近年来承担的科研项目： {C}1) {C}国家重点研发计划子课题：生防真菌穿透宿主昆虫体壁的作用机理和生防真菌逃避昆虫免疫反应的分子机制研究（2017YFD0200400，2017-2020）主持 {C}2) {C}国家自然科学基金：虫菌体特异表面蛋白与球孢白僵菌逃避昆虫免疫识别的关系及作用机制 (31672080, 2017-2020) 主持 {C}3) {C}国家自然科学基金：负调节球孢白僵菌氧化胁迫反应的Bbtmp1基因转录调控子鉴定及其调控作用 (31371993, 2014-2017) 主持 {C}4) {C}重庆市基础科学与前沿技术研究重点项目：Bbmpk1-Bbste12 途径调控球孢白僵菌穿透昆虫体壁（cstc2017jcyjBX0067, 2017-2020）主持 {C}5) 国家自然科学基金：Bbhog1调控昆虫病原真菌球孢白僵菌水分胁迫反应的分子基础 (31171902, 2012-2015) 主持 {C}6) {C}国家自然科学基金：影响球孢白僵菌穿透昆虫体壁的BbMPK1 MAPK下游基因研究(30871668, 2009-2011) 主持 {C}7) 国家高技术发展研究计划(863)：真菌、病毒类生物杀虫剂研究与产品创制(2011AA10A204-4, 2011-2015) 任务负责人 {C}8) 国家重点基础研究发展计划“973”课题：害虫生防真菌致病与抗逆的分子机理、遗传改良及应用(2009CB118904, 2009-2013) 任务负责人 {C}9) 教育部新世纪优秀人才支持计划：昆虫病原真菌球孢白僵菌虫菌体表面蛋白与逃避昆虫免疫的关系（NCET-11-0706, 2012-2014）主持 {C}10) 教育部高等学校博士学科点专项科研基金(博导类)：一个跨膜蛋白Bbtmp1与昆虫病原真菌球孢白僵菌氧化胁迫反应及侵染致病的关系(20120182110021, 2013-2015) 主持 {C}11) 重庆市首批高等学校优秀人才支持计划：利用MAPK信号途径研究球孢白僵菌抗逆相关基因 (20600206, 2009-2010) 主持 {C}12) 重庆市科委自然科学基金：Slt2 同源信号途径与杀虫真菌球孢白僵菌侵染致病的关系(CSTC2011BB1006, 2011-2014) 主持 {C}13) {C}国家高技术研究发展计划“863”项目：高效安全重组杀虫生物农药的研制与中试研究(2002AA245021, 2002-2005) 主持 {C}14) {C}国家自然科学基金：亲环蛋白BbCYCL-1在球孢白僵菌侵染致病过程中的作用(30471174, 2005-2007) 主持 {C}15) {C}国家自然科学基金：羧基转运蛋白BbJEN1与球孢白僵菌毒力的关系(30300235, 2004-2006) 主持 {C}16) {C}国家重点基础研究发展计划“973”课题：球孢白僵菌侵染与抗逆相关功能基因研究(2003CB114203, 2003-2008) 骨干研究人员

近期发表的代表性论文 {C}1) Wang H., He Z., Luo L., Zhao X., Lu Z., Luo T., Li M., Zhang Y.* An aldo-keto reductase, Bbakr1, is involved in stress response and detoxification of heavy metal chromium but not required for virulence in the insect fungal pathogen, Beauveria bassiana. Fungal Genet. Biol. 2018, 111: 7-15. {C}2) He Z., Zhao X., Lu Z., Wang H., Liu P., Zeng F., Zhang Y.* Comparative transcriptome and gene co-expression network analysis reveal genes and signaling pathways adaptively responsive to varied adverse stresses in the insect fungal pathogen, Beauveria bassiana. J. Invertebr. Pathol. 2018, 151: 169-181. 3) Luo Z., Ren H., Mousa J.J., Rangel D., Zhang Y., Bruner S.D., Keyhani N.O. The PacC transcription factor regulates secondary metabolite production, stress response, but has only minor effects on virulence in the insect pathogenic fungus Beauveria bassiana. Environ Microbiol. 2017, 19(2):788-802. 4) Yang Z., Jiang H., Zhao X., Lu Z., Luo Z., Li X., Zhao J., Zhang Y.* Correlation of cell surface proteins of distinct Beauveria bassiana cell types and adaption to varied environment and interaction with the host insect. Fungal Genet. Biol. 2017, 99:13-25. 5) He Z., Luo L., Keyhani N.O., Yu X., Ying S., Zhang Y.* The C-terminal MIR-containing region in the Pmt1 O-mannosyltransferase restrains sporulation and is dispensable for virulence in Beauveria bassiana. Appl. Microbiol. Biotechnol. 2017, 101(3):1143-1161. 6) Zhou Y., Keyhani N.O., Zhang Y., Luo Z., Fan Y., Li Y., Zhou Q., Chen J., Pei Y. Dissection of the contributions of cyclophilin genes to development and virulence in a fungal insect pathogen. Environ Microbiol. 2016, 18(11): 3812-3826. 7) Wang Y., Song X., Zhang Y., Wang B., Zou X. Effects of nitrogen availability on polymalic acid biosynthesis in the yeast-like fungus Aureobasidium pullulans. Microb. Cell Fact. 2016, 15:146 8) {C}Huang S., He Z., Zhang S., Keyhani N.O., Song Y., Yang Z., Jiang Y., Zhang W., Pei Y., Zhang Y.* Interplay between calcineurin and the Slt2 MAP-kinase in mediating cell wall integrity, conidiation and virulence in the insect fungal pathogen Beauveria bassiana. Fungal Genet. Biol. 2015, 83: 78-91. 9) {C}He Z., Zhang S., Keyhani N.O., Song Y., Huang S., Pei Y., Zhang Y.* A novel mitochondrial membrane protein, Ohmm, limits fungal oxidative stress resistance and virulence in the insect fungal pathogen Beauveria bassiana. Environ. Microbiol. 2015, 17 (11): 4213–4238. 10) Luo Z., Li Y., Mousa J., Bruner S., Zhang Y., Pei Y., Keyhani NO. Bbmsn2 acts as a pH-dependent negative regulator of secondary metabolite production in the entomopathogenic fungus Beauveria bassiana. Environ Microbiol. 2015, 17(4):1189-202. 11) Zhou Y., Hou L., Zhang Y., Fan Y., Luo Z., Jin D., Zhou Q., Li Y., Wang Y., Pei Y. Expression and promoter characterization of BbPacC, a pH response transcription factor gene of the entomopathogenic fungus Beauveria bassiana. Microbiol-SGM, 2014, 160, 353–361. 12) {C}Luo X., Keyhani N.O., Yu X., He Z., Luo Z., Pei Y., Zhang Y.* The MAP kinase Bbslt2 controls growth, conidiation, cell wall integrity, and virulence in the insect pathogenic fungus Beauveria bassiana. Fungal Genet. Biol. 2012, 49: 544–555. 13) {C}Zhang Y., Zhang J., Jiang X., Wang G., Luo Z., Fan Y., Wu Z., Pei Y. Requirement of a mitogen-activated protein kinase for appressorium formation and penetration of insect cuticle by the entomopathogenic fungus Beauveria bassiana. Appl.Environ. Microbiol. 2010, 76: 2262–2270. 14) {C}Zhang Y., Zhao J., Fang W., Zhang J., Luo Z., Zhang M., Fan Y., Pei Y. Mitogen-activated protein kinase hog1 in the entomopathogenic fungus Beauveria bassiana regulates environmental stress responses and virulence to insects. Appl. Environmen. Microbiol. 2009, 75: 3787–3795. 15) {C}Zhang Y., Li Z., Luo Z., Zhang J., Fan Y., Pei Y. Light stimulates conidiation of the entomopathogenic fungus Beauveria bassiana. Biocontrol Sci. Techn. 2009, 19: 91–101. 16) {C}Zhang Y., Feng M., Fan Y., Luo Z., Yang X., Wu D., Pei Y. A cuticle-degrading protease (CDEP-1) of Beauveria bassiana enhances virulence. Biocontrol Sci. Techn. 2008, 18: 557–569. 17) {C}Jin K., Zhang Y., Luo Z., Xiao Y., Fan Y., Wu D., Pei Y. An improved method for Beauveria bassiana transformation using phosphinothricin acetlytransferase and green fluorescent protein fusion gene as a selectable and visible marker. Biotechnol. Lett. 2008, 30: 1379–1383. (equal contribution to this work) 18) {C}Gao Q., Jin K., Ying S-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X., Xie X-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S., Zhong Y., Ma L-J., St. Leger RJ., Zhao G-P., Pei Y., Feng M-G., Xia Y., Wang C. Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum. PLoS Genetics 2011, 7: 1-18 (equal contribution authors) 19) {C}Zhou Y., Zhang Y., Luo Z., Fan Y., Tang G., Liu L., Pei Y. Selection of optimal reference genes for expression analysis in the entomopathogenic fungus Beauveria bassiana during development, under changing nutrient conditions, and after exposure to abiotic stresses. Appl. Microbiol.Biotechnol. 2012, 93(2):679-685. 20) {C}Jin K., Luo Z., Jiang X., Zhang Y., Zhou Y., Pei Y. Carbon catabolite repressor gene BbCre1 influences carbon source uptake but does not have a big impact on virulence in Beauveria bassiana. J. Invertebr. Pathol. 2011, 106: 400–406. 21) {C}Jin K., Zhang Y., Fang W., Luo Z., Zhou Y., Pei Y. Carboxylate transporter gene JEN1 from the entomopathogenic fungus Beauveria bassiana is involved in conidiation and virulence. Appl. Environ. Microbiol. 2010, 76: 254–263. 22) {C}Liao X., Zhang Y., Fan Y., Ma J., Zhou Y., Jin D., Pei Y. An ethanol inducible alc system for regulating gene expression in Beauveria bassiana. World J. Microb. Biot. 2009, 25: 2065–2069. 23) {C}Fan Y., Zhang Y., Yang X., Pei X., Guo S., Pei Y. Expression of a Beauveria bassiana chitinase (Bbchit1) in Escherichia coli and Pichia pastoris. Protein Expres. Purif. 2007, 56: 93–99. 24) {C}Fang W., Zhang Y., Yang X., Pei Y. Transformation of Beauveria bassiana mediated by Agrobacterium tumefaciens. J. Invertebr. Pathol. 2004, 85: 18–24. 25) {C}Fang W., Feng J., Fan Y., Zhang Y., Yang X., Bidochka MJ., St Leger RJ., Pei Y. Expressing a fusion protein with protease and chitinase activities increases the virulence of the insect pathogen Beauveria bassiana. J. Invertebr. Pathol. 2009, 102: 155–159. 26) {C}刘海，赵婧，李雪兵，刘鹏飞，罗廷英，张永军*. 腺苷酸核糖基化因子BbarfA 介导白僵菌孢子萌发和毒力. 微生物学报，2017，57（12）：1827–1838. 27) {C}林健文，罗志兵，骆星丹，张素红，裴 炎，张永军*. 莱势野村菌固体发酵培养基筛选与发酵条件优化. 植物保护学报, 2009, 36 (5): 437-442. 28) {C}李尊华，林健文，马金成，吴迪，张永军*. 变温干燥固体发酵产物对球孢白僵菌分生孢子性能的影响. 微生物学报 2008, 48 (7): 887-892. 29) {C}李涛，刘映红，李会云，张永军*. 球孢白僵菌对烟蚜茧蜂生命参数及控害效果的影响. 菌物学报 2007, 26 (3): 433-439. 30) {C}张永军，方卫国，肖月华，金凯，裴炎. 球孢白僵菌羧基转运蛋白BbJEN1基因及其上游序列的克隆与分析. 微生物学报 2004, 44 (2): 198-201.

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