首页 > 专家库
胡昌华

领域:生物产业 学校:西南大学职称:教授

微生物来源药物生物合成、中药微生物组、药源性尤其是抗精神药物代谢性副反应机制的研究...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

1992年-1995年在西南师范大学攻读硕士学位;1998年-2001年在华西医科大学攻读博士学位

工作经历

项目课题经历

先后承担多项国家和重庆市科研项目等研究工作

论文、成果、著作等

6.Li Yanjie , Zhao Xiaomin , Feng Xiyu , Liu Xuemei, Deng Chao, Hu Chang-Hua . Berberine Alleviates Olanzapine-induced adipogenesis via the AMPK_–SREBP pathway in 3T3-L1 cells.Int J Mol Sci ,2016, 17, 1865; doi:10.3390/ijms17111865 7. Liu Xuemei, Deng Chao , Cao Shuang, Gong Jingwen , Wang Bo-Chu, Hu Chang-Hua . Acute effects of oral olanzapine treatment on the expression of fatty acid and cholesterol metabolism-related gene in rats. Life Sciences.2015, 128 :72–78 8. Liu Xuemei, Lian Jiamei , Hu Chang-Hua , Deng Chao , Betahistine co-treatment ameliorates dyslipidemia induced bychronic olanzapine treatment in rats through modulation of hepatic AMPKα-SREBP-1 and PPARα -dependent pathways. Pharmacological Research.2015, 100: 36–46. 9. Deng Chao, Pan Bo, Hu Chang-Hua, Han Mei, Huang Xu-Feng. Differential effects of short-and long-term antipsychotic treatment on the expression of neuregulin-1 and ErbB4 receptors in the rat brain. Psychiatry Research. 2015:225:347–354. 10. Li Yanjie, Fu Jieqin, Yuan Xue, Hu Chang-hua Simvastatin inhibits the proliferation of A549 lung cancer cells through oxidative stress and up-regulation of SOD2. Pharmazie,2014, 69:610-614. 11. Liu Li , Hu Chang-Hua , Liu Gang et al.The thioredoxin reductase-encoding gene ActrxR1 is involved in the cephalosporin C production of Acremonium chrysogenum in methionine-supplemented medium. Applied Microbiology and Biotechnology. 2013, 97(6):2551–2562. 12.Li Linli, Ma Tingme, Liu Qing ,Huang Yuq, Hu Changhua ,Liao Guojian .Improvement of daptomycin production in streptomyces roseosporus through the Acquisition of Pleuromutilin resistance. BioMed Research International.2013, http://dx.doi.org/10.1155/2013/479742 13. Wang Lei, Hu Changhua , Guojian Liao. Improvement of A21978C production in Streptomyces roseosporus by reporter-guided rpsL mutation selection. Journal of Applied Microbiology, 2012. 112(6):1095-101. 14. Zou Xiang, Li Bing, Hu Changhua. Fed-batch fermentation for pleuromutilin production by Pleurotus mutilis. Research Journal of Biotechnology. 2012,7(1): 67-72. 15. Xiang Lixin, Zhou Ruimei, Fu Ailing, Xu Xingran, Huang Yuqi, Hu Changhua. Targeted delivery of large fusion protein into hippocampal neurons through systemic administration. Journal of Drug Targeting. 2011, 19(8):632-6. 16. Hu Changhua, Deng Chao, Mackovski Nikolce, et al. Effects of simvastatin and 6-hydroxydopamine on histaminergic H1 receptor binding density in rat brains. Progress in Neuro- Psychopharmacology & Biological Psychiatry. 2010, 34(8):1419-1425. 17. Hu Changhua, Pai Nigash, Huang Xunfeng, Deng Chao. Potential control of risperidone-induced cognitive deficits by adjunctive aripiprazole treatment. Journal of Clinical Psychopharmacology.2011, 31(1):135-136. 18. Xing Wei, Deng Chao, Hu Changhua. Molecular cloning and characterization of the global regulator LaeA in Penicillium citrinum. Biotechnology Letters, 2010, 32(11):1733-1737 19. Deng Chao, Chen jiezhong, Hu Changhua. What is the mechanism for aripiprazole’s effect on reducing olanzapine-induced obesity? Journal of Clinical Psychopharmacology.2010, 30(4).480 . 20.张虎,曹双,胡昌华.丝状真菌中的Velvet家族蛋白.微生物学报,2017,57(12): 1751-1760. 21.廖国建,沈兰,胡昌华. 拟核结合蛋白调控链霉菌形态分化和次级代谢的作用和机制,微生物学报,2017,57(5):651-658 22.朱海游,胡昌华.基于表皮生长因子受体的靶向治疗药物研发进展.中国新药杂志,2015,24(20):2376-2382. 23. 郑跃亮,曹双,黄宇琪,廖国建,胡昌华.过表达全局调控因子LaeA 对橘青霉美伐他汀的合成及产孢的影响。微生物学报,2014,54(12) :1438 - 1445. 24.邵 倩,胡昌华。治疗乳腺癌的抗体药物研究进展. 中国新药杂志,2014,23(23):2734-2738. 25.廖国建,赵燕莉,徐康力,李丹,代禄丹,胡昌华.环境放线菌中的达托霉素抗性机制。微生物学报.2013,53(2):210-216 26.郎廷元,晏菊芳,胡昌华.基于报告基因技术的肿瘤多药耐药高通量筛选模型.中国科学化学 2011,41(10):1559 – 1564 27.海乐,黄宇琪,廖国建,胡昌华.放线菌Streptomyces sp. FJ3的核糖体工程改良与活性产物的分离微生物学报,2011,51(7) :934- 940. 28.周锐,廖国建,胡昌华.丝状真菌次级代谢产物生物合成的表观遗传调控. 生物工程学报.2011, 27(8): 1142−1148. 29.冯慧云,邢伟,胡昌华.丝状真菌新型全局性调控因子LaeA. 微生物学报.2011,51( 9) : 1141 -1145. 30.李冰,胡昌华.2009年美国FDA批准的生物药物及其解析.中国药学杂志,2010,45(23):59-63 31.王磊,胡昌华.他汀类药物抗肿瘤作用新机制.中国药学杂志,2010,45(22):79-82 32.刘莉,胡昌华.真菌二萜环化酶研究进展.微生物学报,2010,50(11):1438-1445 33.付婕琴,刘海洋,胡昌华.他汀药物在阿尔茨海默病治疗中的非降脂新机制。中国药学杂志,2010.45(11):804-807

专利、著作版权等

1.主编《药学概论》(科学出版社,2016年8月);主编《药物制备综合实验教程》(科学出版社,2015年10月); 2.副主编《生物制药学》(科学出版社,2017年8月);副主编《药学导论》(科学出版社,2017年6月);副主编《药学分子生物学》(中国医药出版社,2017年8月);参编全国药学规划教材《生物技术制药概论》(中国医药出版社,2015年1月)。 3.专利重组人甲状旁腺激素的制备方法 ZL 02153384.9已授权;专利截短侧耳素的溶剂提取工艺, ZL20101018018.2已授权。,授ࣺᯬ
声明:本站专家信息来源于各高校官网。