2007年于武汉大学生命科学学院获得学士学位；2013年于中国科学院生物物理研究所（中国科学院大学）获得生物化学与分子生物学博士学位；

2013年7月至2018年在加拿大蒙特利尔临床研究所(Montreal Clinical Research Institute)从事博士后研究工作

目前已经获得多个科研项目支持，包括中组部 “千人计划” 青年项目、 中山大学“百人计划”、科技部重点研发项目、中山大学青年教师重点培育项目等。科研项目：



1. 中组部“千人计划”青年项目，2018-2021，主持，在研。

2. 中山大学“百人计划”项目，2018-2023, 主持，在研。

3. 科技部重点研发项目，2019-2023，参与，在研。

4. 中山大学青年教师重点培育项目，2019.1-2020.12，主持，在研。

目前以第一和主要作者的身份发表多篇高影响力的学术论文和专著，在Nature，J. Exp. Med., J. Immunology, Trend in Immunology, Clinical Cancer Research, J. Bio. Chem.等一流期刊上发表多项重要成果

学术论著(*共同第一作者，IF影响因子)



1. Veillette A and Chen J. SIRPa–CD47 Immune Checkpoint Blockade in Anticancer Therapy. Trends in Immunololy. 2018;39(3):173-184. (IF=14.188)

2. Chen J, Zhong MC, Guo H, Davidson D, Mishel S, Lu Y, Rhee I, Pérez-Quintero LA, Zhang S, Cruz-Munoz ME, Wu N, Vinh DC, Sinha M, Calderon V, Lowell CA, Danska JS, Veillette A. SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin. Nature 544, 493-497. (2017). (IF=43.070)

Highlighted by: Cancer Discovery, Science Signaling, Cancer Immunology Research.

3. Chen J*, Hao L*, Li C, Ye B, Du Y, Zhang H, Long B, Zhu P, Liu B, Yang L, Li P, Tian Y, Fan Z. The Endoplasmic Reticulum Adaptor Protein ERAdP Initiates NK Cell Activation via the Ubc13-Mediated NF-kB Pathway. The Journal of Immunology. 2015, 194,1292-1303. (IF=5.26)

4. Guo Y*, Chen J*, Shi L, Fan Z. Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells. Journal of Immunology. 2010, 185(9): 5348-5359. (IF=5.26)

5. Roussel L, Landekic M, Golizeh M, Gavino C, Zhong MC, Chen J, Faubert D, Blanchet-Cohen A, Dansereau L, Parent MA, Marin S, Luo J, Le C, Ford BR, Langelier M, King IL, Divangahi M, Foulkes WD, Veillette A, Vinh DC. Loss of human ICOSL results in combined immunodeficiency. The Journal of Experimental Medicine. 2018; 215(12):3151-3164. (IF=11.991)

6. Guo H, Cranert SA, Lu Y, Zhong MC, Zhang S, Chen J, Li R, Mahl SE, Wu N, Davidson D, Waggoner SN, Veillette A. Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. The Journal of Experimental Medicine. 2016, 213(10):2187-207. (IF=11.991)

7. Veillette A., Chen J, Lu Y. 2016. SLAM Family Receptors. In: Ratcliffe, M.J.H. (Editor in Chief), Encyclopedia of Immunobiology, Vol. 2, pp. 415–423. Oxford: Academic Press.

8. Li C, Yang Z, Du Y, Tang H, Chen J, Hu D, Fan Z. BCMab1, A Monoclonal Antibody against Aberrantly Glycosylated Integrin α3β1, Has Potent Antitumor Activity of Bladder Cancer In Vivo. Clinical Cancer Research. 2014, 20(15): 4001-4013. (IF=9.619)

9. Li M, Xia P, Du Y, Liu S, Huang G, Chen J, Zhang H, Hou N, Cheng X, Zhou L, Li P, Yang X, Fan Z.T-cell Immunoglobulin and ITIM Domain (TIGIT) Receptor/Poliovirus Receptor (PVR) Ligand Engagement Suppresses Interferon-γ Production of Natural Killer Cells via β-Arrestin 2-mediated Negative Signaling. Journal of Biological Chemistry. 2014, 289(25): 17647-17657. (IF=4.125)

10. Qu Q, Chen J, Wang Y, Gui W, Wang L, Fan Z, Jiang T. Structural insights into the allosteric activation mechanism of p75NTR. PLoS One 2013, 8(3):e57839. (IF=2.806)

11. Guo Y, Chen J, Zhao T, Fan Z. Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity. Molecular Immunology. 2008, 45(8): 2225-2235. (IF=3.188)

并已申请相关领域国际及中国专利3项。专利：



1. Chen J, Veillette A. (2016) Methods of preventing or treating non-hematopoietic slamf7 positive and slamf7 negative cancers. (PCT/CA2017050457)

2. Li C, Fan Z, Zhang H, Dai Z, Tang H, Chen J. (2015) The Application of a human bladder cancer marker and its antibody. (US 9073995 B2).