教育背景
1996年于中山大学获得药理学博士学位
工作经历
1999年赴美国科罗拉多大学从事2年博士后工作
项目课题经历
黎教授作为负责人获得了包括国家自然科学基金重点项目、“重大新药创制”科技重大专项、“973”计划、国家自然科学基金B类杰青、国家自然科学基金-广东省政府联合资助基金、广东省科技厅重点领域研发计划、广东省自然团队项目等二十多项基金资助,其中包括2018年度获得的两项重大项目:国家自然科学基金-广东联合基金集成项目(U1801681,1180万)及广东省科技厅重点领域研发计划“脑科学与类脑研究”专项项目
论文、成果、著作等
近年来发表了40余篇SCI论文,其中黎教授作为第一作者或通讯作者在J Neurosci,Mol Cell Biol,J Biol Chem, Cell Death Differ, Proteomics和 Neuropharmacology等国际核心杂志发表了30余篇文章,并在Drug News Perspect上发表了相关专题综述。以第一/通讯作者发表SCI论文:# 通讯作者
Chen W, Huang Q, Ma S#, Li M#: Progress in dopaminergic cell-replacement and regenerative strategies for Parkinson’s disease. ACS Chem Neurosci 2018 in press. Yu Q, Huang Q, Du X, Xu S, Li M# and Ma S#. Early activation of Egr-1 promotes neuroinflammation and dopaminergic neurodegeneration in an experimental model of Parkinson's disease. Exp Neurol. 2018, 302:145-154. Huang Q, Du X, He X, Yu Q, Hu K, Breitwieser W, Shen Q, Ma S#, Li M#. Jnk-mediated activation of atf2 contributes to dopaminergic neurodegeneration in the mptp mouse model of parkinson's disease. Exp Neurol. 2016, 277:296-304. Wu R, Chen H, Ma J, He Q, Huang Q, Liu Q, Li M#, Yuan Z#. C-abl-p38alpha signaling plays an important role in mptp-induced neuronal death. Cell Death Differ. 2016, 23(3):542-552. Ma S, Liu S, Huang Q, Xie B, Lai B, Wang C, Song B, and Li M#. Site-specific phosphorylation protects GSK-3β from calpain-mediated truncation of its N- and C-termini. J Biol Chem. 2012;287:22521-32 Xie B, Wang C, Zheng Z, Song B, Ma C, Thiel G, and Li M#. Egr-1 transactivates Bim gene expression to promote neuronal apoptosis. J Neurosci.2011; 31:5032-5044 Song B, Lai B, Zheng Z, Zhang Y, Luo J, Wang C, Chen Y, Woodgett J, and Li M#. Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. J Biol Chem.2010;285:41122-34. Yuan Z, Gong S, Luo J, Zheng Z, Song B, Ma S, Guo J, Hu C, Thiel G, Vinson C, Hu CD, Wang Y, Li M#. Opposing roles for ATF2 and c-Fos in c-Jun-mediated neuronal apoptosis. Mol Cell Biol. 2009;29:2431-2442. Liu W, Zhou XW, Liu S, Hu K, Wang C, He Q, Li M#. Calpain-truncated CRMP-3 and -4 contribute to potassium deprivation-induced apoptosis of cerebellar granule neurons. Proteomics. 2009;9:3712-3728. Ma C, Ying C, Yuan Z, Song B, Li D, Liu Y, Lai B, Li W, Chen R, Ching YP, Li M#. dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons. J Biol Chem. 2007;282:30901-30909. Song B, Xie B, Wang C, Li M#. c-Jun induction is independent of Egr during cerebellar granule neuron apoptosis. Neuroreport. 2012; 23:67-72. Song B, Xie B, Wang C, Li M#. Caspase-3 is a target gene of c-Jun:ATF2 heterodimers during apoptosis induced by activity deprivation in cerebellar granule neurons. Neurosci Lett. 2011; 505:76-81. Mei Y, Yuan Z, Song B, Li D, Ma C, Hu C, Ching YP, Li M#. Activating transcription factor 3 up-regulated by c-Jun NH(2)-terminal kinase/c-Jun contributes to apoptosis induced by potassium deprivation in cerebellar granule neurons. Neuroscience. 2008;151:771-779. Wang W, Yang Y, Ying C, Li W, Ruan H, Zhu X, You Y, Han Y, Chen R, Wang Y, Li M#. Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity. Neuropharmacology. 2007;52:1678-1684. Yuan Z, Mei Y, Zhou J, Tan M, Song B, Ma C, Ying C, Li D, Ching YP, Li M#. E2F1 is not essential for apoptosis induced by potassium deprivation in cerebellar granule neurons. Neurosci Lett. 2007;424:155-159. Song B, Ma C, Gong S, Yuan Z, Li D, Liu W, Li W, Chen R, Zhu X, Zeng J, Han Y, Li M#. Extracellular signal-regulated kinases are not involved in activity-dependent survival or apoptosis in cerebellar granule neurons. Neurosci Lett. 2006;407:214-218. Yang LL, Liu XQ, Liu W, Cheng B, Li M#. Comparative analysis of whole saliva proteomes for the screening of biomarkers for oral lichen planus. Inflamm Res. 2006;55:405-407. Shi L, Gong S, Yuan Z, Ma C, Liu Y, Wang C, Li W, Pi R, Huang S, Chen R, Han Y, Mao Z, Li M#. Activity deprivation-dependent induction of the proapoptotic BH3-only protein Bim is independent of JNK/c-Jun activation during apoptosis in cerebellar granule neurons. Neurosci Lett. 2005;375:7-12. Xie Y, Liu Y, Ma C, Yuan Z, Wang W, Zhu Z, Gao G, Liu X, Yuan H, Chen R, Huang S, Wang X, Zhu X, Mao Z, Li M#. Indirubin-3'-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons. Neurosci Lett. 2004;367:355-359. Wang W, Shi L, Xie Y, Ma C, Li W, Su X, Huang S, Chen R, Zhu Z, Mao Z, Han Y, Li M#. SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease. Neurosci Res. 2004;48:195-202. Wang W, Ma C, Mao Z, Li M#. JNK inhibition as a potential strategy in treating Parkinson's disease. Drug News Perspect. 2004;17:646-654. Li M, Linseman DA, Allen MP, Meintzer MK, Wang X, Laessig T, Wierman ME, Heidenreich KA. Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons. J Neurosci. 2001;21:6544-6552. Li M, Wang X, Meintzer MK, Laessig T, Birnbaum MJ, Heidenreich KA. Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta. Mol Cell Biol. 2000;20:9356-9363.
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