教育背景
赵蔚教授在南京大学获生物学士和博士学位
工作经历
在美国Baylor College of Medicine从事博士后研究,然后来到康奈尔大学Weill医学院附属Methodist医院从事助理研究员工作
项目课题经历
目前主持国家重点研发计划干细胞专项子课题和国家自然科学基金面上项目等多个科研项目。主持或参加的在研科研项目:
1. 国家自然科学基金面上项目,2020-2023,项目负责人
2. 国家自然科学基金面上项目,2018-2021,项目负责人
3. 国家自然科学基金面上项目,2016-2019,项目负责人
4. 国家青千项目(第十一批)2016-2018,项目负责人
5. 国家重点研发计划干细胞及转化研究项目,2017-2021,子课题负责人
6.广东省自然科学基金团队项目,子课题负责人
论文、成果、著作等
迄今已在 Cell,Cancer Research等杂志发表论文30余篇 近年论文发表情况:
N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma. Li F, Yi Y, Miao Y, Long W, Long T, Chen S, Cheng W, Zou C, Zheng Y, Wu X, Ding J, Zhu K, Chen D, Xu Q, Wang J, Liu Q, Zhi F, Ren J, Cao Q, Zhao W. Cancer Res. 2019 Sep 17.
Isoform-specific involvement of Brpf1 in expansion of adult hematopoietic stem and progenitor cells. He Q, Hong M, He J, Chen W, Zhao M, Zhao W. J Mol Cell Biol. 2019 Sep 30.
Epigenetic profiling identifies LIF as a super-enhancer controlled regulator of stem cell-like properties in osteosarcoma. Lu B, He Y, He J, Wang L, Liu Z, Yang J, Gao Z, Lu G, Zou C, Zhao W. Mol Cancer Res. 2019 Oct 15.
BMI1 is directly regulated by androgen receptor to promote castration-resistance in prostate cancer.Zhu S, Zhao D, Li C, Li Q, Jiang W, Liu Q, Wang R, Fazli L, Li Y, Zhang L, Yi Y, Meng Q, Wang W, Wang G, Zhang M, Zu X, Zhao W, Deng T, Yu J, Dong X, Chen K, Cao Q. Oncogene. 2019 Aug 28.
The C/EBPβ-LINC01133 axis promotes cell proliferation in pancreatic ductal adenocarcinoma through upregulation of CCNG1. Huang CS, Chu J, Zhu XX, Li JH, Huang XT, Cai JP, Zhao W, Yin XY. Cancer Lett. 2018 May 1;421:63-72.
NLRP11 attenuates Toll-like receptor signalling by targeting TRAF6 for degradation via the ubiquitin ligase RNF19A. Wu C, Su Z, Lin M, Ou J, Zhao W, Cui J, Wang RF. Nat Commun. 2017 Dec 7;8(1):1977.
A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs.Huang C, Shi J, Guo Y, Huang W, Huang S, Ming S, Wu X, Zhang R, Ding J, Zhao W, Jia J, Huang X, Xiang AP, Shi Y, Yao C.Nucleic Acids Res. 2017 Sep 6;45(15):8647-8660.
Multifunctional nanoparticles for co-delivery of paclitaxel and carboplatin against ovarian cancer by inactivating the JMJD3-HER2 axis. Mo J, Wang L, Huang X, Lu B, Zou C, Wei L, Chu J, Eggers PK, Chen S, Raston CL, Wu J, Lim LY, Zhao W. Nanoscale. 2017 Sep 14;9(35):13142-13152.
USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components. Ning B, Zhao W, Qian C, Liu P, Li Q, Li W, Wang RF. Nat Commun. 2017 Aug 24;8(1):349.
Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation.Li Q, Zou J, Wang M, Ding X, Chepelev I, Zhou X, Zhao W, Wei G, Cui J, Zhao K, Wang HY, Wang RF. Nat Commun. 2014 Dec 22;5:5780.
Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination. Zhao W, Li Q, Ayers S, Gu Y, Shi Z, Zhu Q, Chen Y, Wang HY, Wang RF. Cell. 2013 Feb 28;152(5):1037-50.
专利、著作版权等
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