1989年获湖南医科大学医学遗传学硕士学位；

1995年获美国加州大学分子病理学专业博士（Ph.D）；

美国哈佛大学神经病学博士后。

1.Zou Y, He W, Wang K, Han H, Xiao T, Chen X, Zhou B, Tan J, Xia K, Tang B, Chen C, Shen L, Yan R, Zhang Z. (2018) Identification of rare RTN3 variants in Alzheimer's disease in Han Chinese. Hum Genet. Feb;137(2):141-150.

2.Park G, Tan J, Garcia G, Kang Y, Salvesen G, Zhang Z. Regulation of Histone Acetylation by Autophagy in Parkinson Disease. J Biol Chem. 2016 Feb 12;291(7):3531-40. doi: 10.1074/jbc.M115.675488.

3.Zhang T, Xue L, Li L, Tang C, Wan Z, Wang R, Tan J, Tan Y, Han H, Tian R, Billiar TR, Tao WA, Zhang Z. BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy. J Biol Chem. 2016 Oct 7;291(41):21616-21629.

4.Zhang L, Deng J, Pan Q, Zhan Y, Fan JB, Zhang K, Zhang Z. Targeted methylation sequencing reveals dysregulated Wnt signaling in Parkinson disease. J Genet Genomics. 2016 Oct 20;43(10):587-592. doi: 10.1016/j.jgg.2016.05.002.

5.Tang C, Chen X, Chi J, Yang D, Liu S, Liu M, Pan Q, Fan J, Wang D, Zhang Z. (2015). Pathogenic Cx31 is un/misfolded to cause skin abnormality via a Fos/JunB-mediated mechanism. Hum Mol Genet. 24(21):6054-65.

6.Park G, Tan J, Garcia G, Kang Y, Salvesen G, Zhang Z. (2015). Regulation of Histone Acetylation by Autophagy in Parkinson Disease. J Biol Chem. [Epub ahead of print]

7.Deng, M., He, W., Tan, Y., Han, H., Hu, X., Xia, K., Zhang, Z*., and Yan, R*..(2013). Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β-site amyloid precursor protein cleaving enzyme 1. J Biol Chem, Sep 4. [Epub ahead of print].

8.Choo, Y.S., Vogler, G., Wang, D., Iliuk, A., Kalvakuri, S., Tao, A.W., and Zhang, Z.. (2012). Regulation of parkin and PINK1 by neddylation. Hum Mol Genet, 21, 2514-2523.

9.Tan, J., Zhang, T., Jiang, L., Chi, J., Hu, D., Pan, Q., Wang, D., and Zhang, Z.. (2011). Regulation of intracellular manganese hemeostasis by kufor-rakeb syndrome associated ATP13A2. J Biol Chem. 286, 29654-29662.

10.Xiong, H., Wang, D.L., Chen, L., Choo, Y.S., Ma, H., Tang, C.Y., Xia, X., Jiang, W., Ronai, Z., Zhuang, X., Zhang, Z.. (2009). Parkin, PINK1, and DJ-1 form a novel E3 ligase complex to promote unfolded protein degradation. J. Clin Invest, 119, 650-660. PMCID: PMC2648688.

11.Wang, D.L., Qian, L., Xiong, H., Liu, J., Neckameyer, W.S., Oldham, S., Xia, K., Wang, J.Z., Bodmer, R., and Zhang, Z.(2006). Antioxidants protect PINK1-dependent dopaminergic neuorons in Drosophila. Proc Natl Acad Sci U S A, 103, 13520-13525. PMCID: PMC1569195.

12.Tang, B., Xiong, H., Sun, P., Zhang, Y., Wang, D.L., Hu, Z., Zhu, Z., Ma, H., Pan, Q., Xia, J.H., Xia, K., and Zhang Z. (2006). Association of PINK1 and DJ-1 confers digenic inheritance of early onset Parkinson's disease. Hum Mol Genet.15, 1816-1825.

13.Wang, R., Zhang, Y-W, Zhang, X., Liu, R., Zhang, X., Hong, S.H., Xia, K., Xia, J., Zhang, Z.*, and Xu, H.* (2006) Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J. 20,1275-1277.

14.Wang, R., Zhang, R., Sun, P., Liu, R., Xia, K., Xia J., Xu, H. and Zhang, Z. (2006). Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB. Mol Cell Biol. 26,1347-1354. PMCID: PMC1367199.

15.Liu, C., Li, Y., Semenov, M., Han, C., Baeg, G.H., Tan, Y., Zhang, Z., Lin, X., He, X. (2002). Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108, 837-847.

16.Zhang, Z., Nadeau, P.M., Song, W.H., Donoviel, D., Yuan, M., Bernstein, A., and Yankner, B.A. (2000). Presenilins are required for g-secretase cleavage of ß-APP and transmembrane cleavage of Notch-1. Nat Cell Biol 2, 463-65.

17.Zhang, Z., Nadeau, P.M., Song, W.H., Donoviel, D., Yuan, M., Bernstein, A., and Yankner, B.A. (2000). Presenilins are required for g-secretase cleavage of ß-APP and transmembrane cleavage of Notch-1. Nat Cell Biol 2: 463-65.

18.Zhang, Z., Hartmann, H., Do, V.M., Abramowski, D., Sturchler-Pierrat, C., Staufenbiel, M., Sommer, B., van de Wetering, M., Clevers, H., Saftig, P., De Strooper, B., He, X., and Yankner, B.A. (1998). Destabilization of ß-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395: 698-702.

19.Zhang, Z., Vuori, K., Wang, H.G., Reed, J.C., Ruoslahti, E.(1996) Integrin activation by R-ras. Cell 85: 61-69.

20.Zhang, Z., Vekemans, S., Aly, M.S., Jaspers, M., Marynen, P., and Cassiman, J.J. (1991) The gene for the alpha 4 subunit of the VLA-4 integrin maps to chromosome 2q31-32. Blood 78: 2396-99.

21.Zhang, Z., Morla, A.O., Vuori, K., Buar, J.S., Juliano, R.L., and Ruoslahti, E. (1993) The avb1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin. J Cell Biol 122:235-42.