1996年北京大学化学博士 ·1993年中国兰州大学化学硕士 1987年·兰州大学化学学士

2015年重庆西南大学药学院药理学教授- ·南卡罗来纳大学南卡罗来纳药学院研究助理教授，2011-2015 ·南阿拉巴马大学医学院研究讲师，2006-2011 ·德克萨斯大学休斯顿健康科学中心副研究员，德克萨斯州休斯顿，2004-2005 ·加拿大多伦多大学研究助理，2000-2004

The current research projects include but not limited to GPCRs, ion channels, PDEs in cardiac and vascular physiology: · Understand the mechanisms of signaling by GPCRs, particularly the bitter taste receptors, a sub family members of GPCRs. · Define the molecular mechanisms that stabilize and maintain sinoatrial node functions, the molecular mechanisms for cardiac muscle dysfunction in heart failure. · Characterize the structures and molecular mechanisms of the function of bitter taste receptors in the heart and cardiac vessels. · Identify the endogenous agonists of bitter taste receptors · Discover nature compounds from medicinal herbs as the bitter taste receptor agonists and research their potential implication in the treatment of cardiovascular diseases.

Selected Publications 1. Wang W., Duclot F., Groveman R.B., Carrier N., Qiao H.F., Fang X.Q., Wang H., Xin W.K., Jiang X.H., Salter W.M., Ding X.S., Kabbaj M., Yu X.M. 2018. Hippocampal protein kinase D1 is necessary for DHPG-induced learning and memory impairments in rats. PLoS One, 13 (4): e0195095 2. Xin W.K., Li N, Fernandes VS, and Petkov GV. 2016. Constitutively active PKA regulates neuronal acetylcholine release and contractility of guinea pig urinary bladder smooth muscle. Am J Physiol Renal Physiol, 310. F1377-84. 3. Xin W.K., Li N, Fernandes VS, Chen B, Rovner ES, and Petkov GV. 2016. BK channel regulation by phosphodiesterase type 1: A novel signaling pathway controlling human detrusor smooth muscle function. Am J Physiol Renal Physiol, 310. F994-9. 4. Xin W.K., Feinstein WP, Britain AL, Ochoa CD, Zhu B, Richter W, Leavesley SJ, Rich TC. 2015 Estimating the magnitude of near-membrane PDE4 activity in living cells. Am. J. Physiol. Cell Physiol. 309: C415, 2015. This article was selected by APSselect, Oct. 2015. “Each month, the most outstanding recently published papers from our ten research journals are selected and made available through this multi-journal website.” http://apsselect.physiology.org/ 5. Fernandes, V. S.#, Xin, W.K.#, and Petkov, G.V. 2015. Novel mechanism of hydrogen sulfide-induced guinea pig urinary bladder smooth muscle contraction: The role of BK channels and cholinergic neurotransmission. Am. J. Physiol. Cell Physiol. 309. C107-116. 6. Fang, X. Q., Qiao, H., Groveman, B. R., Feng, S., Pflueger, M., Xin, W. K., Ali, M. K., Lin, S. X., Xu, J., Duclot, F., Kabbaj, M., Wang, W., Ding, X. S., Santiago-Sim, T., Jiang, X. H., Salter, M. W. & Yu, X. M. 2015. Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors. Mol Brain 8:75. 7. Xin, W.K., Li, N., Cheng, Q.P., Fernandes, V. S., and Petkov, G.V. 2014. Constitutive PKA activity is essential for maintaining the excitability and contractility in guinea pig urinary bladder smooth muscle: Role of the BK channel. Am. J. Physiol. Cell Physiol. 307(12): C1142–C1150. 8. Xin, W.K., Li, N., Cheng, Q.P., and Petkov, G.V. 2014. BK channel-mediated relaxation of urinary bladder smooth muscle: A novel paradigm for phosphodiesterase type 4 regulation of bladder function. J. Pharmacol. Exp. Ther. 349(1):56-65. Figure 1 was selected as the Cover Caption of April 2014 issue. 9. Parajuli, S.P., Hristov, K.L., Sullivan, M.N., Xin, W.K., Smith, A.C., Earley, S., Malysz, J., and Petkov, G.V. 2013. Control of Urinary Bladder Smooth Muscle Excitability by the TRPM4 channel modulator 9-phenanthrol. Channels (Austin). 7(6): 537-540. 10. Smith, A.C., Hristov, K.L., Cheng, Q.P., Xin, W.K., Earley, S., Malysz, J., and Petkov, G.V. 2013. Novel role for the transient potential receptor melastatin 4 (TRPM4) channel in guinea pig detrusor smooth muscle excitation-contraction coupling. Am. J. Physiol. Cell Physiol. 304(5): C467-C477. 11. Smith, A.C., Parajuli, S.P., Hristov, K.L., Cheng, Q.P., Soder, R.P., Afeli, S.A.Y., Earley, S., Xin, W.K., Malysz, J., and Petkov, G.V. 2013. TRPM4 channel: A New Player in Urinary Bladder Smooth Muscle Function in Rats. Am. J. Physiol. Renal Physiol. 304(7): F918-F929. 12. Xin, W.K., Soder, R.P., Cheng, Q.P., Rovner, E.S., and Petkov, G.V. 2012. Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: role for ryanodine receptor mediated BK channel activation. Am. J. Physiol. Cell Physiol. 303(10): C1079-C1089. 13. Xin, W.K., Cheng, Q.P., Soder, R.P., Rovner, E.S., and Petkov, G.V. 2012. Constitutively active phosphodiesterase activity regulates urinary bladder smooth muscle function: Critical role of KCa1.1 channel. Am. J. Physiol. Renal Physiol. 303(9): F1300-F1306. 14. Horvat S.J., Deshpande D.A., Yan H, Panettieri R.A., Codina J, Dubose T.D., Jr., Xin W.K., Rich T.C., and Penn R.B. 2012. A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle. FASEB J. 26(9):3670-3679. 15. Xin, W.K., Cheng, Q.P., Soder, R.P., and Petkov, G.V. 2012. Inhibition of phosphodiesterases relaxes detrusor smooth muscle via activation of the large conductance voltage- and Ca2+-activated K+ channel. Am. J. Physiol. Cell Physiol. 302(9):C1361-C1370. 16. Xin W.K., Yang X., Rich T.C., Krieg T., Barrington R., Cohen M.V., and Downey J.M. 2012. All Preconditioning-Related G Protein-Coupled Receptors Can be Demonstrated in the Rabbit Cardiomyocyte. J Cardiovasc. Pharmacol. Ther. 17:190-198. 17. Yang X., Xin W.K., Yang X.M., Kuno A., Rich T.C., Cohen M.V., and Downey J.M. 2011. A2B adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin. Br J Pharmacol 163:995-1006. 18. Xin, W.K., Tran, T.M., Richter, W., Clark, R.B., and Rich, T.C. 2008. Roles of GRK and PDE4 activities in the regulation of β2-adrenergic signaling. J. Gen. Physiol. 131(4):349-364. 19. Rich, T.C., Xin, W.K., Mehats, C., Hassell, K.A., Piggott, L.A., Le, X., Karpen, J.W., and Conti, M. 2007. Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells. Am. J. Physiol. Cell Physiol. 292:319-331. 20. Xin, W.K., Zhao, X.H., Xu, J., Lei, G., Kwan, C.L., Zhu, K.M., Cho, J.S., Duff, M., Ellen, R.P., McCulloch, C.A., and Yu, X.M. 2005. The removal of extracellular calcium: a novel mechanism underlying the recruitment of N-methyl-D-aspartate (NMDA) receptors in neurotoxicity. Eur. J. Neurosci. 21:622-636. 21. Xin, W.K., Kwan, C.L., Zhao, X.H., Xu, J., Ellen, R.P., McCulloch, C.A., and Yu. X.M. 2005. A functional interaction of sodium and calcium in the regulation of NMDA receptor activity by remote NMDA receptors. J. Neurosci. 25:139-148. 22. Xin, W.K., Shen, X.M., Li, H., and Dryhurst, G. 2000. Oxidative metabolites of 5-S-cysteinylnorepinephrine are irreversible inhibitors of mitochondrial complex I and the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complex: possible implications for neurodegenerative brain disorders. Chem. Res. Toxicol. 13:749-760. 23. Zhuang, Q.K., Dai, H.C., Gao, X.X., and Xin, W.K. 2000. Electrochemical studies of the effect of lanthanide ions on the activity of glutamate dehydrogenase. Bioelectrochem. 52:37-41. 24. Xin, W.K., Gao, X.X. 1996. The study of the effect of lanthanide ions on the kinetics of glutamate dehydrogenase by chronoamperometric method. Analyst 121:687-690. 25. Xin, W.K., Gao, X.X. 1996. A chronoamperometry method for study on effect of lanthanide ions on glutamate dehydrogenase. Chin. Sci. Bull., 4(12). 26. Xin, W.K., Jiang, Z.W., Gao, X.X. 1995. The function of rare earth ions on "ion-gate" of the glutathione monolayer gold electrode. Chin. Chem. Lett., 6(6), 513-516.

Rich, T.C., Xin, W.K., Leavesley, S.J., and Taylor, M. 2015. Chapter 6: Channel based reporters for cAMP detection. In: cAMP Signaling. M. Zaccolo Ed.. Springer Science+ Business Media New York. •ISBN 978-1-4939-2537-7