教育背景
2009/06 ~ 2012/05, 美国亚利桑那大学,博士
2007/08 ~ 2009/05, 美国亚利桑那大学,硕士
2003/09 ~ 2007/06,中国西南大学,学士
工作经历
2017/09 ~ 至今,中国畜牧兽医学会动物生理生化分会,理事会理事
2017/03 ~ 至今,《Gene》杂志审稿人
2015/12 ~ 至今,重庆市生物化学与分子生物学会,理事会理事
2014/06 ~ 至今,重庆市科委,科技特派员
2013/01 ~ 至今,西南大学,动物科技学院,副教授,研究生导师
2012/10 ~ 2012/12,西南大学,动物科技学院,讲师
项目课题经历
主持
2016 ~ 2019,持续高浓度去甲肾上腺素对胎羊胰岛素分泌的影响和机制研究,国家自然科学基金(项目编号31602021)
2015 ~ 2017,长期高浓度去甲肾上腺素对绵羊胎儿胰岛素分泌调控的影响,重庆市科委前沿与创新(项目编号CSTC2014JCYJA80036)
2014 ~ 2016,中央高校基本科研业务费(项目编号XDJK2014C020)
2013 ~ 至今,西南大学博士基金(项目编号20710916)
参与
2013 ~ 2015,草食动物种质创新与健康养殖,重庆市科委(项目编号KJTD201334)
2016 ~ 2020,乳酸菌SL001对AD模型小鼠胆固醇代谢及Aβ生成的影响及作用机制研究,国家自然科学基金(项目编号31670123)
2016 ~ 2020,温和型热应激下胰岛素信号系统在公猪睾丸支持细胞乳酸生成中的分子机制,国家自然科学基金(项目编号31672624)
论文、成果、著作等
1. Camacho LE, Chen X, Hay WW Jr, Limesand SW. Enhanced insulin secretion and insulin sensitivity in young lambs with placental insufficiency-induced intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2017 Aug 1;313(2):R101-R109.
2. Chen X, Kelly AC, Yates DT, Macko AR, Lynch RM, Limesand SW. Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine. J Endocrinology. 2017 Feb;232(2):285-295. (影响因子 4.706)
3. Macko AR, Yates DT, Chen X, Shelton LA, Kelly AC, Davis MA, Camacho LE, Anderson MJ, Limesand SW. Adrenal Demedullation and Oxygen Supplementation Independently Increase Glucose-Stimulated Insulin Concentrations in Fetal Sheep With Intrauterine Growth Restriction. Endocrinology. 2016 May;157(5):2104-15.
4. Chen X (陈小川), Green AS, Macko AR, Yates DT, Kelly AC, Limesand SW*. Enhanced insulin secretion responsiveness and islet adrenergic desensitization after chronic norepinephrine suppression is discontinued in fetal sheep. Am J Physiol Endocrinol Metab. 2014 Jan 1;306(1):E58-64. doi: 10.1152/ajpendo.00517. (影响因子 4.142)
5. Macko AR, Yates DT, Chen X, Green AS, Kelly AC, Brown LD, Limesand SW*. Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced β-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation. J Dev Orig Health Dis. 2013 Oct 1;4(5).
6. Yates DT, Macko AR, Chen X, Green AS, Kelly AC, Anderson MJ, Fowden AL, Limesand SW*. Hypoxaemia-induced catecholamine secretion from adrenal chromaffin cells inhibits glucose-stimulated hyperinsulinaemia in fetal sheep. The Journal of Physiology. 2012: 590(Pt 21):5439-47.
7. Yates DT, Macko AR, Nearing M, Chen X, Rhoads RP, Limesand SW*. Developmental programming in response to intrauterine growth restriction impairs myoblast function and skeletal muscle metabolism. Journal of Pregnancy. 2012:631038.
8. Chen X, Rozance PJ, Hay WW Jr, Limesand SW*. Insulin-like Growth Factor and Fibroblast Growth Factor Expression Profiles in Growth Restricted Fetal Sheep Pancreas. Experimental Biology and Medicine. 2012: 237(5):524-9. (影响因子 2.688)
9. Green AS, Macko AR, Rozance PJ, Yates DT, Chen X (陈小川), Hay WW Jr, Limesand SW*. Characterization of glucose-insulin responsiveness and impact of fetal number and gender on insulin response in the sheep fetus. American Journal of Physiology Endocrinology and Metabolism. 2011: 300(5), E817-823.
10. Chen X, Fahy AL, Green AS, Anderson MJ, Rhoads Jr RP, Limesand SW*. β2-Adrenergic Receptor Desensitization in Perirenal Adipose Tissue in Fetuses and Lambs with Placental Insufficiency-induced Intrauterine Growth Restriction. The Journal of Physiology. 2010: 588(Pt 18):3539-49. (影响因子 4.739)
11. Leos RA, Anderson MJ, Chen X, Pugmire J, Anderson KA, Limesand SW*. Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction. American Journal of Physiology Endocrinology and Metabolism. 2010: 298, E770-778.
12. Zheng K, Chen X, Li Y. Molecular Cloning, Sequence Analysis, and Tissue Expression of Insulin-like Growth Factor-I from Chinese sucker Myxocyprinus asiaticus Bleeker, J, Chinese Journal of Zoology, 2007, 42(2): 39-45. [Chinese].
专利、著作版权等
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