生物化学与分子生物学 博士（2004年）

生物化学与分子生物学 副教授 中南大学生命科学学院生物化学与分子生物学系副主任、党支部书记

1、人类恶性肿瘤基因治疗研究：研究主要针对神经系统肿瘤、乳腺肿瘤、皮肤肿瘤等疾病，采用主要技术手段包括细胞培养、基因芯片、基因转移技术、蛋白质分析等；2、DNA损伤与修复基础研究：探索调控自杀基因治疗系统的DNA损伤修复及对顺铂耐药作用改变的分子生物学基础，鉴定其易感基因，为阐明肿瘤发病机制、提供更好的肿瘤治疗效果提供科学依据。3、基因结构与功能研究：主要研究神经母细胞瘤细胞等在缺氧环境中TLX与肿瘤发生、增殖过程的关系及在TGF-ß/Smad分子调控信号机制。参与神经细胞老化与阿尔茨海默病脑内形成机制的研究，雾霾DNA损伤及药物干预修复的研究，病毒性脑炎的分子诊断等研究，为认识疾病的分子病理机制奠定重要基础。

1. Zeng ZJ, Xiang SG, Xue WW, Li HD, Ma N, Ren ZJ, Xu ZJ, Jiao CH, Wang CY, Hu WX. The cell death and DNA damages caused by the Tet-On regulating HSV-tk/GCV suicide gene system in MCF-7 cells Biomed Pharmacother. 2014 Jul 28. pii:S0753-3322(14) 094-098.

2. Chavali PL, Saini RK, Zhai Q, Vizlin-Hodzic D, Venkatabalasubramanian S, Hayashi A, Johansson E, Zeng ZJ, Mohlin S, Påhlman S, Hansford L, Kaplan DR, Funa K. TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival. Cell Death Dis. 2014 Oct 30;5:e1502. doi: 10.1038/cddis.2014.449.

3. Chavali PL, Saini RK, Zhai Q, Vizlin-Hodzic D, Venkatabalasubramanian S, Hayashi A, Johansson E, Zeng ZJ, Mohlin S, Påhlman S, Hansford L, Kaplan DR, Funa K. TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival. Cell Death Dis. 2014 Oct 30;5:e1502. doi: 10.1038/cddis.2014.449.

4. Zhao-jun Zeng, Erik Johansson, Amiko Hayashi, Pavithra L. Chavali, Nina Akrap, Takeshi Yoshida，Kimitoshi Kohno, Hiroto Izumi3 and Keiko Funa. TLX controls angiogenesis through interaction with the von Hippel-Lindau protein. Biology Open. June 15, 2012，1 (6) :527-535.

5. Elmi M, Matsumoto Y, Zeng ZJ, Lakshminarasimhan P, Yang W, Uemura A,Nishikawa SI, Moshiri A, Tajima N, Agren H, Funa K*. TLX activates MASH1 for induction of neuronal lineage commitment of adult hippocampal neuroprogenitors. Molecular Cell Neuroscience. 2010 Oct;45(2):121-31.

6. Li ZB, Zeng ZJ, Chen Q, Luo SQ, Hu WX. Recombinant AAV-mediated HSVtk gene transfer with direct intratumoral injections and Tet-On regulation for implanted human breast cancer. BMC Cancer. 2006 Mar 16;6:66.

7. Zeng ZJ, Li ZB, Luo SQ, Hu WX. Retrovirus-mediated tk gene therapy of implanted human breast cancer in nude mice under the regulation of Tet-On. Cancer Gene Ther. 2006 Mar;13(3):290-297.

8. Hu WX, Zeng ZJ, Luo SQ, Chen Q. Suicide gene therapy of human breast cancer in SCID mice model by the regulation of Tet-On. Chin Med J (Engl). 2004 Mar;11