2000.9-2004.07 中国科学技术大学 生命科学学院 理学学士

2004.9-2009.12 中国科学技术大学 细胞与分子生物学系 理学博士

2010.4-2016.3 美国加州大学旧金山分校 生物化学系 博士后 2016.4-2017.1 美国加州大学旧金山分校 生物化学系 Specialist 2017.2-至今 中南大学生命科学学院/中南大学湘雅医院 教授

1. 利用高时空分辨率实时成像解析异染色质形成等早期胚胎发育过程中的关键事件。基于本团队先前开发的TALE-light技术，动态解析发育过程中不同亚核细胞器在对应的DNA核心序列上的组装过程和分子机制；开发用于研究早期胚胎发育其他关键事件的新型光学探针。

2. 利用基因组学和高通量筛选研究DNA重复序列及转座元件在人类重大疾病中的功能。通过高通量CRISPR筛选和基因组学等方法，鉴定出参与癌症等人类重大疾病发生发展的重要DNA重复序列和转座元件，并以此为基础开发新的疾病干预手段。

1. Yuan K, Seller CA, Shermoen AW, O’Farrell PH. Timing the Drosophila Mid-Blastula Transition: a cell cycle-centered view. Trends Genet. 2016; 32(8):496-507. (Review)

2. Yuan K#, O’Farrell PH#. TALE-light imaging reveals maternally-guided, H3K9me2/3-independent emergence of functional heterochromatin in Drosophila embryos. Genes Dev. 2016; 30:579-593.

3. Shao H., Huang Y.#, Zhang L., Yuan K#, Chu Y., Dou Z, Jin C., Garcia-Barrio M, Liu X#, Yao X. Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation. Sci Rep. 2015; 5:12204.

4. Yuan K, O’Farrell PH. Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition. Curr Biol. 2015; 25(6):811-816.

5. Yuan K, Shermoen AW, O’Farrell PH. Illuminating DNA replication during Drosophila development using TALE-lights. Curr Biol. 2014; 24(4):R144-R145.

6. Yuan K, Farrell JA, O’Farrell PH. Different cyclin-types collaborate to reverse the S phase checkpoint and permit prompt mitosis. J Cell Biol. 2012; 198(6):973-980.

7. Yuan K, Huang Y, Yao X. Illumination of mitotic orchestra during cell division: A polo view. Cell Signal. 2011; 23(1):1-5. (Review)

8. Yuan K, Li N, Jiang K, Zhu T, Huo Y, Wang C, Lu J, Shaw AP, Thomas K, Zhang J, Mann D, Liao J, Jin C, Yao X. PinX1 is a Novel Microtubule-binding Protein Essential for Accurate Chromosome Segregation. J Biol Chem. 2009; 284(34):23072-23082.

9. Yuan K*, Li N*, Huo Y, Yan F, Yang Y, Ward T, Jin C, Yao X. Recruitment of separase to mitotic chromosomes is regulated by Aurora B. Cell Cycle. 2009; 8(9):1433-1443.

10. Yuan K*, Hu H*, Guo Z, Fu G, Shaw AP, Hu R, Yao X. Phospho-regulation of HsCDC14A by polo-like kinase 1 is essential for mitotic progression. J Biol Chem. 2007; 282(37):27414-27423.

# co-corresponding authors *co-first authors