教育背景
1997年毕业于华中农业大学,获植物保护学士学位。
1999年考入浙江大学攻读硕士学位,2004年毕业于浙江大学。
工作经历
09/2012-现在,华中农业大学植物科技学院药用植物研究所教授、药用植物教研室主任。
12/2009-08/2012, 研究助理, 康乃尔大学,生物医学工程系(Research Associate, Biomedical Engineering Department, Cornell University)
11/2006-11/2009, 博士后,康乃尔大学,生物医学工程系(Postdoctoral Associate,Biomedical Engineering Department, Cornell University)
07/2004-10/2006, 助理研究员,中国科学院微生物研究所
项目课题经历
科技部重点研发、国家外专局、学校自主创新等项目
论文、成果、著作等
1. Mohammad Omar Faruque, Gang Feng, Md. Nurul Amin Khan, James W. Barlow, Umme Ruman Ankhi, Sheng Hu, M. Kamaruzzaman, Shaikh Bokhtear Uddin#, Xuebo Hu#. Qualitative and quantitative ethnobotanical study of the Pangkhua community in Bilaichari Upazilla, Rangamati District, Bangladesh. Journal of Ethonobiology and Ethnomedicine. Accepted. 2019.
2. Jafari M, Akram W, Pang Y, Ahmad A, Ahmed S, Yasin NA, Anjum T, Ali B, Hu X, Li X, Dong S, Cai Q, Ciprian M, Bielec M, Hu S, Sefidkon F, Hu X*.Genetic diversity and biogeography of T. officinale inferred from multi locus sequence typing approach.PLoS One. 2018 Sep 18;13(9):e0203275
3. Zhang Q, Hu S, Wang K, Cui M, Li X, Wang M, Hu X*. Engineering a yeast double-molecule carrier for drug screening. Artif Cells Nanomed Biotechnol. 2018 Apr 3:1-11
4. Faruque MO, Uddin SB, Barlow JW, Hu S, Dong S, Cai Q, Li X, Hu X*.Quantitative Ethnobotany of Medicinal Plants Used by Indigenous Communities in the Bandarban District of Bangladesh.Front Pharmacol. 2018 Feb 6;9:40
5. Zhan C, Ahmed S, Hu S, Dong S, Cai Q, Yang T, Wang X, Li X, Hu X*.Cytochrome P450 CYP716A254 catalyzes the formation of oleanolic acid from β-amyrin during oleanane-type triterpenoid saponins biosynthesis in Anemone flaccida.Biochem Biophys Res Commun. 2018 Jan 1;495(1):1271-1277
6. Ahmed S, Liu H, Ahmad A, Akram W, Abdelrahman EKN, Ran F, Ou W, Dong S, Cai Q, Zhang Q, Li X, Hu S, Hu X*. Characterization of Anti-bacterial Compounds from the Seed Coat of Chinese Windmill Palm Tree (Trachycarpus fortunei).Front Microbiol. 2017 Oct 4;8:1894
7. Hu Y, Ahmed S, Li J, Luo B, Gao Z, Zhang Q, Li X, Hu X*.Improved ganoderic acids production in Ganoderma lucidum by wood decaying components.Sci Rep. 2017 Apr 19;7:46623
8. Zhan C, Li X, Zhao Z, Yang T, Wang X, Luo B, Zhang Q, Hu Y, Hu X*. Comprehensive Analysis of the Triterpenoid Saponins Biosynthetic Pathway in Anemone flaccida by Transcriptome and Proteome Profiling. Front Plant Sci. 2016, 7:1094
9. Ahmed S, Zhan C, Yang Y, Wang X, Yang T, Zhao Z, Zhang Q, Li X, Hu X*. The Transcript Profile of a Traditional Chinese Medicine, Atractylodes lancea, Revealing Its Sesquiterpenoid Biosynthesis of the Major Active Components. PLoS One. 2016 Mar 18;11(3):e0151975
10. Xin-Mei Zhao, Zhang-Qian Wang, Shao-Hua Shu, Wen-Juan Wang, Hai-Jie Xu, Young-Joon Ahn, Mo Wang*, Xuebo Hu* Ethanol and Methanol Can Improve Huperzine A Production From Endophytic Colletotrichum gloeosporioides ES026. Plos One 2013, 8:e61777.
11. Xuebo Hu, P. Saha, Xiaoyue Chen, Dogeun Kim, Mahesh Devarasetty, Raghavan Varadarajan, Moonsoo Jin. Cell Surface Assembly of HIV gp41 Six-Helix Bundles for Facile, Quantitative Measurements of Hetero-oligomeric Interactions. J. Am. Chem. Soc. 2012, 134:14642-14645.
12. Jacque M Tremblay, Chueh-Ling Kuo, Claudia Abeijon, Jorge Sepulveda, George Oyler, Xuebo Hu, Moonsoo M Jin, Charles B Shoemaker. Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases. Toxicon, 2010,56:990-998.
13. Xuebo Hu, Sungkwon Kang, Craig Lefort, Minsoo Kim, Moonsoo Jin. Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies. Proc. Natl. Acad. Sci. U. S. A. 2010,107: 6252-6257.
14. Xuebo Hu, Sungkwon Kang, Xiaoyue Chen, Shoemaker CB, Moonsoo Jin. Yeast surface two-hybrid for quantitative in vivo detection of protein-protein interactions via the secretory pathway. J Biol Chem. 2009 12;284(24):16369-76.
15. Xuebo Hu, Huijuan Zhang, Guojun Li, Yuxia Yang, Zhong Zheng, Fengming Song. Ectopic expression of a rice protein phosphatase 2C gene OsBIPP2C2 in tobacco improves disease resistance. Plant Cell Rep. 2009, 28(6):985-95.
16. Chaozheng Zhang , Yueyong Liu , Liyue Liu , Zhiyong Lou, Hongyan Zhang, Hongqin Miao, Xuebo Hu, Yanping Pang, Bingsheng Qiu. Rice black streaked dwarf virus P9-1, an alpha-helical protein, self-interacts and forms viroplasms in vivo. J Gen Virol. 2008 89:1770-1776.
17. Xuebo Hu, Fengming Song, Zhong Zheng. Molecular characterization and expression analysis of a rice protein phosphatase 2C gene, OsBIPP2C1, and overexpression in transgenic tobacco conferred enhanced disease resistance and abiotic tolerance. Physiol Plant. 2006,127: 225-236.
18. Yueyong Liu, Yanhui Xu, Zhiyong Lou, Jieqing Zhu, Xuebo Hu, George F. Gao, Bingsheng Qiu, Zihe Rao, Po Tien. Structural characterization of Mumps virus fusion protein core. Biochem. Biophys. Res. Commun. 2006, 348:916-922.
19. Xuebo Hu, Fengming Song, Zhong Zheng. Molecular cloning and expression of rice OsTVLP1, encoding a protecin with similarity to TGF-belta receptor interacting proteins and vacuolar assembly Vam6p/Vps39p proteins. DNA Seq. 2006 17(2):152-158.
20. Yong Li, Mingyu Wu, Houhui Song, Xuebo Hu, Bingsheng Qiu. Identification of a tobacco protein interacting with tomato mosaic virus coat protein and facilitating long-distance movement of virus. Arch Virol 2005, 150:1993-2008.
21. Yueyong Liu, Yong Li, Liyue Liu, Xuebo Hu, Bingsheng Qiu. Design of vectors for efficient integration and transformation in Hansenula polymorpha. Biotech Lett. 2005, 27(19):1529-1534.
专利、著作版权等
胡学博,王嘉男,田倩川。一种利用人微血管内表皮细胞检测凉茶抗炎活性的方法。申请号,201610819586.2;
胡学博,王嘉男。一种利用人微血管内表皮细胞ICAM-1蛋白表达量检测凉茶抗炎活性的方法。申请号,20161081953662;
胡学博,张启云。一种双通道蛋白表达的工程酵母的构建方法。申请号,2016101903665;
胡学博,张启云。基于ICAM-1信号通路的高通量药物筛选模型的建立方法。申请号,20161009718882;
胡学博,胡延如。一种提高灵芝菌丝体液体发酵的胞内灵芝三萜含量的方法。申请号,2016100721790;
胡学博,李嘉伟,胡延如。一种基于温度控制提高灵芝菌丝体液体发酵的胞内灵芝三萜含量的方法。 申请号, 201610784316.3;
胡学博,李嘉伟。一种高胞内灵芝三萜含量的灵芝菌丝体发酵工艺。申请号,2016111805855.5;
胡学博,李嘉伟。一种茯苓菌丝体液体发酵方法。申请号:201710058472.6。
“A Yeast Surface Two-Hybrid System for Quantitative Detection of Protein-Protein Interactions”, Pending. Second petitioner. 美国专利,受理中. 第二申请人。
“The esterase of chrysanthemic acid, its encoding gene, engineered expressing strains and their applications”. Chinese Patent No. CN1766097, 2006. 中国专利,第三申请人。
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