教育背景
1999年毕业于华西医科大学,获理学博士学位
工作经历
1999年至2004年先后在中山医科大学和美国芝加哥大学从事博士后研究工作
项目课题经历
作为负责人承担国家重大研究计划、国家杰出青年基金,国家自然科学基金,省部级重大项目20余项,
论文、成果、著作等
在Hepatology, Mol Psychiatry, Leukemia, Cell Res, PNAS, Biomaterials, Mol Ther等发表SCI收录论文50余篇 学术论著与教材:
1. Zhang X, Huang W, Chen X, Lian Y, Wang J, Cai C, Huang L, Wang T, Ren J*, Xiang AP*. CXCR5-Overexpressing Mesenchymal Stromal Cells Exhibit Enhanced Homing and Can Decrease Contact Hypersensitivity. Mol Ther. 2017 Jun 7;25(6):1434-1447.
2. Lin BL, Chen JF, Qiu WH, Wang KW, Xie DY, Chen XY, Liu QL, Peng L, Li JG, Mei YY, Weng WZ, Peng YW, Cao HJ, Xie JQ, Xie SB, Xiang AP*, Gao ZL*.Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells for HBV-Related Acute-on-Chronic Liver Failure: A Randomized Controlled Trial. Hepatology. 2017 Jul;66(1):209-219.
3. Qin A, Lai DH, Liu Q, Huang W, Wu YP, Chen X, Yan S, Xia H, Hide G, Lun ZR*, Ayala FJ*, Xiang AP*. Guanylate-binding Protein 1 (GBP1) Contributes to the Immunity of Human Mesenchymal Stromal Cells against Toxoplasma gondii. Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1365-1370.
4. Wang J, Zhang B, Wu H, Cai J, Sui X, Wang Y, Li H, Qiu Y, Wang T, Chen Z, Zhu Q, Xia H, Song W*, Xiang AP*. CD51 correlates with the TGF-beta pathway and is a functional marker for colorectal cancer stem cells. Oncogene. 2017 Mar;36(10):1351-63.
5. Li W, Huang L, Zeng J, Lin W, Li K, Sun J, Huang W, Chen J, Wang G, Ke Q, Duan J, Lai X, Chen R, Liu M, Liu Y, Wang T, Yang X, Chen Y, Xia H*, Xiang AP*. Characterization and transplantation of enteric neural crest cells from human induced pluripotent stem cells. Mol Psychiatry. 2016 Oct 25. doi: 10.1038/mp.2016.191.
6. Liao Y, Lei J, Liu M, Lin W, Hong D, Tuo Y, Hua Jiang M, Xia H, Wang M*, Huang W*, Xiang AP*. Mesenchymal Stromal Cells Mitigate Experimental Colitis via Insulin-like Growth Factor Binding Protein 7-mediated Immunosuppression. Mol Ther. 2016 Oct;24(10):1860-1872.
7. Ke Q, Li W, Lai X, Chen H, Huang L, Kang Z, Li K, Ren J, Lin X, Zheng H, Huang W, Ma Y, Xu D, Chen Z, Song X, Lin X, Zhuang M, Wang T, Zhuang F, Xi J, Mao FF, Xia H, Lahn BT, Zhou Q*, Yang S*, Xiang AP*. TALEN-based generation of a cynomolgus monkey disease model for human microcephaly. Cell Res. 2016 Sep;26(9):1048-61.
8. Wang J, Cai J, Huang Y, Ke Q, Wu B, Wang S, Han X, Wang T, Wang Y, Li W, Lao C, Song W, Xiang AP*. Nestin regulates proliferation and invasion of gastrointestinal stromal tumor cells by altering mitochondrial dynamics. Oncogene. 2016 Jun 16;35(24):3139-50.
9. Jiang MH, Li G, Liu J, Liu L, Wu B, Huang W, He W, Deng C, Wang D, Li C, Lahn BT, Shi C*, Xiang AP*. Nestin+ kidney resident mesenchymal stem cells for the treatment of acute kidney ischemia injury. Biomaterials. 2015 May;50: 56-66.
10. Peng Y, Chen X, Liu Q, Zhang X, Huang K, Liu L, Li H, Zhou M, Huang F, Fan Z, Sun J, Liu Q, Ke M, Li X, Zhang Q, Xiang AP*. Mesenchymal stromal cells infusions improve refractory chronic graft versus host disease through an increase of CD5+ regulatory B cells producing interleukin 10. Leukemia. 2015 Mar; 29(3):636-46.
11. Li WQ, Huang LH, Lin WY, Ke Q, Chen R, Lai XQ, Wang XY, Zhang JF, Jiang MH, Huang WJ, Wang T, Yang XS, Chen Y, Song W*, Xiang AP*. Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells. Biomaterials. 2015 Jan;39:75-84.
12. Jiang MH, Cai B, Tuo Y, Wang J, Zang ZJ, Tu X, Gao Y, Su Z, Li W, Li G, Zhang M, Jiao J, Wan Z, Deng C, Lahn BT, Xiang AP*. Characterization of nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction. Cell Res. 2014 Dec;24(12):1466-85.
13. Chen F, Cai B, Gao Y, Yuan XF, Cheng FY, Wang T, Jiang MH, Zhou YJ, Lahn BT, Li WQ, Xiang AP*. Suicide gene-mediated ablation of tumor-initiating mouse pluripotent stem cells. Biomaterials. 2013 Feb;34(6): 1701-1711.
14. Cheng F, Ke Q, Chen F, Cai B, Gao Y, Ye C, Wang D, Zhang L, Lahn BT, Li W, Xiang AP*. Protecting against wayward human induced pluripotent stem cells with a suicide gene. Biomaterials. 2012 Apr;33(11):3195-204.
15. Weng JY, Du X, Peng YW, Wang Z, Wu SJ, Lu ZS, Lin W, Xiang AP*. Mesenchymal stem cell as salvage treatment for refractory chronic GVHD. Bone Marrow Transplant. 2010 Dec;45(12):1732-40.
专利、著作版权等
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