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王海河

领域:生物产业 学校:中山大学职称:教授

肿瘤转移过程中相关基因在肿瘤发生、转移和癌症干细胞分化形成过程中作用的分子信号传导机制,为癌症的有效诊断和治疗奠定理论和实践基础...

具体了解该专家信息,请致电:027-87555799 邮箱 haizhi@uipplus.com

教育背景

1990年-1997年先后在西北农业大学获得学士和硕士学位。2000年7月在福建农业大学获得博士学位

工作经历

2001年4月—2010年12月,曾先后在新加坡国立大学(NUS)、新加坡基因研究院(GIS)和新加坡分子与细胞研究院(IMCB)从事博士后和专职研究员工作,2011年1月回国加入中山大学中山医学院工作

项目课题经历

所负责承担的科研项目:
国家自然基金(批准号:81672704),2017-2020;项目负责人;58万元(直接经费);
广东省科技计划(批准号:2015B020211012),2015.10-2017.12;联合主持,100万元;
广州市科技计划(批准号:201607010223),2016-2018;项目负责人;20万元;
广东省自然基金国际合作项目(批准号:2014A050503030),2016.01-2018.12;项目负责人,50万元;
国家自然基金(批准号:81472730),2015-2018;项目负责人;72万元;
国家自然基金(批准号:31271481),2013-2016;项目负责人;80万元;
国家自然基金(批准号:81171947),2012-2015;项目负责人;60万元;
广东省教育厅科技创新项目(编号:2012KJCX0002),2013-2014;项目负责人;6万元。
中山大学百人计划启动基金,2011-2012;项目负责人;80万元。

论文、成果、著作等

学术论著与教材:
* 通讯作者

Shi H, Li H, Yuan R, Guan W, Zhang X, Zhang S, Zhang W, Tong F, Li L, Song Z, Wang C, Yang S and Wang H. PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation. Journal of Experimental & Clinical Cancer Research (2018) 37:187 IF=6.251

He K, Wu L, Ding Q, Haider F, Yu H, Wang H*, Xiang G*. Apatinib promotes apoptosis of pancreatic cancer cells through downregulation of hypoxia-inducible factor-1α and increased levels of reactive oxygen species. Oxidative Medicine and Cellular Longevity, 2019, https://doi.org/10.1155/2019/5152072. IF=4.936

Xu L, Zhang M, Li H, Guan W, Liu B, Liu F, Wang H, Li J, Yang S, Tong X* & Wang H* SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia.Leukemia & Lymphoma, 2017, DOI: 10.1080/10428194.2017.1344843

Tong F, Guo X, Shi H, Zhang M, Li L, Wang H*, Yang S*. Expression patterns of SH3BGR family members in zebrafish development. Development Genes and Evolution. 2016, 226(4),287-295.

Liu B, Zhang M, Fang T, Yang S and Wang H*. Expression patterns and physiological roles of SH3BGR protein family as adaptor proteins. Integr Cancer Sci Therap, 2016, 3(2): 410-413. Invited review.

Zhang W#, Shi H#, Zhang M, Liu B, Mao S, Li L, Tong F, Liu G, Yang S, and Wang H*. Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation. International Journal of Biochemistry and Cell Biology, 2016,73,127-136. http://dx.doi.org/10.1016/j.biocel. 2016.02.009. IF=4.056.


Li L, Shi H, Zhang M, Guo X, Tong Fang, Zhang W, Zhou J, Wang H*, and Yang S*. Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish. International Journal of Oncology,2016, 48(4)1541-1552. IF=3.03.

Wang H*, Liu B, Al-aidaroos AQ, Li L, Shi H, Guo K, Li J, Tan JP, Loo JM, Liu B, Shi H, and Zeng Q. Dual-faced SH3BGRL: oncogenic in mice, tumor suppressive in humans. Oncogene,2016, 35 (25): 3303-3313, online publication, doi: 10.1038/onc.2015.391. IF=8.456)


Dong Q, Ding X, Chang B, Wang H, Wang A. PRL-3 promotes migration and invasion and is associated with poor prognosis in salivary adenoid cystic carcinoma. J Oral Pathol Med. 2015 Jun 3. doi: 10.1111/jop.12331. [Epub ahead of print]

Chen Y, Pei H, Chang Y, Chen M, Wang H, Xie H and Yao S*. The impact of endometrioma and laparoscopic cystectomy on ovarian reserve and the exploration of related factors assessed by serum anti-Mullerian hormone: a prospective cohort study. Journal of Ovarian Research 2014, 7:108

Qu S, Liu B,Guo X, Shi H, Zhou M, Li L, Yang S, Tong X* and Wang HH*.2014. Independent oncogenic and therapeutic significance of phosphatase PRL-3 in FLT3-ITD negative acute myeloid leukemia. Cancer, 120:2130-2141 (IF=5.201)

Hao Liu, Abdul Qader Al-aidaroos, Haihe Wang, Ke Guo, Jie Li, Hua Fei Zhang and Qi Zeng. 2013.PRL-3 suppresses c-Fos and integrin alpha2 expression in ovarian cancer cells. BMC Cancer. 13:80 doi:10.1186/1471-2407-13-80.

Wang H.H., Vardy Leah , Tan Cheng Peow, Loo Jia Min, Guo Ke, Li Jie, Lim Seng Gee, Zhou Jianbiao, Chng Wee Joo, Ng Siok Bian, Li Hui Xiang and Zeng Qi. 2010. PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase. Cancer Cell, 18:52-62.

Guo Ke*, Li Jie*, Tang Jing Ping*, Tan Bobby, Wang H. H., Zeng Qi. 2008. Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice.Cancer Biology& Therapy, 7(5):750-757 * Equal contribution.

Wang H.H. Quah Yi Ling, Samatha, Dong Jing Ming, Manser E., Tang Jing Ping, Zeng Qi. 2007. PRL-3 downregulates PTEN expression and signals through PI3K to promote epithelial-mensenchymal transition. Cancer Res. 67 (7): 2922-2926.

Guo K., Li, J., Wang H.H., Osato M., Tang J.P., Quah S.Y., Gan B.Q., and Zeng Q. 2006. PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. Cancer Res. 66: 9625-9635.

Cao S. S., Wang H.H., Luhur A., and Wong S.M. 2005.Yeast expression and characterization of SARS-CoV N protein. Journal of Virological Methods, 130: 83-88.

Wang H. H., H. H. Yu, and S. M. Wong. 2004. Mutation of Phe 50 to Ser 50 in the 126/183 Kilodalton proteins of Odontoglossum ringspot virusabolishes virus replication but can be restored by reversion. Journal of General Virology, 85: 2447-2457.

Wang H. H. and S. M. Wong. 2004. Significance of 3’-terminal region in minus-strand synthesis of Hibiscus chlorotic ringspot virus. Journal of General Virology, 85: 1763-1776.

专利、著作版权等

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