.(IF: 6.638).
26. Xiangyang Li, Hua Qiu, Peng Gao, Ying Yang, Zhilu Yang*, Nan Huang*, Synergetic coordination- and catecholamine chemistry for catalytic generation of nitric oxide on vascular stents. NPG Asia Materials. 2018;10:482–496.(IF: 8.052)
25. Ying Yang, Xiangyang Li, Hua Qiu, Ping Li, Manfred F. Maitz, Tianxue You, Ru Shen, Zhilu Yang*, Wenjie Tian*, and Nan Huang*. Polydopamine modified TiO2 nanotube arrays for long term controlled elution of bivalirudin and improved hemocompatibility. ACS Applied Materials & Interfaces. 2018;10:7649−7660.(IF: 8.456)
2017-2015
24. Pengkai Qi, Ying Yang, Sheng Zhao, Juan Wang, Xiangyang Li, Qiufen Tu*, Zhilu Yang*, Nan Huang*. Improvement of corrosion resistance and biocompatibility of biodegradable metallic vascular stent via plasma allylamine polymerized coating. Materials and Design. 2016;96:341-349.
23. Kaiqin Xiong, Pengkai Qi, Ying Yang, Xiangyang Li, Hua Qiu, Xin Li, Ru Shen, Zhilu Yang*, Qiufen Tu*, Nan Huang*. Facile immobilization of vascular endothelial growth factor on tannic acid-functionalized plasma-polymerized allylamine coating rich in quinone groups. RSC Advance. 2016;6:17188-17195.
22. Ying Yang, Pengkai Qi, Xiangyang Li, Yalong Li, Zhilu Yang*, Qiufen Tu, Nan Huang*. Development of nitric oxide catalytic coatings by Conjugating 3,3-disulfodipropionic acid and 3,3-diselenodipropionic acid for improving hemocompatibility. Biointerphases. 2015;10(4)A303-8
21. Ying Yang Pengkai Qi, Zhilu Yang*, Nan Huang*. Nitric oxide based strategies for applications of biomedical devices (Review). Biosurface and Biotribology. 2015;1(3):177-201.
20. Zhilu Yang*, Ying Yang, Kaiqin Xiong, Xiangyang Li, Pengkai Qi, Qiufen Tu, Fengjuan Jing, Yajun Weng, Jin Wang*, Nan Huang*. Nitric oxide producing coating mimicking endothelium function for multifunctional vascular stents. Biomaterials. 2015;63:80-92. (IF: 10.273).
19. Pengkai Qi, Ying Yang, Kaiqin Xiong, Qiufen Tu,Zhilu Yang*, Jin Wang, Junying Chen, Nan Huang*. Multifunctional plasma polymerized film: towards better anti-corrosion property, enhanced cellular growth ability, attenuated inflammatory and histological responses. ACS Biomaterials Science & Engineering.2015;1:513-524.
18. Pengkai Qi, Wei Yan, Ying Yang, Yalong Li, Baolong Ma, Yi Fan, Zhilu Yang*, Qiufen Tu*, Nan Huang*. Immobilization of DNA aptamers via plasma polymerized allylamine film to construct an endothelial progenitor cell-capture surface. Colloids and Surfaces B: Biointerfaces. 2015;126:70-79.
17. Ying Yang, Pengkai Qi, Yonghui Ding, Manfred F. Maitz, Zhilu Yang*, Qiufen Tu, Kaiqin Xiong, Yang Leng, Nan Huang*. A biocompatible and functional adhesive amine-rich coating based on dopamine polymerization. Journal of Materials and Chemistry: B. 2015;3:72-81.
Before PI (2014-2009)
16. Zhilu Yang*, Si Zhong, Ying Yang, Manfred F. Maitz, Xiangyang Li, Qiufen Tu, Pengkai Qi, Heng Zhang, Hua Qiu, Jin Wang, Nan Huang. Polydopamine-mediated long-term elution of the direct thrombin inhibitor bivalirudin from TiO2 nanotubes for improved vascular biocompatibility. Journal of Materials and Chemistry: B. 2014;2:6767-6778.
15. Zhilu Yang*, Kaiqin Xiong, Pengkai Qi, Ying Yang, Qiufen Tu, Jin Wang*, Nan Huang*. Gallic acid tailoring surface functionalities of plasma-polymerized allylamine-coated 316L SS to selectively direct vascular endothelial and smooth muscle cell fate for enhanced endothelialization. ACS Applied Materials & Interfaces. 2014;6:2647-2656. (IF: 8.456)
14. Ying Yang, Pengkai Qi, Feng Wen, Xiangyang Li, Qin Xia, Manfred F. Maitz, Zhilu Yang*, Ru Shen, Qiufen Tu, Nan Huang*. Mussel-inspired one-step adherent coating rich in amine groups for covalent immobilization of heparin: hemocompatibility, growth behaviors of vascular cells and tissue response. ACS Applied Materials & Interfaces. 2014;6:14608-14620. (IF: 8.456)
13. Pengkai Qi, Ying Yang, Xiangyang Li, Ru Shen, Jin Wang, Zhilu Yang*, Qiufen Tu*, Nan Huang*. Constructing biomimic catalytic coating with controlled nitric oxide release properties by immobilizing 3,3-diselenodipropionic acid on plasma polymerized allylamine film. Plasma Processes and Polymers. 2014;10:952-960.
12. Zhilu Yang1,*, Ying Yang1,Wei Yan, Qiufen Tu*, Jin Wang*, Nan Huang. Construction of polyfunctional coatings assisted by gallic acid to facilitate co-immobilization of diverse biomolecules. ACS Applied Materials & Interfaces. 2013;5:10495-10501. (IF: 8.456)
11. Zhilu Yang*, Qiufen Tu*, Manfred F. Maitz, Shou Zhou, Jin Wang, Nan Huang*. Direct thrombin inhibitor-bivalirudin functionalized plasma polymerized allylamine coating for improved biocompatibility of vascular devices. Biomaterials. 2012;33:7959-7971. (IF: 10.273)
10. Zhilu Yang, Qiufen Tu, Ying Zhu, Rifang Luo, Xin li, Yichu Xie, Manfred F. Maitz, Jin Wang*, Nan Huang*. Mussel-inspired coating of polydopamine directs endothelial and smooth muscle cell fate for re-endothelialization of vascular devices. Advanced Healthcare Materials. 2012;1:548-559.(IF: 6.270)
9. Zhilu Yang*, Qiufen Tu, Jin Wang*, Nan Huang*. The role of heparin binding surface in the direction of endothelial and smooth muscle cell fate and re-endothelialization. Biomaterials. 2012;33:6615-6625. (IF: 10.273)
8. Zhilu Yang1, Shuo Zhou1, Lei Lu, Xin Wang, Jin Wang*, Nan Huang*. Construction and hemocompatibility study of highly bioactive heparin-functionalized surface. Journal of Biomedical Materials Research: Part A. 2012;100A:3124-3133.
7. Zhilu Yang, Jing Wu, Xin Wang, Jin Wang*, Nan Huang*. Inspired chemistry for a simple but highly effective immobilization of vascular endothelial growth factor on gallic acid-functionalized plasma polymerized film. Plasma Processes and Polymers. 2012;9:718-725.
6. Zhilu Yang, Jin Wang*, Xin Li, Qiufen Tu, Hong Sun, Nan Huang. Interaction of platelets, fibrinogen and endothelial cells with plasma deposited PEO-like films. Applied Surface Science. 2012;258:3378-3385.
5. Zhilu Yang, Jin Wang*, Rifang Luo, Tingting He, Si Chen, Xingjiang Lei, Hong Sun, Nan Huang. Improved hemocompatibility guided by pulsed plasma tailoring the surface amino functionalities of TiO2 coating for covalent immobilization of heparin. Plasma Processes and Polymers. 2011;8:850-858.
4. Zhilu Yang, Qiufen Tu, Jin Wang*, Xingjiang Lei, Tingting He, Hong Sun, Nan Huang. Bioactive plasma-polymerized bipolar films for enhanced endothelial cellular mobility. Macromolecular Bioscience. 2011;11:797-805.
3. Zhilu Yang, Xingjiang Lei, Jin Wang*, Rifang Luo, Tingting He, Hong Sun, Nan Huang. A novel technique toward bipolar films containing alternating nano–layers of allylamine and acrylic acid plasma polymers for biomedical application. Plasma Processes and Polymers. 2011;8:208-214. (封面)
2. Zhilu Yang, Jin Wang*, Rifang Luo, Manfred F. Maitz, Fengjuan Jing, Hong Sun, Nan Huang. The covalent immobilization of heparin to pulsed-plasma polymeric allylamine films on 316L stainless steel and the resulting effects on hemocompatibility. Biomaterials. 2010;31:2072–2083. (IF: 10.273)
1. Zhilu Yang, Xiaona Wang, Jin Wang*, Ye Yao, Hong Sun, Nan Huang. Pulsed plasma polymeric allylamine thin films. Plasma Processes and Polymers. 2009;6:498-505.
合著论文
10. Yonghui Ding, Meng Yang, Zhilu Yang, Rifang Luo, Xiong Lu, Nan Huang, Pingbo Huang, Yang Leng. Cooperative control of blood compatibility and re-endothelialization by immobilized heparin and substrate topography. Acta Biomaterialia. 2015.
9. Yonghui Ding, Lu-Tao Weng, Meng Yang, Zhilu Yang, Xiong Lu, Nan Huang, Yang Leng. Insights into aggregation/depositionand structure of polydopamine film. Langmuir. 2014;30:12258-12269.
8. Yonghui Ding, Zhilu Yang, Cathy WC Bi, Meng Yang, Jingcheng Zhang, Sherry Li Xu, Xiong Lu, Nan Huang, Pingbo Huang, Yang Leng. Modulation of protein adsorption, vascular cell selectivity and platelet adhesionby mussel-inspired surface functionalization. Journal of Materials and Chemistry: B. 2014;2:3819-3829.
7. Yonghui Ding, Zhilu Yang, Cathy W. C. Bi, Meng Yang, Sherry Li Xu, Xiong Lu, Nan Huang, Pingbo Huang, Yang Leng. Directing vascular cell-selectivity and hemocompatibility on patterned platforms featuring variable topographic geometry and size. ACS Applied Materials & Interfaces. 2014;6:12062-12070.
6. Pengkai Qi, Si Chen, Tao Liu, Jialong Chen, Zhilu Yang, Yajun Weng, Junying Chen, Jin Wang, Manfred F. Maitz, Nan Huang. New strategies for developing cardiovascular stent surfaces with novel functions (Review). Biointerphases. 2014;9:1-13.
5. Si Chen, Xin Li, Zhilu Yang, Shuo Zhou, Rifang Luo, Manfred F. Maitz, Yuanchong Zhao, Jin Wang. Kaiqin Xiong, Nan Huang. A simple one-step modification of various materials for introducing effective multi-functional groups. Colloids and Surfaces B: Biointerfaces. 2013;113:125-133.
4. Rifang Luo, Linlin Tang, Si Zhong, Zhilu Yang, Jin Wang, Yajun Weng, Qiufen Tu, Chongxi Jiang, Nan Huang. In vitro investigation of enhanced hemocompatibility and endothelial cell proliferation associated with quinone-rich polydopamine coating. ACS Applied Materials & Interfaces. 2013;5:1704-1714.
3. Qiufen Tu, Zhilu Yang, Ying Zhu, Kaiqin Xiong, Manfred F. Maitz, Jin Wang, Yuancong Zhao, Nan Huang, Jian Jin, Yuechang Lei. Effect of tissue specificity on the performance of extracellular matrix in improving endothelialization of cardiovascular implants. Tissue Engineering: Part A. 2013;19:91-102.
2. Tingting He, Zhilu Yang, Rui Chen, Jin Wang, Yongxiang Leng, Hong Sun, Nan Huang. Enhanced endothelialization guided by fibronectin functionalized plasma polymerized acrylic acid film. Materials Science and Engineering: C. 2012;32:1025-1031.
1. Xiaona Wang, Jin Wang, Zhilu Yang, Yongxiang Leng, Hong Sun, Nan Huang. Structural characterization and mechanical properties of functionalized pulsed-plasma polymerized allylamine film. Surface and Coatings Technology. 2010;204:3047-3052.
专利、著作版权等
发明专利
14. 杨志禄,黄楠,王进,翁亚军,一种构建一氧化氮催化型粘附涂层的方法,国际专利申请号:PCT/CN2015/086773。
13. 王进,罗日方,杨志禄,黄楠,翁亚军,冷永祥,赵元聪,一种具有诱导催化内源性NO释放功能的抗凝血材料制备方法,授权时间2015年11月25日,中国,发明专利号ZL201410394981.2。
12. 王进,杨志禄,黄楠,冷永祥,赵元聪,一种具有高生物功能性的肝素化界面材料制备方法,授权时间2013年7月31日,中国,发明专利号ZL201110195704.ࣺᯬ
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