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邹懿

领域:生物产业 学校:西南大学职称:教授

真菌天然药物合成生物学与生物酶工程、农作物病原真菌天然产物酶学与化学生态学...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

2009. 09 - 2013.12 上海交通大学,微生物代谢国家重点实验室,生物学,博士 2006. 09 - 2009.07 西南大学药学院,微生物与生化药学,硕士 2002. 09 - 2006. 07 西南大学药学院,制药工程,学士

工作经历

2017. 07 - 至今 西南大学药学院,教授 2014. 01 - 2017.01 美国加州大学洛杉矶分校,博士后

项目课题经历

目前承担的课题 1. 2019国家自然基金委面上项目(NSFC31870022,主持) 2. 2018重庆市留学生创新创业计划重点项目(cx2018006,主持) 3. 2018中组部海外高层次人才青年项目(A类资助) 4. 2018中央高校业务费重点项目(XDJK2018B035,主持) 5. 2017西南大学“聚贤工程”人才启动基金(SWU117034,主持)

论文、成果、著作等

论文发表 @ SWU 独立成立课题组以来(2017. 07 -) 1. Zhang, J-M., Wang, H-H., Liu, X., Hu, C-H., Zou. Y.* Heterologous- and Engineered- Biosynthesis of Nematocidal Polyketide-Nonribosomal Peptide Hybrid Macrolactone from Extreme Thermophilic Fungi. J. Am. Chem. Soc. 2020, doi.org/10.1021/jacs.9b11410. 2. Zeng, H-C., Yin, G-P., Wei, Q., Li, D-H., Wang, Y., Hu, Y-C., Hu, C-H.*, Zou. Y.* Unprecedented [5.5.5.6]Dioxafenestrane Ring Construction in Fungal Insecticidal Sesquiterpene Biosynthesis. Angew. Chem. Int. Ed. 2019, 58, 6569-6573. (Hot off the Press, Nat. Prod. Rep., 2019, 36, 1039-1043) 3. Feng, C., Wei, Q., Hu, C-H.*, Zou. Y.* Biosynthesis of Diphenyl Ethers in Fungi. Org. Lett. 2019, 21, 3114-3118. 4. Chen, X-W., Wang, L., Zhang, J-M., Jiang, T., Hu, C-H., Li, D-H.*, Zou. Y.* Immunosuppressant Mycophenolic Acid Biosynthesis Employs a New Globin-like Enzyme for Prenyl Side Chain Cleavage. Acta. Pharm. Sin. B. 2019, 9, 1253-1258. 5. Yan, D-J., Chen, Q-B., Gao, J., Bai, J., Liu, B-Y., Zhang, Y-L., Zhang, L., Zhang, C., Zou, Y., Hu, Y-C.* Complexity and Diversity Generation in the Biosynthesis of Fumiquinazoline-Related Peptidyl Alkaloids. Org. Lett. 2019, 21, 1475-1479. 6. Bai, J., Yan, D., Zhang, T., Guo, Y, Liu, Y., Zou, Y., Tang, M-C., Liu, B., Wu, Q., Yu, S.*, Tang, Y.*, Hu, Y.* A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angew. Chem. Intl. Ed. 2017, 56, 4782-4786. @ UCLA 博士后期间(2014. 01 - 2017. 01) 7. Tang, M-C.#, Zou, Y.#, Yee, D., Tang, Y.* Identification of the Pyranonigrin A Biosynthetic Gene Cluster by Genome Mining in Penicillium thymicola IBT 5891. AIChE Journal. 2018, 64, 4182-4186. (#co-first author) 8. Zou, Y., Garcia-Borràs, M., Tang, M-C., Hirayama, Y., Li, D., Li, L., Watanabe, K., Houk, K. N.*, Tang, Y.* Enzyme-Catalyzed Cationic Epoxide Rearrangements in Quinolone Alkaloid Biosynthesis. Nat. Chem. Biol. 2017, 13, 325-332. (Recommended as the exceptional paper by F1000 Prime) 9. Tang, M-C.#, Zou, Y.#, Watanabe, K., Walsh, C. T.*, Tang, Y.* Oxidative Cyclization in Natural Product Biosynthesis. Chem. Rev. 2017, 117, 5226-5333. (#co-first author) 10. Zou, Y., Zhan, Z., Li, D., Tang, M-C., Cacho, R., Watanabe, K., Tang, Y.* Tandem Prenyltransferases Catalyze Isoprenoid Elongation and Complexity Generation in Biosynthesis of Quinolone Alkaloids. J. Am. Chem. Soc. 2015, 137, 4980-4983. (Hot off the Press, Nat. Prod. Rep. 2015, 32, 1165-1169) 11. Zou, Y.#, Xu, W.#, Tsunematsu, Y., Tang, M-C., Watanabe, K., Tang, Y.* Methylation-dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis. Org. Lett. 2014, 16, 6390-6393. (#co-first author) 12. Tang, M-C., Lin, H-C., Li, D., Zou, Y., Li, J., Xu, W., Cacho, R. A., Hillenmeyer, M., Garg, N. K., Tang, Y.* Discovery of Unclustered Fungal Indole Diterpene Biosynthetic Pathways through Combinatorial Pathway Reassembly in Engineered Yeast. J. Am. Chem. Soc. 2015, 137, 13724-13727. 13. Yu, X., Liu, F., Zou, Y., Tang, M-C., Hang, L., Houk, K. N.*, Tang, Y.* Biosynthesis of Strained Piperazine Alkaloids- Uncovering the Concise Pathway of Herquline A. J. Am. Chem. Soc. 2016, 138, 13529-13532. 14. Li L., Yu, P., Tang, M-C., Zou, Y., Gao S-S., Hung, Y-S., Zhao, M-X., Watanabe, K., Houk, K. N.*, Tang, Y.* Biochemical Characterization of a Eukaryotic Decalin-Forming Diels-Alderase. J. Am. Chem. Soc. 2016, 138, 15837-15840.
 15. Liu, N., Hung, Y., Gao, S-S., Hang, L., Zou, Y., Chooi, Y-H.*, Tang, Y.* Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway. Org. Lett. 2017, 19, 3560-3563.
 @ SJTU 博士期间(2009. 09 - 2013. 07) 16. Zou, Y., Fang, Q., Yin, H., Liang, Z., Kong, D., Bai, L., Deng, Z., Lin, S.* Stereospecific Biosynthesis of β-Methyltryptophan from l-Tryptophan Features a Stereochemical Switch. Angew. Chem. Int. Ed. 2013, 52, 12951-12955. 17. Zou, Y., Yin, H., Kong, D., Deng, Z., Lin, S.* A Trans-acting Ketoreductase in Biosynthesis of a Symmetric Polyketide Dimer SIA7248. ChemBioChem 2013, 14, 679-683. 18. Huang, T., Duan, Y., Zou, Y., Deng, Z., Lin, S.* NRPS Protein MarQ Catalyzes Flexible Adenylation and Specific S-Methylation. ACS Chem. Biol. 2018, 13, 2387-2391. 19. Zhang,Y., Zou, Y., Brock, N. L., Huang, T., Lan, Y., Wang, X., Deng, Z., Tang, Y., Lin, S.* Characterization of 2-Oxindole Forming Heme Enzyme MarE, Expanding the Functional Diversity of the Tryptophan Dioxygenase Superfamily. J. Am. Chem. Soc., 2017, 139, 11887-11894. 20. Han, M.#, Yin, H.#, Zou, Y., Brock, N. L., Huang, T., Deng, Z., Chu, Y.*, Lin, S.* An Acyl Transfer Reaction Catalyzed by an Epimerase MarH. ACS Catalysis. 2016, 6, 788-792.
 21. Lan, Y., Zou, Y., Huang, T., Wang, X., Brock, N. L., Deng, Z., Lin, S.* Indole Methylation Protects Diketopiperazine Configuration in the Maremycin Biosynthetic Pathway. Sci. China. Chem. 2016, 59, 1224-1228. 22. Kong, D., Zou, Y., Zhang, Z., Xu, F., Brock, N. L., Zhang, L., Deng, Z., Lin, S.* Identification of (2S,3S)-β-Methyltryptophan as the Real Biosynthetic Intermediate of Antitumor Agent Streptonigrin. Sci. Rep. 2016, 6, 20273. 23. Wang, H., Zhang, H., Zou, Y., Mi, Y., Lin, S., Xie, Z., Yan, Y., Zhang, H.* Structural Insight into the Tetramerization of an Iterative Ketoreductase SiaM through Aromatic Residues in the Interfaces. PloS ONE. 2014, 9, e97996.
 @ SWU 硕士期间(2006. 09 - 2009. 07) 24. Hu, C-H.*, Zou, Y., Zhao, W. Effect of Soybean Oil on the Production of Mycelial Biomass and Pleuromutilin in the Shake-flask Culture of Pleurotus mutilis. World. J. Microb. Biot. 2009, 25, 1705-1711. 25. Hu, C-H.*, Zou, Y. Mutilins Derivatives-from Veterinary to Human-used Antibiotics. Mini-Rev. Med. Chem. 2009, 9, 1397-1406.

专利、著作版权等

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