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王继厂

领域:生物产业 学校:中山大学职称:教授

(1)人类胚胎细胞命运转变的转录后调控机制; (2)内源性逆转录病毒等反转录转座子在灵长类干细胞多能性调控和早期胚胎发育中的生物学功能及其作用机制; (3)灵长类-非灵长类动物异种嵌合障碍和生殖隔离的分子机制; (4)建立早发性婴幼儿癫痫性脑病的干细胞模型,进行治疗探索。...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

本科和硕士就读于南京医科大学,先后获得医学学士学位和医学硕士学位 2015年于德国柏林自由大学获得自然科学博士学位

工作经历

攻读博士学位期间,以Scientist身份在德国马克斯-德尔布吕克分子医学中心进行博士课题研究 博士毕业后,在德国亥姆霍兹联合会的资助下,以Helmholtz Postdoctoral Fellow身份(独立的项目PI),继续在马克斯-德尔布吕克分子医学中心进行科学研究

项目课题经历

经费来源及在研项目:

1. 国家自然科学基金面上项目(2018,项目负责人)

2. 国家重点研发计划——“干细胞及转化研究”专项(2018,课题负责人)

3. 国家重点研发计划——“干细胞及转化研究”专项(2018,学术骨干)

4. “千人计划”青年项目(2017,项目负责人)

5. 广东省“珠江人才计划”引进创新创业团队(2017,核心骨干)

6. 中山大学“百人计划”引进人才科研启动经费(2017,项目负责人)

7. Helmholtz Postodoc Programme(2015,30万欧元,PI)

论文、成果、著作等

学术论著与教材:
(* co-first author; # co-corresponding author)

1. Yasamin Dabiri, Rodrigo A Gama-Brambila, Katerina Taškova, Kristina Herold, Stefanie Reuter, James Adjaye, Jochen Utikal, Ralf Mrowka, Jichang Wang, Miguel A Andrade-Navarro, Xinlai Cheng#. Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs. iScience. 2018, 12: 168-181.

2. Yongming Wang*, Diana Pryputniewicz-Dobrinska*, Enikö Nagy*, Christopher Kaufman, Manvendra Singh, Stephen Yant, Jichang Wang, Anna dalda, M Kay, Zoltán Ivics, Zsuzsanna Izsvák#. Regulated Complex Assembly Safeguards the Fidelity of Sleeping Beauty Transposition. Nucleic Acids Res. 2017;45(1):311-326.

3. Liang Hu*, Jichang Wang*, Hongyi Zhu, Xiaowei Wu, Lu Zhou, Yichen Song, Suhua Zhu, Maojuan Hao, Chao Liu, Yue Fan, Yu Wang, Qingping Li#. Ischemic postconditioning protects the heart against ischemia-reperfusion injury via neuronal nitric oxide synthase in the sarcoplasmic reticulum and mitochondria. Cell Death Dis. 2016; 7: e2222.

4. Jichang Wang, Manvendra Singh, Chuanbo Sun, Daniel Besser, Alessandro Prigione, Zoltán Ivics, Laurence D. Hurst#, Zsuzsanna Izsvák#. Isolation and Cultivation of Naïve-like Human Pluripotent Stem Cells based on HERVH Expression. Nat Protoc. 2016; 11(2): 327-346.(Featured in Nature Protocols; Cover article)

5. Sabine Klawitter*, Nina V. Fuchs*, Kyle R. Upton*, Martin Muñoz-Lopez*, Ruchi Shukla, Jichang Wang, Marta Garcia-Canadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Sylvia Merkert, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Balázs Sarkadi, Johannes Löwer, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, Jose L. Garcia-Perez#, Geoffrey J. Faulkner#, Gerald G. Schumann#. Reprogramming triggers endogenous L1, Alu and SVA retrotransposition in human induced pluripotent stem cells. Nat Commun. 2016; 7: 10286.


6. Zsuzsanna Izsvák#, Jichang Wang, Manvendra Singh, Dixie L. Mager, Laurence D. Hurst. Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity? BioEssays. 2016; 38(1): 109-117. (Invited review)

7. Jichang Wang*, Gangcai Xie*, Manvedra Singh, Avazeh T. Ghanbarian, Tamás Raskó, Attila Szvetnik, Huiqiang Cai, Daniel Besser, Alessandro Prigione, Nina Fuchs, Gerald Schumann, Wei Chen, Matthew C. Lorincz, Zoltán Ivics, Laurence D. Hurst#, Zsuzsanna Izsvák#. Primate-specific endogenous retrovirus driven transcription defines naïve-like stem cells. Nature. 2014; 516(7531): 405-409.

8. Yongming Wang*, Jichang Wang*, Anatharam Devaraj, Manvendra Singh, Ana Jimenez Orgaz, Jia-Xuan Chen, Matthias Selbach, Zoltán Ivics#, Zsuzsanna Izsvák#. Suicidal autointegration of sleeping beauty and piggyback transposons in eukaryotic cells. PLoS Genet. 2014; 10(3): e1004103.

9. Wenli Zhang; Manish Solanki, Melanie Ebel, Chistina Rauschhuber, Nadine Müther, Jichang Wang, Chuanbo Sun, Zsuzsanna Izsvak, Anja Ehrhardt#. Hybrid adeno-associated viral vectors utilizing transposase-mediated somatic integration for stable transgene expression in human cells. PLoS ONE. 2013; 8(10): e76771.

10. Wenli Zhang, Martin Muck-Hausl, Jichang Wang, Chuanbo Sun, Maren Gebbing, Csaba Miskey, Zoltan Ivics, Zsuzsanna Izsvak and Anja Ehrhardt#. Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive Sleeping Beauty transposase for somatic integration. PLoS ONE. 2013; 8(10): e75344.

11. Ivana Grabundzija*, Jichang Wang*, Attila Sebe*, Zsuzsanna Erdei, Robert Kajdi, Anantharam Devaraj, Doris Steinemann, Károly Szuhai, Ulrike Stein, Tobias Cantz, Axel Schambach, Christopher Baum, Zsuzsanna Izsvák#, Balázs Sarkadi#, and Zoltán Ivics#. Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells. Nucleic Acids Res. 2013; 41(3): 1829-1847. 



12. Ruizhen Shi, Jichang Wang, Songhua Huang, Xiaojun Wang, Qingping Li#. Angiotensin II induces vascular endothelial growth factor synthesis in mesenchymal stem cells. Exp Cell Res. 2009; 315(1): 10-15.

专利、著作版权等

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