教育背景
1980~1987年于哈尔滨工业大学,获得工学学士和硕士学位;1987~1990年于北京大学,获得理学博士学位;1990~1992年于中国科学院生物物理所从事分子酶学专业博士后研究工作
工作经历
1992~1993年, 于中国科学院生物物理所分子酶学实验室工作;1993~至今,在西南大学工作,1995年破格晋升研究员,1999年成为“农产品储藏与加工”专业博士生导师;2005年至今,在西南大学药学院工作;2012年,国家中医药总局“中药化学”重点学科负责人、重庆市百名高端工程技术人才;2017年成为“黄连研究开发”首席专家
项目课题经历
主持的部分研究课题
1)、2017.12-2021.12年,黄连大品种开发(2017YFC1702600),中医药现代化研究重点专项,主持人:李学刚,科技部,1783万元。
2)、2017.1-2018.6年,重庆市现代特色效益农业产业中药材技术体系创新团队 “中药材综合开发利用”岗位专家(2017[5],重庆市农委《中药材产业技术体系》),主持人:李学刚,20万元。
3)、2017.1-2020.12年,参加科技部专项“中兽医药现代化与绿色养殖技术研究”课题“中兽药成方原则及活性物质筛查研究”研究,主持子课题“防治畜禽呼吸、消化系统疾病的现代中兽药产品创制”子课题(2017YFD0501504),主持人:李学刚,经费58.9万元。
4)、2017.4-2019.12年,甘薯产业化开发与扶贫示范(cstc2017shms-kjfp80004),主持人:李学刚,重庆市科委,20万元。
5)、2016.10-2019.10年,参与重庆市科委重点产业专项“道地中药材种植及综合开发关键技术研究与示范”的课题“道地中药材种植及综合开发关键技术研究与应用”(cstc2016zdcy-ztzx1001)研究,主持子课题“黄连副产物综合开发关键技术研究与应用”,主持人:李学刚,30万元。
6)、2014.1-2016.12年,烷基小檗碱调节体内胆固醇代谢分子机制,教育部博士点基金,主持人 李学刚,20130182110023。项目经费12万元。
7)、2014.1-2016.12年,黄连产地加工新技术,重庆市教委重点项目,主持人 李学刚,KJZH14203。项目经费30万元。
8)、2013~2016年,重庆百名高端工程技术人才培养计划,重庆市科委。30万元。主持人:李学刚。
9)、2013~2023年,关于联合申报味连须药材和味连须散新兽药,北京中农劲腾生物技术有限公司、成都乾坤动物药业有限公司、郑州后羿制药有限公司。75万元。主持人:李学刚。
10)、2011~2014年,“石柱黄连规范化种植基地及其SOP优化升级研究”,科技部十二五科技支撑计划项目,主持人 李学刚,2011BAI13B02-1。项目经费540万元。
11)、2010~2012年,“治疗糖尿病并发症中药新药研究”,科技部重大新药创制,主持人 叶小利、李学刚,2010ZX09401-306-3-10。57.5万元。
12)、2008~2011年,主持重庆市科委重大专项“黄连综合开发利用”(项目编号:CSTC,2008AA5021)。项目总金费120万元。
13)、2007~2009年,主持国家自然科学基金项目“鱼腥草素同系物与细菌细胞膜相互作用”(项目编号:20673084)。
14)、1995.1~1997.12年, 主持国家自然科学基金项目“表面活性剂与肌酸激酶和超氧化物歧化酶相互作用” (主持;批号:29473117)的研究工作。
15)、2008-2011年,主研重庆市卫生局重点项目“黄连血脂灵”新药研发(项目编号:渝中医(2008)1-2号)。项目总金费10万元。
16)、2012-2014年,平抑舒”治疗糖尿病肾病的临床疗效观察,重庆市卫生局重点项目。10万元。
17)、2005-2007年,主持 “黄连副产物开发利用关键技术研究”(石柱县科委,研究经费25万元)。
论文、成果、著作等
论文
1. 1.Yubo Xiao, Cheng Tian, Tao Huang, Bing Han, Meimei Wang, Hang Ma, Zhaoxing Li,Xiaoli Ye, Xuegang Li 。8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo。Life Sciences. 192(2018):259-269.
2. Bing Han,Shuming Kou,Kai He,Yulong Han,Yue Wang,Tao Huang,Xia Zhou,Yubo Xiao,Xuegang Li,Xiaoli Ye. Anti-hypercholesterolemic Effect of Berbamine Isolated from RhizomaCoptidis in Hypercholesterolemic Zebrafish Induced by High-Cholesterol Diet. Iranian Journal of Pharmaceutical Research, 2018,17 (1):292-306.
3. Fang-Ni Chai a , Jiang Zhang a , Hong-Mei Xiang a , He-Shan Xu a , Yuan-Feng Li a , Wen-Yu Ma a ,Xue-Gang Li b , Xiao-Li Ye a,. Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122. Biomedicine & Pharmacotherapy, Volume 98, February 2018, Pages 180–190.
4. Fang-Ni Chai, Wen-Yu Ma, Jian Zhang, He-Shan Xu, Yuan-Feng Li, Qi-De Zhou, Xue-Gang Lib, Xiao-Li Yea. Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122. Biomedicine & Pharmacotherapy. 103 (2018) :1002–1011.
5. Xiao Yubo, Feng Min, Ran Haiying, et al. (1899). Identification of key differentially expressed genes associated with non‑small cell lung cancer by bioinformatics analyses. Molecular Medicine Reports, 2018, 17:6379-6386.
6. Han, Bing; Jiang, Pu ; Liu, Wuyang ; Xu, Heshan ; Li , Yuanfeng ; Li , Zhaoxing ; Ma, Hang ; Yu, Yang ; Li, Xuegang; Ye, Xiaoli。 Role of daucosterol linoleate on breast cancer: studies on apoptosis and metastasis。Journal of Agricultural and Food Chemistry。66(2018):6031-6041.
7. Yuli Hu, Shoujun Fan, Xiaobing Liao, Chao Chen, Liang Su, Xuegang Li*. Pharmacokinetics, excretion of 8-cetylberberine and its main metabolites in rat urine. Journal of Pharmaceutical and Biomedical Analysis 132 (2017) 195–206。
8. Min Feng,Zongyao Zou,Xia Zhou,Yinran Hu, Hang Ma,Yubo Xiao,Xuegang Li,Xiaoli Ye. Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE−/−mice。International Immunopharmacology, 43 (2017):195–202。
9. Yin-Ran Hu, Hang Ma, Zong-Yao Zou, Kai He, Yu-Bo Xiao, Yue Wang, Min Feng, Xiao-Li Ye, Xue-Gang Li.* Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress。Biomedicine & Pharmacotherapy。85(2017):313–3。
10. Tao Huang, Yubo Xiao, Lin Yi, Ling Li, Meimei Wang, Cheng Tian, Hang Ma, Kai He, Yue Wang, Bing Han, Xiaoli Ye*, and Xuegang Li*. Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo. Scientific Reports, 2017, 7:38524 | DOI: 10.1038/
11. Kai He,Hang Ma,Heshan Xu,Zongyao Zou,Min Feng,Xuegang Li,Xiaoli Ye。Anti-hyperlipidemic effects of Rhizoma Coptidis alkaloids are achieved through modulation of the enterohepatic circulation of bile acids and cross-talk between the gut microbiota and the liver. Journal of Functional Foods. 35,(2017),205-215.
12. Meimei Wang1,2, Hang Ma1,2, Cheng Tian1,2, Shanshan Liu1 , Xiaoli Ye2, Deqi Zhou3,Yanlin Li4, Nie Hui3*,Xuegang Li1,2*。Bioassay-guided isolation of glycoprotein SPG-56 from sweet potato Zhongshu-1 and its anti-colon cancer activity in vitro and in vivo。Journal of Functional Foods. 35,(2017),315-324.
13. Min Feng, Shu-Zhen Kong , Zhen-Xu Wang , Kai He, Zong-Yao Zou, Yin-Ran Hu, Hang Ma, Xue-Gang Li, Xiao-Li Ye。 The protective effect of coptisine on experimental atherosclerosis ApoE-/- mice is mediated by MAPK/NF-kB-dependent pathway。Biomedicine & Pharmacotherapy 93 (2017) 721–729。
14. Kai He a,b, Yinran Hua, HangMa a, Zongyao Zou a, Yubo Xiaoa, Yong Yangb, Min Feng a,Xuegang Li a,, Xiaoli Ye c。Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways。Biochimica et Biophysica Acta。 1862: 1696–1709 ,2016。
15. Kai He, Shanghua Song, Zongyao Zou, Min Feng, Dezhen Wang, Yanzhi Wang, Xuegang Li* and Xiaoli Ye*. The Hypoglycemic and Synergistic Effect of Loganin, Morroniside, and Ursolic Acid Isolated from the Fruits of Cornus officinalis. Phytotherapy Reserch (Phytother. Res.)。30: 283–291 (2016)。
16. Kai He, Shuming Kou, Zongyao Zou, Yinran Hu, Min Feng, Bin Han, Xuegang Li*, Xiaoli Ye*. Hypolipidemic Effects of Alkaloids from Rhizoma Coptidis in Diet-Induced Hyperlipidemic Hamsters. Planta Medica, 2016, 82:1-9 (IF 2.152)
17. Shuming Kou, Bing Han, Yue Wang, Tao Huang, Kai He, Yulong Han, Xia Zhou, Xiaoli Ye*, Xuegang Li*. Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters. Life Science, 2016,151:50-60 (IF 2.702)
18. Zong-YaoZou,Yin-RanHu,HangMa,MinFeng,Xue-GangLi,Xiao-LiYe。Epiberberine reduces serum cholesterol indiet-induced dyslipidemia Syrian golden hamsters via network pathways involving cholesterol metabolism。European Journal of Pharmacology。774:1-9,2016。
19. Xia Zhou, Yaozong Peng, Ling Li, Kai He, Tao Huang, Shaoxia Mou, Min Feng, Bing Han, Xiaoli Ye, Xuegang Li. Effects of dietary supplementations with the fibrous root of Rhizoma Coptidis and its main alkaloids on non-specific immunity and disease resistance of common carp. Veterinal Immnology and Immunopathology. 173:34-38, 2016.
20. Ling Li, Tao Huang, Cheng Tian, Yubo Xiao, Shuming Kou, Xia Zhou, Shanshan Liu,Xiaoli Ye, Xuegang Li。The defensive effect of phellodendrine against AAPH-induced oxidativestress through regulating the AKT/NF-κB pathway in zebrafish embryos。Life Sciences,157:97-106,2016。
21. Hang Ma,Yinran Hu, Zongyao Zou,Min Feng,Xiaoli Ye and Xuegang Li1*。Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK-Ay Mice。DRUG DEVELOPMENT RESEARCH, 77 : 163–170 (2016)。
22. Yue Wang, Yulong Han, Fangni Chai, Hongmei Xiang, Tao Huang,Shuming Kou , Bing Han, Xiaobao Gong, Xiaoli Ye*, Xuegang Li*. The antihypercholesterolemic effect of columbamine from Rhizoma Coptidis in HFHC-diet induced hamsters through HNF-4α/FTF-mediated CYP7A1 activation. Fitoterapia, 2016,115:111-121.
23. Kai He, Zongyao Zou, Yinran Hu ,et al. Purification of α-glucosidase from mouse intestine by countercurrent chromatography coupled with a reverse micelle solvent system. Journal of separation science. 2016, 39,703–708.
24. Na Ning, Kai He, Hao Wu, Yanzhi Wang, Zongyao Zou, Xuegang Li*, Xiaoli Ye. Hypolipidemic Effect and Mechanism of Palmatine from Coptis chinensis in Hamsters Fed High-Fat Diet, Phytotherapy Research, 2015, 29:668-673,
25. Kai He, Xiaoli Ye, Hao Wu, YanZhi Wang, Zongyao Zou, Na Ning, Yinran Hu, Biao Chen, Xuedong Fang, Xuegang Li*. The safety and antihypercholesterolemic effect of Coptisine in Syrian golden hamsters. Lipids, 50(2): 185-194 (2015).
26. Na Ning, Yanzhi Wang, Zongyao Zou, Dezhou Zhang, Dezhen Wang, Xuegang Li*. Pharmacological and safety evaluation of fibrous root of Rhizoma Coptidis. Environmentan Toxicology and Pharmacology, 2015, 39(1): 53-69,
27. Zong-Yao Zou, Yin-Ran Hu, Hang Ma, Yan-Zhi Wang, Kai He, Shuang Xia, Hao Wu, Dong-Fang Xue, Xue-Gang Li*, Xiao-Li Ye*. Coptisine attenuates obesity-related inflammation through LPS/TLR-4-mediated signaling pathway in Syrian golden hamsters. Fitoterapia, 2015, 105(9): 139–146.
28. Yong Yang, Zaiqi Zhang, Shuping Li, Xiaoli Ye, Xuegang Li, Kai He. Synergy effects of herb extracts: Pharmacokinetics and pharmacodynamic basis. Fitoterapia. 92 (2014):133–147.
29. Hao Wua, Kai He, YanZhi Wang, DongFang Xue, Na Ning, Zongyao Zou, Xiaoli Ye∗, Xuegang Li∗, DeZhen Wang, Jie Pang。The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis。 Phytomedicine。 21 (2014):1373–1381
30. Yangping Ding,Xiaoli Ye,Jiaying Zhu,Xiaokang Zhu,Xuegang Li*,Bingcan Chen。Structural modification of berberine alkaloid and their hypoglycemic activity。JOURNAL OF FUNCTIONAL FOODS。7(2014):229–237。
31. Jun Yi, Xiaoli Ye, Dezhen Wang, Kai He, Yong Yang, Xujing Liu, Xuegang Li. Safety evaluation of main alkaloids from Rhizoma Coptidis. Journal of Ethnopharmacology, 2013.145:303-310。
32. Jinfeng Wu, Xiaoli Ye, Xuelong Cui, Xuegang Li, Lifeng Zheng and Zhu Chen. Reducing the inhibitory effect of cigarette smoke on oral peroxidase activity by addition of berberine in cigarette filter. Toxicology and Industrial Health. 2013. 29(4):317.
33. Kai He, Xiaoli Ye∗, Xuegang Li∗∗, Hongying Chen, Lujiang Yuan, Yafei Deng, Xin Chen, Xiaoduo Li。Separation of two constituents from purple sweet potato by combination of silica gel column and high-speed counter-current chromatography。Journal of Chromatography B。2012,881-882:49~54.
34. Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells.Hong-Ying Chen, Xiao-Li Ye, Xue-Long Cui, Kai He, Ya-Nan Jin, Zhu Chen, Xue-Gang Li. Fitoterapia。 2012, Vol 83, Iss 1, pp 67-73.
35. Yafei Denga, Kai He, Xiaoli Ye, Xin Chen, Jing Huang, Xuegang Li, Lujiang Yuan*, Yalan Jin,Qing Jin, Panpan Li. Saponin rich fractions from Polygonatum odoratum (Mill.) Druce with more potential hypoglycemic effects. Journal of Ethnopharmacology,141 (2012) 228– 233。
36. Chen Zhu, Ye Xiaoli, Yi jun, Chen Xin, Li Xuegang. Synthesis of 9-O-glycosyl-berberine derivatives and bioavailability evaluation. Med Chem Res, 2012.V21(8):1641~1646.
37. Baoshun Zhang,Tingting Chen,Zhu Chen,Mingxue Wang,Dengyu Zheng,Jinfeng Wua,Xiaofei Jiang, Xuegang Li。Synthesis and anti-hyperglycemic activity of hesperidin derivatives。Bioorganic & Medicinal Chemistry Letters。2012,22:7194-7197。
38. Kai He, Xuegang Li, Xiaoli Ye, Lujiang Yuan, Xiaoduo Li, Xin Chen, Yafei Deng. A mitochondria-based method for the determination of antioxidant activities using 2’,7’‐dichlorofluorescin diacetate oxidation. Food Research International 48 (2012) 454–461.
39. Xiaoli Ye,Kai He,Xiaokang Zhu,Baoshun Zhang ,Xin Chen,Jun Yi,Xuegang Li. Synthesis and antihyperlipidemic efficiency of berberine-based HMG-CoA Reductase Inhibitorreductase inhibitor。Med Chem Res, (2012) 21:1353–1362.
40. Jinfeng Tian a, Xiaoli Ye a, b,, Xuegang Li a,*。Preparative isolation and purification of harpagoside and angroside C from the root of Scrophularia ningpoensis Hemsley by high-speed counter-current chromatography。J. Sep. Sci. 2012, 35, 2659–2664。
41. Teng-Wen Ma, Xiao-Li Ye, Xue-Gang Li, Bao-Shun Zhang, Xiao-Fei Jiang and Zu Chen. Synthesis and Antimicrobial Activity of 8-Alkylpalmatine Derivatives.Letters in Drug Design & Discovery, 2011, 8,464~468.
42. Yang yong, Ye xiao-li, Zhang Bao-shun, Li Xue-gang. Effect of 8-alkyberberine homologues on erythrocyte membrane. Indian Journal of experimemtal biology. 2011. 49(5):319~323.
43. Xiaoli Ye, Xin Chen, Kai He, Jun Yi, Xuegang Li, Ping Li and Xiaohong Wang. Study of antihyperlipidemic effect on rabbits of 8-alkylberberine derivatives. Journal of Medicinal Plants Research. 2011, 5(8), 1390-1394.
44. Baoshun Zhang, Xiaoli Ye, Zhu Chen, Xiaofei Jiang, Lujiang Yuan, Jun Yi, Xuegang Li. Synthesis and antimicrobial activity of 7-alkoxyhesperetin derivatives. Med Chem Res, (2011) 20:1200–1205
45. Xiao-fei Jiang, xiao-li Ye, Baoshun Zhang and Xue-gang Li. Synthesis and Antimicrobial Activity of 8-Alkyl Coptisine Derivatives. Asian Journal of Chemistry. 2011, 23(9): 3849~3852
46. Kai He,Xuegang Li,Xin Chen,Xiaoli Ye,Jing Huang,Yanan Jin,Panpan Li,Yafei Deng,Qing Jin,Qing Shi,Hejing Shu 。Evaluation on Antidiabetic Potential of Selected traditional Chinese Medicines in STZ-induced Diabetic Rats。Journal of Ethnopharmacology. 137:1135~1142。2011.
47. Xiao-li Ye,Wen-wen Huang,Zhu chen,Xue-gang Li,Ping Li,Ping Lan,Liang Wang,Ying Gao,Zhong-qi Zhao,Xin Chen。Synergetic Effect and Structure- Activity Relationship of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors from Crataegus pinnatifida Bge. J. Agric. Food Chem. 2010. 58 (5):3132–3138.
48. H.-P. Wei, X.-L. Ye, Z. Chen, Y.-J. Zhong, P.-M. Li, S.-C. Pu, X.-G. Li. Synthesis and pharmacokinetic evaluation of novel N-acyl-cordycepinderivatives with a normal alkyl chain. European Journal of Medicinal Chemistry, 2009, 44:665~669。
49. Li-Jun Wang, Xiao-Li Ye, Zhu Chen, Xue-Gang Li, Qing-Lei Sun, Bao-Shun Zhang, Xiao-Gang Cao, Gang Yu, Xiao-Hua Niu. Synthesis and antimicrobial activity of 3-octyloxy -8-alkyljatrorrhizine derivatives. Journal of Asian Natural Products Research, 2009, 11(4):365~370。
50. G.-J. He a, X.-L. Ye, X. Moua, Z. Chen, X.-G. Li a。 Synthesis and antinociceptive activity of capsinoid derivatives。European Journal of Medicinal Chemistry, 2009。44:3345~3349。
51. Zhu Chen, Xue-Gang Li, Yong-Sheng Xie and Xiao-Li Ye. 9-O-Butyl-berberrubine bromide. Acta Crystallographica Section E, 2009, E65,o1370。
52. Xiaoli Yea, Li Xua, Xuegang Li b,∗, Zhu Chenb, Baoshun Zhangb, Lujiang Yuanb, Xing Chenb, Huajin Zhanga, Wen Changa, Shengliang Suna。 Antibacterial mechanism of houttuyfonate homologues against Bacillus subtilis。Colloids and Surfaces A: Physicochemical and Engineering Aspects。350 (2009):130–135。
53. WANG Li-Jun,YE Xiao-Li, LI Xue-Gang*, YU Gang, Cao Xiao-Gang,liang yan-tin,zhang hua-san。Synthesis and Antimicrobial Activity of 3-alkoxy-jatrorrhizine Derivatives。Planta Medica, 2008, 74:290~292。
54. Ye Xiaoli, Li Xuegang, Lujiang Yuan, Linhu Ge, Shaobo Zhou. Interaction between houttuyfonate homologues with the cell membrane of Gram-positive and Gram-negative Bacteria. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2007,301:412~418.
55. Yuan Luijiang,Ye Xiaoli, Li Xuegang. Effect of octadecanoyl acetal sodium sulfite series with different numbers of double bond on their immunologic and surface activities. Journal of Asian Natural Products Research, 2007, 9(1):49~58.
56. Yang Yong, Ye Xiaoli, Li Xuegang, Zhen Jing, Zhang Baoshun, Yuan Lujiang. Studies on Synthesis and Antimicrobial Activity of 8-alkyl Berberine Derivatives with Long Aliphatic Chain. Planta Medica, 2007, 73:602~604.
57. Ye Xiaoli, Li Xuegang . Interaction between houttuyfonate homologues and erythrocyte plasma membrane of rabbit in vitro. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2006,279:218~224.
58. 薛东芳, 邹宗尧, 陈彪, 王燕枝, 吴昊, 叶小利*,李学刚. 黄连总生物碱与小檗碱对嗜水气单胞菌细胞膜损伤机制的研究. 中国中药杂志, 2015,40(9): 1787-1792
59. 陈彪, 薛东芳, 韩冰, 寇淑鸣, 叶小利*, 李学刚. 黄连碱对胆固醇代谢关键基因的调节作用. 中国中药杂志, 2015,40(8):1548-1553
60. 韩冰,寇淑鸣,陈彪,彭耀宗,王越,韩玉龙,叶小利*,李学刚*. 高效快速降脂动物模型研究. 中国中药杂志, 2015,40(22):4446
61. 周霞,彭耀宗,黄涛,李玲,牟绍霞,寇淑鸣,李学刚*. 黄连生物碱对体外培养的小鼠腹腔巨噬细胞的影响.中国中药杂志,2015, 40(23):4660
62. 胡宇莉,陈超,邹宗尧,李学刚,叶小利。8-十六烷基小檗碱与小檗碱的大鼠药代动力学和组织分布比较研究。药学学报,2014, 49 (11): 1582 −1587。
63. 吴昊,王燕枝,王德珍,庞婕,叶小利*,李学刚。黄连生物碱对金黄地鼠血脂代谢及低密度脂蛋白受体基因表达的影响。中国中药杂志,39(11):1373-1381,2014。
64. 陈红英,李学刚,叶小利,晋亚楠,黄 静,吴金凤。黄连中胆碱的分离及其对小檗碱在HepG2细胞中糖代谢作用的影响.中国中药杂志,2012,37(12):26~31。
65. 张保顺,叶小利,陈竹,姚波,谭平,李学刚。有特色已完成的甲基橙皮素-7-烷基醚同系物的合成及其抗炎作用。药学学报,2011, 46 (7):811~817.
专利、著作版权等
国际专利技术
1、甘薯谷甾醇糖苷饱和脂肪酸、提取物及其制备方法与应用。发明人:叶小利、李学刚、李滟临、李亚松。中国技术发明专利,申请号:201711390608.X。(国际专利申请号:PCT/CN2018/08/081664;2018年4月03日)
2、甘薯谷甾醇糖苷不饱和脂肪酸、提取物及其制备方法和应用。发明人:叶小利、李学刚、李滟临、李亚松。中国技术发明专利,申请号:201711390595.6。(国际专利申请号:PCT/CN2018/08/081594;2018年4月02日)
专利技术
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