本科及硕士毕业于中山大学生命科学学院。博士毕业于美国约翰霍普金斯大学医学院，获分子生物学与遗传学博士学位

曾在美国霍华德休斯医学研究所(HHMI)从事博士后研究

获得科研项目：
1. 基于CRISPR-Cas9遗传筛选的HIV-1潜伏感染的分子机制研究，广东省杰出青年科学基金，主持，在研

2. CTL选择压力下HIV-1病毒储存库的演进规律及其个性化清除策略研究，国家自然科学基金面上项目，主持，在研

3. HIV-1建立潜伏感染的分子机制研究，中山大学青年教师重点培育项目，主持，结题

4. 杀伤性T细胞选择压力下HIV-1病毒储存库的动态变化研究，广东省自然科学基金面上项目，主持，在研

5. 肿瘤精准化免疫治疗创新团队，广东省“珠江人才计划”引进创新创业团队，核心成员，在研

6. TCR-T与CAR-T联合免疫治疗清除储存库临床研究，国家科技重大专项子课题，课题骨干，在研

代表性论文（通讯或第一作者）：

Yu F*, Li Q*, Chen X, Liu J, Li L, Li B, Liu B, Zhang J, Zhang X, Liu Z, Luo H, Tang XP, Cai W, Zhang H#, Deng K#. X4-tropic latent HIV-1 is enriched in peripheral follicular helper T cells and is correlated with disease progression. Journal of Virology 2020; 94: e01219-19 (#Corresponding author) (IF: 4.32) Li X, Liu Z, Li Q, Hu R, Zhao L, Yang Y, Zhao J, Huang Z, Gao H, Li L#, Cai W#, Deng K#. CD161+ CD4+ T cells harbor clonally expanded replication-competent HIV-1 in antiretroviral therapy-suppressed individuals. mBio 2019; 10: e02121-19. (#Corresponding author) (IF: 6.75) Shan L*, Deng K*, Gao H, Xing S, Capoferri AA, Durand CM, Rabi SA, Laird GM, Kim M, Hosmane NN, Yang HC, Zhang H, Margolick JB, Li L,Cai W, Ke R, Flavell RA, Siliciano JD, and Siliciano RF. Transcriptional reprogramming during effector-to-memory transition renders CD4+ T cells permissive for latent HIV-1 infection. Immunity 2017; 47: 766-775. (*Co-first author) (IF: 21.52) Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, Deeks SG, Strowig T, Kumar P, Siliciano JD, Salzberg SL, Flavell RA, Shan L, Siliciano RF. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature 2015; 517: 381-385. (IF: 43.07) Deng K and Siliciano RF. HIV: Early treatment may not be early enough. Nature 2014; 512: 35-36. (IF: 43.07) Deng K, Zink MC, Clements JE, Siliciano RF. A quantitative measurement of antiviral activity of anti-human immunodeficiency virus type 1 drugs against simian immunodeficiency virus infection: dose-response curve slope strongly influences class-specific inhibitory potential. Journal of Virology 2012; 86:11368-72. (IF: 4.32)


共同作者论文：

Xu L, Wang J, Liu Y, Xie L, Su B, Mou D, Wang L, Liu T, Wang X, Zhang B, Zhao L, Hu L, Ning H, Zhang Y, Deng K, Liu L, Lu X, Zhang T, Xu J, Li C, Wu H, Deng H, Chen H. CRISPR-Edited Stem Cells in a Patient with HIV and Acute Lymphocytic Leukemia. New England Journal of Medicine 2019; 381:1240-1247. (IF: 70.67) Liu B, Zhang X, Zhang W, Wu L, Jing S, Liu W, Xia B, Zou F, Lu L, Ma X, He D, Hu Q, Zhang Y, Deng K, Cai W, Tang X, Peng T, Zhang H, Li L. Lovastatin Inhibits HIV-1-Induced MHC-I Downregulation by Targeting Nef-AP-1 Complex Formation: A New Strategy to Boost Immune Eradication of HIV-1 Infected Cells. Frontiers in Immunology 2019; 10: 2151. (IF: 4.72) Pan T, Song Z, Wu L, Liu G, Ma X, Peng Z, Zhou M, Liang L, Liu B, Liu J, Zhang J, Zhang X, Huang R, Zhao J, Li Y, Ling X, Luo Y, Tang X, Cai W, Deng K, Li L, Zhang H. USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication. eLife 2019; 8: e48318. (IF: 7.55) Ma X, Yang T, Luo Y, Wu L, Jiang Y, Song Z, Pan T, Liu B, Liu G, Liu J, Yu F, He Z, Zhang W, Yang J, Liang L, Guan Y, Zhang X, Li L, Cai W, Tang X, Gao S, Deng K, Zhang H. TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb. eLife 2019; 8: e42426. (IF: 7.55) He R, Hou S, Liu C, Zhang A, Bai Q, Han M, Yang Y, Wei G, Shen T, Yang X, Xu L, Chen X, Hao Y, Wang P, Zhu C, Ou J, Liang H, Ni T, Zhang X, Zhou X, Deng K, Chen Y, Luo Y, Xu J, Qi H, Wu Y, Ye L. Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection. Nature 2016; 537: 412-418. (IF: 43.07) Shan L, Deng K, Shroff NS, Durand CM, Rabi SA, Yang HC, Zhang H, Margolick JB, Blankson JN, Siliciano RF. Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation. Immunity 2012; 36:491-501. (IF: 21.52) Huang J, Deng K, Wu H, Liu Z, Chen Z, Cao S, Zhou L, Ye X, Keefe DL, Liu L. Efficient production of mice from embryonic stem cells injected into 4- or 8- cell embryos by piezo micromanipulation. Stem Cells 2008; 26:1883-1890. (IF: 5.61)