教育背景
2009年中科院上海生物化学与细胞生物学研究所获得细胞生物学博士学位
工作经历
随后在斯柯里普斯研究所(The Scripps Research Institute)以及美国加州大学旧金山分校戴维•格拉斯通研究所(J. David Gladstone Institutes)从事博士后研究工作
项目课题经历
论文、成果、著作等
在Nature、Nature Immunology等国际顶级期刊上发表论文14篇,总引用过1000次 代表性论文:
Tao Xu*, Kelly M. Stewart*, Xiaohu Wang*, Kai Liu, Min Xie, Jae Kyu Ryu, Ke Li, Tianhua Ma, Haixia Wang, Lu Ni, Saiyong Zhu, Nan Cao, Dongwei Zhu, Yu Zhang, Katerina Akassoglou, Chen Dong#, Edward M. Driggers# and Sheng Ding#. Metabolic control of TH17/iTreg balance through an epigenetic mechanism. Nature548, 228-233 (2017). Preview at Cell Metabolism 26, 588-590. (*Co-first author, # corresponding author)
Nan Cao, Yu Huang, Jiashun Zheng, C Ian Spencer, Yu Zhang, Ji-Dong Fu, Baoming Nie, Min Xie, Mingliang Zhang, Haixia Wang, Tianhua Ma, Tao Xu, Guilai Shi, Deepak Srivastava, Sheng Ding. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science 352 (6290), 1216-1220 (2016)
Yu Zhang, Nan Cao, Yu Huang, C Ian Spencer, Ji-dong Fu, Chen Yu, Kai Liu, Baoming Nie, Tao Xu, Ke Li, Shaohua Xu, Benoit G Bruneau, Deepak Srivastava, Sheng Ding. Expandable cardiovascular progenitor cells reprogrammed from fibroblasts. Cell Stem Cell 18 (3), 368-381 (2016).
Saiyong Zhu, Holger A. Russ, Xiaojing Wang, Mingliang Zhang, Tianhua Ma, Tao Xu, Shibing Tang, Matthias Hebrok & Sheng Ding. Human pancreatic beta-like cells converted from fibroblasts. Nature Communication 7 (2016).
Tianhua Ma, Jun Li, Yue Xu, Chen Yu, Tao Xu, Haixia Wang, Kai Liu, Nan Cao, Bao-ming Nie, Saiyong Zhu, Shaohua Xu, Ke Li, Wan-Guo Wei, Kun-Liang Guan and Sheng Ding. Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming. Nature Cell Biology 17, 1379-1387 (2015)
Ke Li, Saiyong Zhu, Holger A. Russ, Shaohua Xu, Tao Xu, Yu Zhang, Matthias Hebrok, and Sheng Ding. Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell 14 (2), 228-236 (2014).
Haixia Wang, Nan Cao, C. Ian Spencer, Baoming Nie, Tao Xu, Yu Zhang, Xiaojing Wang, Deepak Srivastava, and Sheng Ding. Small Molecules Enable Cardiac Reprogramming of Mouse Fibroblasts with a Single Factor, Oct4. Cell Reports 2, 951-960 (2014).
Tao Xu*, Mingliang Zhang*, Timothy Laurent, Min Xie, and Sheng Ding. Chemical approaches for modulating lineages-restricted stem cells and progenitors. Stem Cells Transl Med. 2013 May;2(5):355-61.(Invited Review) (*Co-first author)
Tao Xu*, Xiaohu Wang*, Bo Zhong, Roza I. Nurieva, Sheng Ding, and Chen Dong. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORүt protein. J Biol Chem. 2011 Jul 1; 286(26):22707-10. Epub 2011 May 12. (Highlighted in SciBX, a Nature sister journal; and in Nature Review Immunology). (*Co-first author)
Tao Xu, Lei Zhang, Zhen H. Geng, Hai-Bo Wang, Jin-Tao Wang, Ming Chen, Jian-Guo Geng. P-selectin Cross-links PSGL-1 and enhances Neutrophil Adhesion to Fibrinogen and ICAM-1 in a Src Kinase-dependent, but GPCR-independent Mechanism. Cell Adhesion & Migration, 2007, 1(3). 1-9
Hai-Bo Wang*, Jin-Tao Wang*, Lei Zhang*, Zhen H Geng*, Wei-Li Xu*, Tao Xu*, Yuqing Huo, Xueliang Zhu, Edward F Plow, Ming Chen & Jian-Guo Geng. P-selectin primes leukocyte integrin activation during inflammation. Nature Immunology 2007, 8(8):882-92. (*Co-first author)
专利、著作版权等
Tao Xu and Sheng Ding. Methods of Treating Diseases by Metabolic control of T-Cell differentiation, PCT/US2017/013252
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