颜教授于1987年任职于中山大学药理教研室，1991年赴美国国立卫生研究所精神卫生研究所(NIMH/NIH)作访问科学家，1994年后先后在美国礼来公司中枢神经系统研究所和美国印第安那大学药理和毒理系做访问科学家，1996年回国享受国务院特殊津贴，并获“国家杰出青年科学基金”资助

先后主持国家杰出青年基金、863重点项目、国家自然科学基金重点项目、广东省科技厅关键领域重点攻关项目、广东省自然科学基金研究团队项目等国家省部级项目25项。

在肿瘤和神经领域的主流学术（SCI收录）杂志发表论文90余篇，其中通讯/共同通讯作者论文70篇，第一作者论文10篇，包括Nature Biotechanology、Nature Communications、PNAS（2篇）、Journal of Neuroscience、Oncogene、International journal of cancer、Molecular Therapy、Molecular Pharmacology（2篇）等。参编外文脑肿瘤学领域专著2部 代表性论文：

1 Guangmei Yan*, Guojie Zhang, Xiaodong Fang, Yanfeng Zhang, Cai Li, Fei Ling, David N Cooper, Qiye Li, Yan Li, Alain J van Gool, Hongli Du, Jiesi Chen, Ronghua Chen, Pei Zhang, Zhiyong Huang, John R Thompson, Yuhuan Meng, Yinqi Bai, Jufang Wang, Min Zhuo, Tao Wang, Ying Huang, Liqiong Wei, Jianwen Li, Zhiwen Wang, Haofu Hu, Pengcheng Yang, Liang Le, Peter D Stenson, Bo Li, Xiaoming Liu, Edward V Ball, Na An, Quanfei Huang, Yong Zhang, Wei Fan, Xiuqing Zhang, Yingrui Li, Wen Wang, Michael G Katze, Bing Su, Rasmus Nielsen, Huanming Yang, Jun Wang, Xiaoning Wang & Jian Wang. Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nature Biotechnology, 2011, 29: 1019-1025. (IF = 39.08)

2 Yuan Lin#, Haipeng Zhang#, Jiankai Liang#, Kai Li, Wenbo Zhu, Liwu Fu, Fang Wang, Xiaoke Zheng, Huijuan Shi, Sihan Wu, Xiao Xiao, Lijun Chen, Lipeng Tang, Min Yan, Xiaoxiao Yang, Yaqian Tan, Pengxin Qiu, Yijun Huang, Wei Yin, Xinwen Su, Haiyan Hu, Jun Hu*, and Guangmei Yan*. Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers.PNAS, 2014,111(42):4504-4512.. (IF: 9.809)

3 Yan Li, Wei Yin, Xia Wang, Wenbo Zhu, Yijun Huang and Guangmei Yan*: Cholera toxin induces malignant glioma cell differentiation via the PKA/CREB pathway. PNAS, 2007, 104: 13438-43. (IF: 9.809)

4 Sihan Wu, Yuan Lin, Dong Xu, Jiesi Chen, Minfeng Shu, Yuehan Zhou, Wenbo Zhu, Xingwen Su, Yuxi Zhou, Pengxin Qiu and Guangmei Yan*. MiR-135a Functions as a Selective Killer of Malignant Glioma. Oncogene, 2012, 31: 3866-3874. (IF = 8.559)

5 Haiyan Hu, Yuehan Zhou, Tiandong Leng, Ailing Liu, Youqiong Wang, Xiuhua You, Jingkao Chen, Lipeng Tang, Wenli Chen, Pengxin Qiu, Wei Yin, Yijun Huang, Jingxia Zhang, Liwei Wang, Hanfei Sang and Guangmei Yan*. A major cholesterol metabol i te cholestane-3β, 5α, 6β-triolfunctions as an endogenous neuroprotectant. The Journal of Neuroscience, August 20, 2014, 34(34): 11426 –11438. (IF: 6.747)

6 Kai Li#, Haipeng Zhang#, Jianguang Qiu, Yuan Lin, Jiankai Liang, Xiao Xiao,Liwu Fu, Fang Wang, Jing Cai, Yaqian Tan, Wenbo Zhu, Wei Yin, Bingzheng Lu, Fan Xing, Lipeng Tang, Min Yan, Jialuo Mai, Yuan Li, Wenli Chen, Pengxin Qiu, Xingwen Su, Guangping Gao, Phillip W L Tai, Jun Hu* and Guangmei Yan*. Activation of cyclic adenosine monophosphate pathway increases the sensitivity of cancer cells to the oncolytic virus M1. Molecular Therapy, 2016, 24(1): 156–165. (IF =6.227)

学术论著与教材：
学术论著：

1. Wenbo Zhu and Guangmei Yan (2011). The Molecular Mechanism for Differentiation Therapy of Malignant Glioma, Brain Tumors - Current and Emerging Therapeutic Strategies, Ana L. Abujamra (Ed.), ISBN: 978-953-307-588-4, InTech. Available from: http://www.intechopen.com /articles /show /title /the-molecular-mechanism-for-differentiation-therapy-of-malignant-glioma.

2. Sihan Wu, Wenbo Zhu and Guangmei Yan (2012). Evolvement of microRNAs as therapeutic targets for malignant gliomas, Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications. Terry Lichtor. (Ed.),ISBN 980-953-307-523-0, InTech.





主编教材：

1. 2004年主编高等教育出版社《药理学》；

2. 2009年主编高等教育出版社《药理学》。

获得国家发明专利9项