2002.09‒2006.07 西南大学生物工程系 （导师：潘国庆 教授） 学 士 2006.09‒2008.07 华中科技大学生物医学工程系（导师：张胜民/万影 教授） 硕 士 2008.09‒2011.07 华中科技大学生物医学工程系（导师：张胜民 教授） 博 士

2011.09‒2014.09 美国佐治亚州立大学生物医学科学研究院 博士后 2014.09‒2017.06 西南大学 副教授 2017.07至今 西南大学 教 授

先后主持国家自然科学基金（面上基金、青年基金）、中央高校基本业务费人才团队项目（优青）、重庆市青年拔尖人才项目、重庆市留学人员创业创新支持计划（优秀类）、美国心脏协会（American Heart Association）研究基金等多项科研项目

代表性论文/论著（*通讯作者）： 1. Gou S., Huang Y., Wan Y., Ma Y., Zhou X., Tong X., Huang J.*, Kang Y.*, Pan G., Dai F., Xiao B.*. Multi-bioresponsive silk fibroin-based nanoparticles with on-demand cytoplasmic drug release capacity for CD44-targeted alleviation of ulcerative colitis. Biomaterials 2019; 212:39-54. 2. Xiao B. ,*, Viennois E., Chen Q., Wang L., Han M., Zhang Y., Zhang Z., Kang Y., Wan Y., Merlin D. Silencing of Intestinal Glycoprotein CD98 by Orally Targeted Nanoparticles Enhances Chemosensitization of Colon Cancer. ACS nano 2018;12:5253-5265. 3. Xiao B.,*, Chen Q., Zhang Z., Wang L., Denning T., Kang Y., Merlin D. TNFα gene silencing mediated by orally targeted nanoparticles combined with interleukin-22 for synergistic combination therapy of ulcerative colitis. Journal of Controlled Release 2018;287:235-246. 4. Xiao B.*, Zhang M., Viennois E., Zhang Y., Wei N., Baker M.T., Jung Y., Merlin D. Inhibition of MDR1 gene expression and enhancing cellular uptake for effective colon cancer treatment using dual-surface-functionalized nanoparticles. Biomaterials 2015;48:147-160. 5. Xiao B.*, Laroui H., Viennois E., Ayyadurai S., Charania M.A., Zhang Y., Zhang Z., Baker M.T., Zhang B., Gewirtz A.T., Merlin D.. Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice. Gastroenterology 2014; 146(5):1289-1300. 6. Zhang X., Ma Y., Ma L., Zu M., Song H., Xiao B.* Oral administration of chondroitin sulfate-functionalized nanoparticles for colonic macrophage-targeted drug delivery. Carbohydrate Polymers 2019;223:115126-34. 7. Gou S., Huang Y., Sung J., Xiao B.*, Merlin D. Silk fibroin-based nanotherapeutics: application in the treatment of colonic diseases. Nanomedicine (Lond) 2019. Doi: 10.2217/nnm-2019-0058. 8. Ma P., Gou S., Ma Y., Chen Q., Zhu S., Chen J.*, Kang Y., Xiao B.* Modulation of drug release by decoration with Pluronic F127 to improve anti-colon cancer activity of electrospun fibrous meshes. Materials Science & Engineering C 2019;99:591-598. 9. Gou S., Chen Q., Liu Y., Zeng L., Song H., Xu Z., Kang Y.*, Li C., Xiao B.*. Green Fabrication of Ovalbumin Nanoparticles as Natural Polyphenol Carriers for Ulcerative Colitis Therapy. ACS Sustainable Chem. Eng. 2018;6(10): 12658-12667. 10. Xiao B.*, Xu Z., Viennois E., Zhang Y., Zhang Z., Zhang M., Han M., Kang Y., Merlin D. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Molecular Therapy 2017;25(5):1628-1640. 11. Xiao B.*, Ma L., Merlin D. Nanoparticle-mediated co-delivery of chemotherapeutic agent and siRNA for combination cancer therapy. Expert Opinion on Drug Delivery 2017;14:65-73. 12. Ma L., Chen Q., Ma P., Han M., Xu Z., Kang Y.*, Xiao B.*, & Merlin D.. iRGD-functionalized PEGylated nanoparticles for enhanced colon tumor accumulation and targeted drug delivery. Nanomedicine 2017;12(16):1991-2006. 13. Xiao B.*, Ma P., Ma L., Chen Q., Si X., Walter L., Merlin D. Effects of tripolyphosphate on cellular uptake and RNA interference efficiency of chitosan-based nanoparticles in Raw 264.7 macrophages. Journal of Colloid and Interface Science 2017;490: 520-528. 14. Xiao B.*, Zhang Z., Viennois E., Kang Y., Zhang M., Han M.K., Chen J., Merlin D. Combination Therapy for Ulcerative Colitis: Orally Targeted Nanoparticles Prevent Mucosal Damage and Relieve Inflammation. Theranostics 2016;6:2250-2266. 15. Xiao B.*, Han M. K., Viennois E., Wang L., Zhang M., Si X., Merlin D. Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy. Nanoscale 2015;7:17745-55. 16. Xiao B.*, Si X., Han M.K., Viennois E., Zhang M., Merlin D. Co-delivery of camptothecin and curcumin by cationic polymeric nanoparticles for synergistic colon cancer combination chemotherapy. Journal of Materials Chemistry B 2015;3:7724-7733. 17. Xiao B.*, Yang Y., Viennois E., Zhang Y., Ayyadurai S., Baker M., Laroui H., Merlin D. Glycoprotein CD98 as a receptor for colitis-targeted delivery of nanoparticle. Journal of Materials Chemistry B 2014;2(11):1499-1508. 18. Xiao B.*, Laroui H., Ayyadurai H., Viennois E., Charania M.A., Zhang Y., Merlin D. Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy. Biomaterials 2013;34(30):7471-82. 19. Xiao B.*, Merlin D. Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease. Expert Opinion on Drug Delivery 2012, 9(11):1393-407. 20. Xiao B., Wan Y., Zhao M., Liu Y., Zhang S.* Preparation and characterization of antimicrobial chitosan-N-arginine with different degrees of substitution. Carbohydrate Polymers 2011;83: 144-150.

申请美国专利2项（授权1项）、中国专利10余项