教育背景
1982/09~1986/07:西南农业大学农学系,本科,学士
1989/09~1992/07:南京农业大学作物遗传育种专业,硕士,导师:盖钧镒教授
1997/08~1998/01:东南大学应用数学系,访问学者
2000/09~2001/12:南京农业大学作物遗传育种专业,博士,导师:盖钧镒教授
2003/01~2005/01:The University of California, Riverside, Dept. of Botany and Plant Science, 博士后,合作导师: Цᯬ
工作经历
1、华中农业大学植物科技学院教授,主要从事数量遗传学理论与应用研究、作物分子进化研究;
2、南京农业大学农学院作物遗传育种专业,历任副教授(1999.11)和教授(2002.04),从事统计基因组学、基因分子进化和大豆遗传学研究工作;其中,2003.01~2005.01年在美国加州大学Riverside分校做统计遗传与基因组学博士后;
3、西南大学荣昌分校,历任见习助教、助教(1987.12)、讲师(1992.12)、副教授(1995.12);从事生物统计学教学及其应用研究工作。
项目课题经历
1、主持国家自然科学基金项目(高通量快速检测含有杂合基因型关联群体的多位点GWAS方法学研究及其软件包研制 31871242)(2018)
2、主持棉花生物学国家重点实验室开放课题(2017)
3、参加NSFC-云南联合基金重点项目(玉米抗灰斑病遗传机制分析、功能位点发掘和育种应用研究U1602261)(2016)
4、主持国家自然科学基金项目(海量SNP、高精度和快速检测的多位点关联分析新方法及其应用研究31571268)(2015)
5、主持华中农业大学引进人才项目1项(2014)
6、参加973项目2项(2006CB101708,2006;2011CB109300,2010)
7、主持国家自然科学基金项目3项(30470998,2004;30671333,2007;30971848,2009);学术指导国家自然科学青年基金项目5项(30900842;31000666;31301004;31301229;31601209)
8、主持教育部新世纪优秀人才支持计划项目1项(2005)
9、主持教育部高校博士点基金项目3项(2006;2010;2012)
10、主持教育部与人事部留学回国人员启动基金项目各1项(2005)
11、主持江苏省自然科学基金项目2项(2005,2008)、重庆市应用基础研究项目1项(1999)
12、主持中央高校基本科研业务费创新团队项目1项(2010)、参与中央高校基本科研业务费项目1项(2012)
13、主持作物遗传与种质创新国家重点实验室自主创新项目1项(2009)
论文、成果、著作等
2019
1. Zhang Yuan-Ming*, Jia Zhenyu, Jim M. Dunwell. Editorial: The Applications of New Multi-Locus GWAS Methodologies in the Genetic Dissection of Complex Traits. Frontiers in Plant Science 9: 100. DOI: 10.3389/fpls.2019.00100
2. Zhang Hongwei#, Wang Xi#, Pan Qingchun#, Li Pei#, Liu Yunjun, Lu Xiaoduo, Zhong Wanshun, Li Minqi, Han Linqian, Juan Li, Wang Pingxi, Li Dongdong, Liu Yan, Li Qing, Yang Fang, Zhang Yuan-Ming*, Wang Guoying*, Li Lin*. QTG-seq accelerates QTL fine mapping through QTL partitioning and whole-genome sequencing on bulked segregant samples. Molecular Plant, online, 2018-12-28, https://doi.org/10.1016/j.molp.2018.12.018.
3. Wen Yang-Jun, Zhang Ya-Wen, Zhang Jin, Feng Jian-Ying, Jim M Dunwell, Zhang Yuan-Ming*. An efficient multi-locus mixed model framework for the detection of small and linked QTLs in F2. Briefings in Bioinformatics, bby058, https://doi.org/10.1093/bib/bby058, 18 July 2018
2018
4. Zhang Zhibin, Jim M Dunwell, Zhang Yuan-Ming*. An integrated omics analysis reveals molecular mechanisms that are associated with differences in seed oil content between Glycine max and Brassica napus. BMC Plant Biology, 2018, 18: 328.
5. Zhang Li#, Liu Jin-Yang#, Gu Huan, Du Yanfang, Zuo Jian-Fang, Zhang Zhibin, Zhang Menglin, Li Pan, Jim M. Dunwell, Cao Yangrong, Zhang Zuxin*, Zhang Yuan-Ming*. Bradyrhizobium diazoefficiens USDA 110-Glycine max interactome provides candidate proteins associated with symbiosis. Journal of Proteome Research 2018, 17(9): 3061-3074. (cover paper)
6. Wen Yang-Jun, Zhang Hanwen, Ni Yuan-Li, Huang Bo, Zhang Jin, Feng Jian-Ying, Wang Shi-Bo, Jim M. Dunwell, Zhang Yuan-Ming*, Wu Rongling*. Methodological implementation of mixed linear models in multi-locus genome-wide association studies. Briefings in Bioinformatics 2018, 19(4): 700-712
7. Wen-Long Ren#, Yang-Jun Wen#, Jim M. Dunwell, Yuan-Ming Zhang*. pKWmEB: integration of Kruskal-Wallis test with empirical Bayes under polygenic background control for multi-locus genome-wide association study. Heredity 2018, 120(3): 208-218
2017
8. Li Wen-Ting#, Zhang Meng-Meng#, Li Qi-Gang#, Tang Hui, Zhang Li-Fan, Wang Ke-Jun, Zhu Mu-Zhen, Lu Yun-Feng, Bao Hai-Gang, Zhang Yuan-Ming*, Li Qiu-Yan*, Wu Ke-Liang*, Wu Chang-Xin. Whole-genome resequencing reveals candidate mutations for pig prolificacy. Proceedings of the Royal Society Biological Sciences 2017, 284(1869): 20172437.
9. Zhang Jin#, Feng Jian-Ying#, Ni Yuan-Li, Wen Yang-Jun, Niu Yuan, Tamba Cox Lwaka, Yue Chao, Song Qijian, Zhang Yuan-Ming*. pLARmEB: integration of least angle regression with empirical Bayes for multi-locus genome-wide association studies. Heredity 2017, 118(6): 517-524 (Featured Article)
10. Tamba Cox Lwaka, Ni Yuan-Li, Zhang Yuan-Ming*. Iterative sure independence screening EM-Bayesian LASSO algorithm for multi-locus genome-wide association studies. PLoS Computational Biology 2017, 13(1): e1005357
11. Zhang Yuan-Ming*, Zhang Yinghao, Guo Mingyue. Epigenetic game theory and its application in plants. Physics of Life Reviews 2017, 20: 158-160
2016
12. Wang Shi-Bo, Wen Yang-Jun, Ren Wen-Long, Ni Yuan-Li, Zhang Jin, Feng Jian-Ying, Zhang Yuan-Ming*. Mapping small-effect and linked quantitative trait loci for complex traits in backcross or DH populations via a multi-locus GWAS methodology. Scientific Reports 2016, 6: 29951
13. Zeng Yan-Da, Sun Jun-Ling, Bu Su-Hong, Deng Kang-Sheng, Tao Tao, Zhang Yuan-Ming, Zhang Tianzhen, Du Xiong-Ming*, Zhou Bao-Liang*. EcoTILLING revealed SNPs in GhSus genes that are associated with fiber- and seed-related traits in upland cotton. Scientific Reports 2016, 6: 29250
14. Zhang Li, Wang Shi-Bo, Li Qi-Gang, Song Jian, Hao Yu-Qi, Zhou Ling, Zheng Huan-Quan, Jim M Dunwell, Zhang Yuan-Ming*. 2016. An integrated bioinformatics analysis reveals divergent evolutionary pattern of oil biosynthesis in high- and low-oil plants. PLoS ONE, 11(5): e0154882
15. Zhou Ling, Luo Longhai, Zuo Jian-Fang, Yang Linfeng, Zhang Li, Guang Xuanmin, Niu Yuan, Jian Jianbo, Geng Qing-Chun, Liang Liping, Song Qijian, Jim M Dunwell, Wu Zhenzhen, Wen Jia, Liu Yu-Qin, Zhang Yuan-Ming*. 2016. Identification and validation of candidate genes associated with domesticated and improved traits in soybean. The Plant Genome 9, doi:10.3835/plantgenome2015. 09.0090
16. Wang Shi-Bo, Feng Jian-Ying, Ren Wen-Long, Huang Bo, Zhou Ling, Wen Yang-Jun, Zhang Jin, Jim M. Dunwell, Xu Shizhong*, Zhang Yuan-Ming*. 2016. Improving power and accuracy of genome-wide association studies via a multi-locus mixed linear model methodology. Scientific Reports 6: 19444
2015
17. Wen Jia, Zhao Xinwang, Wu Guorong, Xiang Dan, Liu Qing, Bu Su-Hong, Yi Can, Song Qijian, Jim M. Dunwell, Tu Jinxing, Zhang Tianzhen, Zhang Yuan-Ming*. Genetic dissection of heterosis using epistatic association mapping in a partial NCII mating design. Scientific Reports 2015, 5: 18376
18. Zhou Ling#, Wang Shi-Bo#, Jian Jianbo#, Geng Qing-Chun, Wen Jia, Song Qijian, Wu Zhenzhen, Li Guang-Jun, Liu Yu-Qin, Jim M. Dunwell, Zhang Jin, Feng Jian-Ying Feng, Niu Yuan, Zhang Li, Ren Wen-Long, Zhang Yuan-Ming*. 2015. Identification of domestication-related loci associated with flowering time and seed size in soybean with the RAD-seq genotyping method. Scientific Reports 5: 9350
19. Bu Su-Hong#, Zhao Xinwang#, Yi Can, Wen Jia, Tu Jinxing, Yuan-Ming Zhang*. Interacted QTL mapping in partial NCII design provides evidences for breeding by design. PLoS ONE 10(3): e0121034
20. Li Lanzhi, He Xiaohong, Zhang Hongyan, Wang Zhiming, Sun Congwei, Mou Tongmin, Li Xinqi, Zhang Yuanming, Hu Zhongli*. 20015. Genomewide mapping reveals a combination of different genetic effects causing the genetic basis of heterosis in two elite rice hybrids. Journal of Genetics 94(2): 261-270
2014
21. Li Meng, Liu Xiaolei, Peter Bradbury, Yu Jianming, Zhang Yuan-Ming*, Rory J Todhunter, Edward S Buckler, Zhang Zhiwu*. 2014. Enrichment of statistical power for genome-wide association studies. BMC Biology 12:73
22. Xie S-Q, Feng J-Y, Zhang Y-M*. 2014. Linkage group correction using epistatic distorted markers in F2 and backcross populations. Heredity 112: 479-488
23. Zhang W-J, Niu Y, Bu S-H, Li M, Feng J-Y, Zhang J, Yang S-X, Medrine Mmyi Odinga, Wei S-P, Liu X-F, Zhang Y-M*. 2014. Epistatic association mapping for alkaline and salinity tolerance traits in the soybean germination stage. PLoS ONE 9(1): e84750
24. Xie F-T, Niu Y, Zhang J, Bu S-H, Zhang H-Z, Geng Q-C, Feng J-Y, Zhang Y-M*. 2014. Fine mapping of quantitative trait loci for seed size traits in soybean. Molecular Breeding 34(4): 2165-2179
2013
25. Li Qi-Gang, Zhang Li, Li Chun, Jim M. Dunwell, Zhang Y-M*. 2013. Comparative genomics suggests that an ancestral polyploidy event leads to enhanced root nodule symbiosis in the Papilionoideae. Molecular Biology and Evolution 30(12): 2602-2611
26. Li Q-G, Zhang Y-M*. 2013. The origin and functional transition of P34. Heredity 110(3): 259-266
27. Wen Jia, Can Van Toan, Zhang Y-M*. 2013. Multi-QTL mapping for quantitative traits using distorted markers. Molecular Breeding 31(2): 395-404
28. Niu Yuan, Xu Yu, Liu Xiao-Feng, Yang Sheng-Xian, Wei Shi-Ping, Xie Fang-Teng, Zhang Yuan-Ming*. 2013. Association mapping for seed size and shape traits in soybean cultivars. Molecular Breeding 31(4): 785-794
29. Xie Shang-Qian, Jia Wen, Zhang Yuan-Ming*. 2013. Multi-QTL mapping for quantitative traits using epistatic distorted markers. PLoS ONE 8(7): e68510
30. Feng J-Y, Zhang J, Zhang W-J, Wang S-B, Han S-F, Zhang Y-M*. 2013. An efficient hierarchical generalized linear mixed model for mapping QTL of ordinal traits in crop cultivars. PLoS ONE 8(4): e59541
31. Zhang T*, Qian N, Zhu X, Chen H, Wang S, Mei H, Zhang Y. 2013. Variations and transmission of QTL alleles for yield and fiber qualities in upland cotton cultivars developed in China. PLoS ONE 8(2): e57220
2012
32. Li C, Li Q-G, Jim M. Dunwell, Zhang Y-M*. 2012. Divergent evolutionary pattern of starch biosynthetic pathway genes in grasses and dicots. Molecular Biology and Evolution 29(10): 3227- 3236
33. Zhang J, Yue C, Zhang Y-M*. 2012. Bias correction for estimated QTL effects using the penalized maximum likelihood method. Heredity 108: 396-402
34. Li C, Li M, Jim M. Dunwell, Zhang Y-M*. 2012. Gene duplication and accelerated evolutionary rate contribute to the higher ability of protein synthesis in dicots. BMC Evolutionary Biology 12: 15
35. He Xiao-Hong, Hu Zhongli, Zhang Yuan-Ming*. 2012. Genome-wide mapping of QTL associated with heterosis in the RIL-based NCIII design. Chin Sci Bull 57(21): 2655-2665
36. Liu R, Wang B, Guo W, Qin Y, Wang L, Zhang Y, Zhang T*. 2012. Quantitative trait loci mapping for yield and its components by using two immortalized populations of a heterotic hybrid in Gossypium hirsutum L. Molecular Breeding 29(2): 297-311
37. Zhou Jiangbo, Zhang Yuan-Ming, Lü Haiyan, You Aiqing, Zhu Lili, He Guangcun*. 2012. Transmission of important chromosomal regions under selection revealed in rice pedigree breeding programs. Molecular Breeding 30(2): 717-729
38. Chen X, Guo W, Liu B, Zhang Y, Song X, Zhang L, Zhang T*. 2012. Molecular mechanisms of fiber differential development between G. barbadense and G. hirsutum revealed by genetical genomics. PLoS ONE 7(1): e30056
39. Guo H-L, Li Y, Xuan J-P, Liu J-X*, Zhang Y-M, Zheng Yi-Qi. 2012. Association of molecular markers with cold tolerance and green period in Zoysiagrass (Zoysia Willd.). Breeding Science 62: 320-327
2011
40. Li C, Zhang Y-M*. 2011. Molecular evolution of glycinin and β-conglycinin gene families in soybean (Glycine max L. Merr.). Heredity 106: 633-641
41. Xu Y, Li H-N, Li G, Wang X, Cheng L, Zhang Y-M*. 2011. Mapping quantitative trait loci for seed size traits in soybean (Glycine max L. Merr.). Theor Appl Genet 122: 581-594
42. He X-H, Qin H, Hu Z, Zhang T, Zhang Y-M*. 2011. Mapping of epistatic quantitative trait loci in four-way crosses. Theor Appl Genet 122: 33-48
43. Lü H-Y, Liu X-F, Wei S-P, Zhang Y-M*. 2011. Epistatic association mapping in homozygous crop cultivars. PLoS ONE 6(3): e17773
44. He X-H, Zhang Y-M*. 2011. A complete solution for dissecting pure main and epistatic effects of QTL in triple testcross design. PLoS ONE 6(9): e24575
45. Kuang F-L, Wang X, Zhou L, Zhang Y-M*. 2011. Linkage graph analysis: A linkage-group-based QTL synthesis analysis approach. China Sci Bull 56: 1092-1099
46. Zhu X, Ai N, Zhang Y, Guo W, Zhang T-Z*. 2011. Relationships between differential gene expression and heterosis in cotton hybrids developed from the foundation parent CRI-12 and its pedigree-derived lines. Plant Science 180: 221-227
2010
47. Dou BD*, Hou BW, Wang F, Yang JB, Ni ZF, Sun QX, Zhang Y-M*. 2010. Further mapping of quantitative trait loci for female sterility in wheat. Genetics Research 92(1): 63-70
48. Liu G, Li M, Wen J, Du Y, Zhang Y-M*. 2010. Functional mapping of quantitative trait loci associated with rice tillering. Molecular Genetics and Genomics 284: 263-271
49. Li G-J, LI H-N, Cheng L-G, Zhang Y-M*. 2010. QTL Analysis for Dynamic Expression of Chlorophyll Content in Soybean (Glycine max L. Merr.). Acta Agronomica Sinica 36(2): 242-248
2009
50. Lü H-Y, Li M, Yao L-L, Li G-J, Lin F, Zhang Y-M*. 2009. Multi-loci in silico mapping in inbred lines. Heredity 103: 346-354
51. Zhang Y-M*, Gai JY. 2009. Methodologies for segregation analysis and QTL mapping in plant. The third International Conference on Quantitative Genetics. Genetica 136: 311-318
2008
52. He X-H, Zhang Y-M*. 2008. Mapping epistatic quantitative trait loci underlying endosperm traits using all markers on the entire genome in random hybridization design. Heredity 101: 39-47
53. Zhang Y-M*, Lü H-Y, Yao L-L. 2008. Multiple quantitative trait loci Haseman-Elston regression using all markers on the entire genome. Theor Appl Genet 117: 683-690
54. Zhu C, Zhang Y-M*, Guo Z. 2008. Mapping quantitative trait loci for binary trait in the F2:3 design. Journal of Genetics 87(3): 201-207
55. Qin H, Guo W, Zhang Y-M, Zhang TZ*. 2008. QTL mapping of yield and fiber traits based on a four-way cross population in Gossypium hirsutum L. Theor Appl Genet 117: 883-894
2007
56. Zhu C, Wang C, Zhang Y-M*. 2007. Modeling segregation distortion for viability selection I. Reconstruction of linkage maps with distorted markers. Theor Appl Genet 114: 295-305
57. Zhu C, Zhang Y-M*. 2007. An EM algorithm for mapping segregation distortion loci. BMC Genetics 8: 82
58. Zhu C, Huang J, Zhang Y-M*. 2007. Mapping binary trait loci in the F2:3 design. Journal of Heredity 98: 337-344
59. Geng J, Zhu C, Zhang X, Cheng Y, Zhang Y-M*, Hou X*. 2007. A genetic linkage map of nonheading chinese cabbage. Journal of American Society for Horticultural Science 132: 816-823
60. Zhu C, Wang F, Wang J,Li G,Zhang H*, Zhang Y-M*. 2007. Reconstruction of linkage maps in the segregation populations of backcross, double haploid and recombinant inbred line. Chin Sci Bull 52: 1648-1653
61. Wang X, Hu Z, Wang W, Li Y, Zhang Y-M, Xu C*. 2007. A mixture model approach to the mapping of QTL controlling endosperm traits with bulked samples Status. Genetica 132: 59-70
2006
62. Zhang Y-M*. 2006. Advances on methods for mapping QTL in plants. China Sci Bull 51: 2223-2231
63. Zhang Y-M*. 2006. Shrinkage estimation method for mapping multiple quantitative trait loci. Acta Genetica Sinica 33(10): 861-869
64. Xue Y, Wan J*, Jiang L, Wang C, Liu L, Zhang Y-M, Zhai H. 2006. Identification of quantitative trait loci associated with aluminum tolerance in rice (Oryza sativa L.). Euphytica 150: 37-45
2005
65. Zhang Y-M, Mao Y, Xie C, Smith H, Luo L, Xu S*. 2005. Mapping quantitative trait loci using naturally occurring genetic variance among commercial inbred lines of maize (Zea mays L.). Genetics 169: 2267-2275
66. Wang H, Zhang Y-M, Li X, Masinde GL, Mohan S, Baylink DJ, Xu S*. 2005. Bayesian shrinkage estimation of quantitative trait loci parameters. Genetics 170: 465-480 (Comment: Nat Rev Genet 2006, 7: 229-237)
67. Zhang Y-M, Xu S*. 2005. A penalized maximum likelihood method for estimating epistatic effects of QTL. Heredity 95: 96-104
68. Luo L, Zhang Y-M, Xu S*. 2005. A quantitative genetics model for viability selection. Heredity 94: 347-355 (Featured Article)
69. Xu C, Zhang Y-M, Xu S*. 2005. An EM algorithm for mapping quantitative resistance loci. Heredity 94: 119-128
70. Zhang Y-M, Xu S*. 2005. Advanced statistical methods for detecting multiple quantitative trait loci. Recent Research Developments in Genetics and Breeding 2: 1-23 (Invited Review)
71. Hansen C, Yi N, Zhang Y-M, Xu S, Gavora J, Cheng HH*. 2005. Identification of QTL for production traits in chickens. Animal Biotechnology 16: 67-79
2004
72. Zhang Y-M, Xu S*. 2004. Mapping quantitative trait loci in F2 incorporating phenotypes of F3 progeny. Genetics 166: 1981-1993
2003
73. Zhang Y-M*, Gai JY, Yang Y-H. 2003. The EIM algorithm in the joint segregation analysis of quantitative traits. Genetics Research 81: 157-163
74. Tao A, Zeng H, Zhang Y-M,Xie G-S, Qin F-L, Zheng Y-L, Zhang D-P*. 2003. Genetic analysis of the low critical sterility temperature point in photoperiod-thermo sensitive genic male sterile rice. Acta Genetica Sinica 30(1): 40-48
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