教育背景
2010-2015:博士研究生,药理学专业,中山大学
2006-2010:本科生,生物技术与应用专业,中山大学
工作经历
2018-至今,副教授,中山医学院,中山大学
2015-2018:博士后,中山大学
项目课题经历
论文、成果、著作等
学术论著
1. Lin Y, Zhang H, Liang J, Li K, Zhu W, Fu L, Wang F, Zheng X, Shi H, Wu S, Xiao X, Chen L, Tang L, Yan M, Yang X, Tan Y, Qiu P, Huang Y, Yin W, Su X, Hu H, Hu J, Yan G. Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers. Proc Natl Acad Sci U S A. 2014, 111:E4504-4512.
2. Zhang H, Li K, Lin Y (co-first author), Xing F, Xiao X, Cai J, Zhu W, Liang J, Tan Y, Fu L, Wang F, Yin W, Lu B, Qiu P, Su X, Gong S, Bai X, Hu J, Yan G. Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma. Sci Transl Med. 2017, 9:eaam7996.(Nature Reviews Gastroenterology & Hepatology发表对本文的科学评述文章)
3. Cai J, Lin Y (co-first author), Zhang H, Liang J, Tan Y, Cavenee WK, Yan G. Selective replication of oncolytic virus M1 results in a bystander killing effect that is potentiated by Smac mimetics. Proc Natl Acad Sci U S A. 2017, 114:6812-6817.
4. Wu S, Lin Y (co-first author), Xu D, Chen J, Shu M, Zhou Y, Zhu W, Su X, Zhou Y, Qiu P, Yan G. MiR-135a functions as a selective killer of malignant glioma. Oncogene, 2012, 31:3866-3874.
5. Zhang H, Lin Y (co-first author), Li K, Liang J, Xiao X, Cai J, Tan Y, Xing F, Mai J, Li Y, Chen W, Sheng L, Gu J, Zhu W, Yin W, Qiu P, Su X, Lu B, Tian X, Liu J, Lu W, Dou Y, Huang Y, Hu B, Kang Z, Gao G, Mao Z, Cheng SY, Lu L, Bai XT, Gong S, Yan G, Hu J. Naturally existing oncolytic virus M1 is nonpathogenic for the nonhuman primates after multiple rounds of repeated intravenous injections. Hum Gene Ther. 2016, 27:700-711.
6. Tan Y, Lin Y (co-first author), Li K, Xiao X, Liang J, Cai J, Guo L, Li C, Zhu W, Xing F, Mai J, Gu J, Tan X, Yin W, Lu B, Qiu P, Su X, Gao M, Hu J, He S, Lu L, Gong S, Yan G, Zhang H. Selective antagonism of Bcl-xL potentiates M1 oncolysis by enhancing mitochondrial apoptosis. Hum Gene Ther. 2018, 29(8):950-961.
7. Liang J, Li K, Xiao X, Zhu W, Zheng X, Hu J, Zhang H, Cai J, Tan Y, Li C, Yu Y, Hu C, Liu Y, Qiu P, Su X, He S, Guo L, Liu X, Lin Y (co-corresponding author), Yan G. Inhibition of the Mevalonate pathway enhances cancer cell oncolysis mediated by M1 Virus. Nat Commun, 2018, 9(1):1524.
8. Xiao X, Liang J, Huang C, Li K, Xing F, Zhu W, Lin Z, Xu W, Wu G, Zhang J, Lin X, Tan Y, Cai J, Hu J, Chen X, Huang Y, Qin Z, Qiu P, Su X, Chen L, Lin Y (co-corresponding author), Zhang H, Yan G. DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage. Nat Commun, 2018, 9(1):4342.
9. Li K, Hu C, Xing F, Gao M, Liang J, Xiao X, Cai J, Tan Y, Hu J, Zhu W, Yin W, Li Y, Chen W, Lu B, Mai J, Qiu P, Su X, Yan G, Zhang H, and Lin Y (corresponding author). Deficiency of the IRE1α-autophagy axis enhances the antitumor effects of the oncolytic virus M1. J Virol, 2018, 92(6). pii: e01331-17.
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