本科毕业于中山医学院临床医学专业 在中山医科大学中山三院血液内科获得医学硕士学位，在美国纽约州立大学上州医学中心获理学博士学位

1997年被聘为费城托马斯-杰佛逊大学医学院传染内科并人类病毒学研究中心助理教授， 2008年升为正教授（终身）。2005年起被任命为杰佛逊大学人类病毒学和生物防护研究所副所长。

主持研究生和本科生《生物医学论文导读》的讨论课教学。近年作为项目负责人先后主持国家艾滋病和病毒性肝炎等传染病防治重大专项“十二五”及“十三五”各一项、一项国家自然基金委重大项目、一项国家自然基金委重点项目、一项中国NSFC-美国NIH合作项目。1，重大人类致病病毒特异性药物的研发与免疫细胞的再生工程，广东省引进创新科研团队项目8000万元 项目负责人。已结题（结题考核优秀）

2，抗艾滋病毒特异性免疫功能的重建，“十二五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项（2013ZX10001004，2013.01-2015.12）1871万元 项目负责人，已结题

3，埃博拉病毒与宿主因子相互作用研究,国家自然科学基金重大计划（81590765, 2015.07-2017.12）395.04万，项目负责人，已结题

4，非编码RNA在HIV-1潜伏感染的建立和维持过程中分子机理研究，国家自然科学基金-NSFC-NIH中美联合项目（81561128007, 2016.01-2018.12. 299.96万，项目负责人，已结题

5，关于HIV-1病毒储存库形成的表观遗传学机制及其清除手段的机理研究，国家自然科学基金重点项目（81730060，2018.01-2022.12）295万元 项目负责人。

6，艾滋病精准诊治标志物的鉴定，“十三五” 艾滋病和病毒性肝炎等重大传染病防治科技重大专项（2018ZX10302103，2018.01-2020.12）1843.15万元 项目负责人

作为第一和通讯作者，已经在诸多高影响的杂志，如《Nature》、《New England Journal of Medicine》、《Nature Medicine》、《PNAS》、《Nature Communications》、《Nuclear Acid Research》、《BMC Medicine》、《eLife》、《Molecular Therapy》、《Journal of Virology》、《Journal of Immunology》、《European Journal of Medicinal Chemistry》、《Journal of Biological Chemistry》上发表论文。发表SCI论文100篇以上，论文总引次数在5000以上

回国前代表性工作：

1 Zhang H, Dornadula G, Beumont M, Livornese L Jr, Van Uitert B, Henning K, Pomerantz RJ. Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy. New England Journal of Medicine. 1998. 339: 1803-1839

2 Zhang H*, Pomerantz RJ, Dornadula G, Sun Y. Human immunodeficiency virus type 1 Vif protein is an integral component of an mRNP complex of viral RNA and could be involved in the viral RNA folding and packaging process. Journal of Virology. 2000. 74: 8252-8261.

3 Dornadula G, Yang SC, Pomerantz RJ, Zhang H*. Partial rescue of the Vif-negative phenotype of mutant HIV-1 viruses from non-permissive cells by intravirion reverse transcription. Journal of Virology. 2000. 74:2594-2602.

4 Zhang H*, Yang B, Pomerantz RJ, Zhang C, Arunachalam SC, Gao L. The cytidine deaminase CEM15 induces hypermutation in newly-synthesized HIV-1 DNA. Nature. 2003. 424: 94-98.

5 Chen K, Huang J, Zhang C, Huang S, Nunnari G, Wang FX, Tong X, Gao, L, Nikisher K, Zhang H*. Alpha interferon potently enhances the anti-HIV-1 activity of APOBEC3G in resting primary CD4 T-cells. Journal of Virology. 2006. 80:7645-7657

6 Huang JL, Wang FX, Argyris E, Chen KY, Liang ZH, Tian H, Huang WL, Squires K, Verlinghieri G, and Zhang H*: Cellular microRNAs contribute to HIV-1 latency in resting CD4+ T-lymphocytes. Nature Medicine. 2007. 13: 1241-1247



最近五年代表性工作:

7 He X, Chen X, Zhang X, Duan X, Pan T, Hu Q, Zhang Y, Zhong F, Liu J, Zhang H, Luo J, Wu K, Peng G, Luo H, Zhang L, Li X*, and Zhang H*. An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes. Nucleic Acids Research. 2015. 43:3712-25.

8 Zhong, F., N. Zhou, K. Wu, Y. Guo, W. Tan, H. Zhang, X. Zhang, G. Geng, T. Pan, H. Luo, Y. Zhang, Z. Xu, J. Liu, B. Liu, W. Gao, C. Liu, L. Ren, J. Li, J. Zhou, and Zhang H*. A SnoRNA-derived piRNA interacts with human interleukin-4 pre-mRNA and induces its decay in nuclear exosomes. Nucleic Acids Research. 2015. 43:10474-91

9 Liu C, Ma X, Liu B, Chen C, Zhang H*. HIV-1 functional cure: will the dream come true? (invited review). BMC Medicine. 2015.13:284-295.

10 Geng G, Liu B, Chen C, Wu K, Liu J, Zhang Y, Pan T, Li J, Yin Y, Zhang J, Huang F, Yu F, Chen J, Ma X, Zhou J, Kuang E, Liu C, Cai W, and Zhang H*. Development of an Attenuated Tat Protein as a Highly-effective Agent to Specifically Activate HIV-1 Latency. Molecular Therapy. 2016. 24:1528-37.

11 Liu B, Zou F, Lu LJ, Chen CC, He DL, Zhang X, Tang XP, Liu C, Li LH*, and Zhang H*. Chimeric antigen receptor-T Cells guided by the single-chain Fv of a broadly neutralizing antibody specifically and effectively eradicate the reactivated virus-latently-infected CD4+ T-lymphocytes isolated from HIV-1-infected individuals receiving suppressive cART. Journal of Virology. 2016. 90:9712-9724

12 Li J, Chen C, Ma X, Geng GN, Liu BF, Zhang YJ, Zhang SY, Zhong FD, Liu C, Yin Y, Cai WP, and Zhang H*. Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing Tat protein degradation. Nature Communications. 2016.7:11730. doi: 10.1038/ncomms11730 .

13 Zhang J, Huang F, Tan L, Bai C, Chen B, Liu J, Liang J, Liu C, Zhang S, Lu G, Chen Y, and Zhang H*. Host Protein Moloney Leukemia Virus 10 (MOV10) Acts as a Restriction Factor of Influenza A Virus by Inhibiting the Nuclear Import of the Viral Nucleoprotein. Journal of Virology. 2016. 90: 3966-80

14 Zhang X, He X, Liu C, Liu J, Hu Q, Pan T, Duan X, Liu B, Zhang Y, Chen J, Ma X, Zhang X, Luo H, and Zhang H*. IL-4 Inhibits the Biogenesis of an Epigenetically Suppressive PIWI-Interacting RNA To Upregulate CD1a Molecules on Monocytes/Dendritic Cells. Journal of Immunology. 2016. 196:1591-603.

15 Zhang YW, Liu WW, Chen YS, Liu J, Wu K, Su LS, Zhang WY, Jiang YW, Zhang X, Zhang YJ, Liu C, Tao L, Liu BF*, and Zhang H* A Cellular MicroRNA Facilitates Regulatory T Lymphocyte Development by Targeting the FOXP3 Promoter TATA-Box Motif. Journal of Immunology. 2018; 200:1053-1063.

16 Pan T, Peng ZL, Tan LK, Zou F, Zhou N, Liu BF, Liang LT, Chen CC, Liu J, Wu LY, Liu GY, Peng ZL, Liu WW, Ma XC, Zhang JS, Zhu X, Liu T, Li MF, Huang X, Tao L, Zhang YW* and Zhang H*. Nonsteroidal Anti-inflammatory Drugs Potently Inhibit the Replication of Zika Viruses by Inducing the Degradation of AXL. Journal of Virology. 2018. 92 (20). e01018-18

17 Zhang X, Ma X, Jing S, Zhang H*, Zhang Y*. Non-coding RNAs and retroviruses (Invited review). Retrovirology. 2018.15:20. doi: 10.1186/s12977-018-0403-8.

18 Pan T, Ding Y, Wu L, Liang L, He X, Li Q, Bai C*, and Zhang H*. Design and synthesis of aminothiazole based Hepatitis B Virus (HBV) capsid inhibitors. European Journal of Medicinal Chemistry. 2019. 166: 480-501:

19 Ma XC, Yang T, Luo YW, Wu LY, Jiang YW, Song Z, Pan T, Liu BF, Liu G, Liu J, Yu F, He Z, Zhang W, Yang J, Liang L, Guan Y, Zhang X, Li L, Cai W, Tang X, Gao S, Deng K, and Zhang H*. TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb. eLife. 2019; 8. pii: e42426. doi: 10.7554/eLife.42426.

20 Luo YW, Liu Y, Wu LY, Ma XC, Liu Q, Huang F, Zhang X, Zhang YW, Zhang JS, Luo HH， Yang Y, Lu G, Tang XP, Li LH, Zeng YX, Pan T*, and Zhang H*. CUL7 E3 Ubiquitin Ligase Mediates the Degradation of Activation-induced Cytidine Deaminase (AID) and Regulates the Immunoglobulin Class Switch Recombination in B-Lymphocytes. Journal of Immunology. 2019; 203:269-281.

21 Liu B, Zhang W, Zhang H*. Development of CAR-T cells for long-term eradication and surveillance of HIV-1 reservoir (Invited review). Current Opinion in Virology. 2019. 38: 21-30.

回国后的成果已经申请五十多项国内和国际专利，已获授权三十多项