中山医科大学临床医学专业本科和医学病毒学专业博士研究生毕业

1993年到美国接受博士后训练，2001年起受聘于匹兹堡大学医学院病理系，任助理教授，从事分子肿瘤学、分子病毒学和细胞生物学的教学与科研。在美国做博士后研究和任教13年后，2005年受聘为“长江学者”特聘教授，全职归国到中山大学中山医学院工作

目前承担国家级和部省市等各级纵向科研项目经费超过一千五百万元。

以通讯作者迄今（2019年）已在国际主流学术期刊发表论文130篇，其中包括Nature Cell Biology、Journal of Clinical Investigation、PNAS、Nature Communications、Cancer Research、Oncogene、Molecular Cell Biology、Journal of Virology和Journal of Infectious Diseases等重要学术期刊 学术论著与教材：
近五年发表的代表性学术论文（通讯作者）：


1. Guan H, Zhu T, Wu S, Liu S, Liu B, Wu J, Cai J, Zhu X, Zhang X, Zeng M, Li J, Song E, Li M*. Long noncoding RNA LINC00673-v4 promotes aggressiveness of lung adenocarcinoma via activating WNT/β-catenin signaling. Proceedings of National Academy of Science USA, 116(28): 14019-14028, 2019.

2. Liu L, Yang Y, Liu S, Tao T, Cai J, Wu J, Guan H, Zhu X, He Z, Li J, Song E, Zeng M, Li M*. EGF-induced nuclear localization of SHCBP1 activates β-catenin signaling and promotes cancer progression. Oncogene. 38(5):747-764, 2019.

3. Cai J, Li R, Xu X, Zhang L, Lian R, Fang L, Huang Y, Feng X, Liu X, Li X, Zhu X, Zhang H, Wu J, Zeng M, Song E, He Y, Yin Y, Li J, Li M*. CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy. Nature Cell Biology. 20(4):465-478, 2018.

4. He Z, Chen J, Zhu X, An S, Dong X, Yu J, Zhang S, Wu Y, Li G, Zhang Y, Wu J, Li M*. NLRP3 Inflammasome Activation Mediates Zika Virus-Associated Inflammation. Journal of Infectious Diseases. 217(12):1942-1951, 2018.

5. Cai J, Fang L, Huang Y, Li R, Xu X, Hu Z, Zhang L, Yang Y, Zhu X, Zhang H, Wu J, Huang Y, Li J, Zeng M, Song E, He Y, Zhang L, Li M*. Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC. Nature Communications. 8:15870, 2017.

6. Ying Z, Tian H, Li Y, Lian R, Li W, Wu S, Zhang HZ, Wu J, Liu L, Song J, Guan H, Cai J, Zhu X, Li J, Li M*. CCT6A suppresses SMAD2 and promotes pro-metastatic TGF-β signaling. Journal of Clinical Investigation. 127(5):1725-1740, 2017.

7. Liu L, Guan H, Li Y, Ying Z, Wu J, Zhu X, Song L, Li J, Li M*. Astrocyte Elevated Gene 1 Interacts with Acetyltransferase p300 and c-Jun to Promote Tumor Aggressiveness. Molecular Cell Biology. 37(5): e00456-16, 2017.

8. He Z, Zhu X, Wen W, Yuan J, Hu Y, Chen J, An S, Dong X, Lin C, Yu J, Wu J, Yang Y, Cai J, Li J, Li M*. Dengue Virus Subverts Host Innate Immunity by Targeting Adaptor Protein MAVS. Journal of Virology. 90(16):7219-7230, 2016.

9. Fang L, Cai J, Chen B, Wu S, Li R, Xu X, Yang Y, Guan H, Zhu X, Zhang L, Yuan J, Wu J, Li M*. Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling. Nature Communications. 6:8640, 2016.

10. Wen W, He Z, Jing Q, Hu Y, Lin C, Zhou R, Wang X, Su Y, Yuan J, Chen Z, Yuan J, Wu J, Li J, Zhu X, Li M*. Cellular microRNA-miR-548g-3p modulates the replication of dengue virus. Journal of Infection. 70(6):631-640, 2015