1988.09-1992.06，湖南师范大学生命科学学院生物学专业，理学学士

1992.09-1995.06，湖南师范大学生命科学学院生物化学专业，理学硕士

1995.09-1998.06，中国科学院上海生物化学与细胞生物学研究所分子生物学专业，理学博士

1．病毒感染和宿主免疫及肿瘤发生中的蛋白质脱酰胺化修饰研究

蛋白质脱酰胺化修饰在微生物感染与致病过程中的作用已经逐渐被人们所认识。我们在前期工作的基础上，开展对禽流感、中东呼吸综合症、寨卡和疱疹病毒感染和宿主免疫过程中的蛋白质脱酰胺化修饰的调控作用的研究，探究病毒劫持宿主的代谢酶进行蛋白质脱酰胺化修饰的调控机制，以及这种调控对病毒感染和宿主免疫的生理和病理意义。同时我们也将探究这种修饰在恶性肿瘤发生中的调控作用。该项工作与美国南加州大学的冯平辉教授进行深度合作。

2．肿瘤发生中泛素化蛋白的蛋白质组学研究

探索并运用新的蛋白质组学方法对肿瘤组织、肿瘤细胞和肿瘤干细胞的泛素化蛋白进行全蛋白质组学（global proteomics）分析，发现新的泛素化修饰底物及潜在的分子标记。

3．肿瘤免疫治疗之CAR-T和TCR-T细胞治疗技术的开发和应用

CAR-T技术是目前最有前途的肿瘤免疫治疗新策略，对血液肿瘤的治疗特别有效，然而对实体瘤的效果有限。研究组将对现有的技术进行改造，以期在实体瘤的CAR-T治疗方向取得突破。另外由于TCR-T技术在实体瘤治疗的临床试验中显示了很好的疗效，实验室通过与企业合作，联合开发TCR-T细胞治疗技术。

.Zhang J, Zhao J, Xu S, Li J, He S, Zeng Y, Xie L, Xie N, Liu T, Lee K, Seo GJ, Chen L, Stabell AC, Xia Z, Sawyer SL, Jung J, Huang C, Feng P (2018) Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication. Cell Host & Microbe, 2018 Aug 8;24(2):234-248.e5. doi: 10.1016/j.chom.2018.07.004.

2.Zhang Z, Zhu Z, Chen W, Cai Z, Xu B, Tan Z, Wu A, Ge X, Guo X, Tan Z, Xia Z, Zhu H, Jiang T, Peng Y (2018) Cell membrane proteins with high N-glycosylation, high expression, and multiple interaction partners are preferred by mammalian viruses as receptors. Bioinformatics, 2018 Aug 9. doi: 10.1093/bioinformatics/bty694. [Epub ahead of print]

3.Chengming Ding, Jun He, Jun Zhao, Junhua Li, Jie Chen, Wenyan Liao, Yi Zeng, Jing Zhong, Chaoying Wei, Liming Zhang, Mei Zhou, Zeming Jia, Yaoting Zhang, Hui Li, Yuzheng Zhou, Xiaolong Xiao, Dong Han, Chong Li, Zhu Zhu, Zanxian Xia*, and Jian Peng* (2018) b-catenin regulates IRF3- mediated innate immune signalling in colorectal cancer. Cell Prolif, 2018 Jul 13:e12464. doi: 10.1111/cpr.12464. [Epub ahead of print]

4.Jie Chen, Jun Zhao, Xuan Chen, Chengming Ding, Katie Lee, Zeming Jia, Yaoting Zhang, Yuzheng Zhou, Chaoying Wei, Jiantai He, Zanxian Xia*, and Jian Peng* (2017) Hyper activation of β-catenin signalling induced by IKKε inhibition thwarts colorectal cancer cell proliferation. Cell Prolif, 2017 Aug; 50(4). doi: 10.1111/cpr.12350

5.Junjie Zhang, Mao Tian, Zanxian Xia, Pinghui Feng (2016) Roles of IκB kinase ε in the innate immune defense and beyond. Virologica Sinica, 2016 Dec; 31 (6): 457–465

6.Xiaoqing Zhang, Haiyang Yu, Jun Zhao, Xiuqing Li, Jiada Li, Jiantai He, Zanxian Xia* and Jinfeng Zhao* (2016) IKKϵ negatively regulates RIG-I via direct phosphorylation. J Med Virol, 2016 Apr; 88(4):712-8

7.Jun Zhao, Yi Zeng, Simin Xu, Jie Chen, Caiqun Yu, Guobo Shen, David Knipe, Weiming Yuan, Jian Peng, Wenqing Xu, Chao Zhang, Zanxian Xia, and Pinghui Feng (2016) A viral deamidase targets the helicase domain of RIG-I to block RNA-induced activation. Cell Host & Microbe, 2016 Dec; 20(6):770-784.

8.Junjie Zhang, Lining Zhu, Xiaolu Lu, Emily R. Feldman, Lisa R. Keyes, Yi Wang, Hui Fan, Hao Feng, Zanxian Xia, Jiya Sun, Taijiao Jiang, Shou-jiang Gao, Scott A. Tibbetts, and Pinghui Feng (2015) Recombinant murine gamma herpesvirus 68 carrying KSHV G protein-coupled receptor induces angiogenic lesions in mice. PLoS Pathogens, 2015 Jun; 11(6): e1005001

9.Zanxian Xia*, Mingquan Guo, Han Liu, Luwei Jiang, Qiaoxia Li, Jian Peng, Jia-Da Li, Baoen Shan, Pinghui Feng, and Hong Ma* (2015) CBP-dependent Wnt/β-catenin signaling is crucial in regulation of MDR1 transcription. Current Cancer Drug Targets, 2015; 15(6):519-32

10.Hong Ma*, Mingquan Guo, Baoen Shan, and Zanxian Xia* (2012) Targeted functional analysis of p300 coactivator in Wnt/β-catenin signaling pathway using phosphoproteomic and biochemical approaches. Journal of Proteomics, 75(9):2601-10

11.Zanxian Xia, Mingquan Guo, and Hong Ma (2011) Functional analysis of novel phosphorylation sites of CREB-binding protein using mass spectrometry and mammalian two-hybrid assays. Proteomics, 11(17): 3444-51

12.Mingquan Guo#, Zanxian Xia#, and Hong Ma (2011) Functional phosphosite screening for targeted protein-protein interactions by combining phosphoproteomics strategies and mammalian two-hybrid assays. Mol Biosyst, 7(6): 1838-41

13.Zanxian Xia, Glenn C. Turner, Cheol-Sang Hwang, Christopher Byrd, and Alexander Varshavsky (2008) Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter. J Biol Chem, 283(43): 28958-68

14.Zanxian Xia, Ailsa Webster, Fangyong Du, Konstantin Piatkov, Michel Ghislain, and Alexander Varshavsky (2008) Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway. J Biol Chem, 283(35): 24011-24028