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李家大

领域:生物产业 学校:中南大学职称:教授

在生物化学、分子生物学、细胞以及模式动物水平来研究疾病致病基因的功能,探讨疾病的病理机制,建立疾病的动物模型以及筛选新型药物。...

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教育背景

1989.9-1993.6,兰州大学生物系生物化学专业,理学学士

1996.9-2001.6,中国科学院上海生物化学与细胞生物学研究所,理学博士

工作经历

1993.7-1996.8,南华大学医学院(衡阳医学院)生物化学教研室,助教 2001.11-2009.6,美国加州大学尔湾分校,博士后 2009.7-,中南大学生命科学学院,教授

项目课题经历

生物节律与睡眠的神经生物学基础及其与疾病的关系2. 孤独症小鼠模型的建立与表型分析3. GnRH缺陷疾病的致病机制

论文、成果、著作等

1. Li X, Shi L, Zhang K, Wei W, Liu Q, Mao F, Li J, Cai W, Chen H, Teng H*, Li J*, Sun Z*, CirGRDB: a database for the genome-wide deciphering circadian genes and regulators. Nucleic Acids Res. 2018 Jan 4;46(D1):D64-D70. doi: 10.1093/nar/gkx944. 文章链接




2. Pan Y, Zhang L, Liu Q, Li Y, Guo H, Peng Y, Peng H, Tang B, Hu Z, Zhao J, Xia K*, Li JD*. Insertion of a knockout-first cassette in Ampd1 gene leads to neonatal death by disruption of neighboring genes expression. Sci Rep. 2016 Oct 24;6:35970. doi: 10.1038/srep35970. 文章链接




3. Zhang S, Zhang J, Deng Z, Liu H, Mao W, Jiang F, Xia Z, Li JD*. Circadian clock components RORα and Bmal1 mediate the anti-proliferative effect of MLN4924 in osteosarcoma cells. Oncotarget. 2016 Sep 1. doi: 10.18632/oncotarget.11807. 文章链接




4. Hu H, Liu J, Liao X, Zhang S, Li H, Lu R, Li X, Lin W, Liu M, Xia Z, Qing G, Li JD*. Genetic and functional analysis of a Li Fraumeni syndrome family in China. Sci Rep. 2016 Jan 28;6:20221. doi: 10.1038/srep20221. 文章链接




5. Chen DN, Ma YT, Liu H, Zhou QY, Li JD*. Functional Rescue of Kallmann Syndrome-associated Prokineticin Receptor 2 (PKR2) Mutants Deficient in Trafficking. J Biol Chem. 2014 May 30;289(22):15518-15526. 文章链接




6. Zhang H, Chen H, Luo H, An J, Sun L, Mei L, He C, Jiang L, Jiang W, Xia K, Li JD*, Feng Y*. Functional analysis of Waardenburg syndrome-associated PAX3 and SOX10 mutations: report of a dominant-negative SOX10 mutation in Waardenburg syndrome type II, Hum Genet. 2012; 131(3): 491-503. doi: 10.1007/s00439-011-1098-2. 文章链接




7. Peng Z, Tang Y, Luo H, Jiang F, Yang J, Sun L, Li JD*. Disease-causing Mutation in PKR2 Receptor Reveals a Critical Role of Positive Charges in the Second Intracellular Loop for G-protein Coupling and Receptor Trafficking. J Biol Chem. 2011; 286(19):16615-22. doi: 10.1074/jbc.M111.223784. 文章链接




8. Li JD, Hu WP, Zhou QY*. Disruption of the circadian output molecule prokineticin 2 results in anxiolytic and antidepressant-like effects in mice. Neuropsychopharmacology. 2009; 34(2): 367-73. doi: 10.1038/npp.2008.61. 文章链接




9. Li JD, Hu WP, Boehmer L, Cheng MY, Lee AG, Jilek A, Siegel JM, Zhou QY*. Attenuated Circadian Rhythms in Mice Lacking the Prokineticin 2 Gene. J Neurosci. 2006, 26(45):11615-23. 文章链接




10. Ng KL, Li JD, Cheng MY, Leslie FM, Lee AG, Zhou QY. Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling. Science, 2005, 308 (5730):1923-7. 文章链接

专利、著作版权等

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