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付彩云

领域:生物产业 学校:浙江理工大学职称:副教授

1. 小分子靶向药研发与肿瘤靶向治疗 2. 多肽药理学...

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教育背景

1. 1999.09-2003.06 兰州大学生命科学学院生物学基地班,学士 (班主任:张迎梅教授)

2. 2003.09-2008.06 兰州大学生命科学学院生物化学与分子生物学研究所,硕博连读,理学博士(导师:王锐教授)

工作经历

3. 2008.12-至今  浙江理工大学,生命科学学院讲师,副教授(2019.04 特聘教授)

项目课题经历

1. 哺乳动物速激肽hemokinin-1的中枢镇痛位点和镇痛机制研究(项目编号31000496),国家自然科学基金青年基金,21万元,2011.1-2013.12,排名1/9,主持结题;

2. 靶向阻断神经激肽受体抑制白血病细胞生长的分子机制及其在白血病治疗中的潜在价值(项目编号31470071),国家自然科学基金面上项目,30万元,2015.1-2016.12,排名1/10,主持在研;

3. 沙瑞度坦抑制人粒性白血病细胞增殖的靶点蛋白筛选及其功能研究(项目编号LY14C050003),浙江省自然科学基金面上项目,8万元,2014.01-2016.12,排名1/5,主持在研;

4. Neurokinin Receptors激动剂诱导小鼠红白血病细胞MEL分化的作用及调控研究(项目编号Y200909697),浙江省教育厅项目,厅局级,1.2万元,2009.12-2011.12,排名1/6,主持结题

论文、成果、著作等

1. Lu Y, Zhang TF, Shi Y, Zhou HW, Chen Q, Wei BY, Wang X, Yang TX, Chinn YE, Kang J, Fu CY*. PFR peptide, one of the antimicrobial peptides identified from the derivatives of lactoferrin, induces necrosis in leukemia cells. Scientific Reports. 2016, 6: 20823. (corresponding author)

2. Zou Y, Guo CG, Yang ZG, Sun JH, Zhang MM*, Fu CY*. A small interfering RNA targeting vascular endothelial growth factor efficiently inhibits growth of VX2 cells and VX2 tumor model for hepatocellular carcinoma in rabbit by transarterial embolization-mediated siRNA delivery. Drug Design, Development and Terapy, 2016, 10: 1243-1255. (corresponding author)

3. Fang WJ*, Fu CY*, Chen XG, Mou XZ, Liu FL, Qian H, Zhao P, Zheng YL, Zheng Y, Deng J, Ye PJ, Wang YF, Zheng SS. Neurokinin-2 receptor polymorphism predicts lymph node metastasis in colorectal cancer patients. Oncology Letters, 2015, 9: 2003-2006. (co-first anthor)

4. Zhu XC, Zhang JL, Ge CT, Yu YY, Wang P, Yuan TF*, Fu CY*. Advances in cancer pain from bone metastasis. Drug Design, Development and Terapy, 2015, 9: 4239-4245. (corresponding author)

5. Zhu XC, Ge CT, Wang P, Zhang JL, Yu YY, Fu CY*. Analgesic effects of lappaconitine in leukemia bone pain in a mouse model. PeerJ, 2015, 3:e936. (corresponding author)

6. Fu CY*, Xia RL, Zhang TF, Lu Y, Zhang SF, Yu ZQ*, Jin T, Mou XZ*. Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice. PLoS ONE, 2014, 9(2): e90446. (corresponding author)

7. Fu CY1, Chen W1, Jin YT*. The complete mitochondrial genome of Phrynocephalus guinanensis (Reptilia, Squamata, Agamidae). Mitochondrial DNA,2014, 1-2.

8. Xia RL, Lu Y, Zhu LN, Zhang SF, Zhao FK, Fu CY*. Different regulatory pathways are involved in the proliferative inhibition of two types of leukemia cell lines induced by paclitaxel. Oncology Reports, 2013, 30: 1853-1859. (corresponding author)

9. Zhu LN, Fu CY*, Zhang SF, Chen W, Jin YT, Zhao FK. Novel cytotoxic exhibition mode of antimicrobial peptide anoplin in MEL cells, the cell line of murine Friend leukemia virus- induced leukemic cells. Journal of Peptide Science, 2013, 19: 566-574. (corresponding author)

10. Xia RL, Fu CY*, Zhang SF, Jin YT, Zhao FK. Study on the distribution sites and the molecular mechanism of analgesia after intracerebroventricular injection of rat/mouse hemokinin-1 in mice. Peptides, 2013, 43: 113-120. (corresponding author)

11. Fu CY, Zhao YL, Dong L, Chen Q, Ni JM*, Wang R*. In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in mice. Brain, Behavior, and Immunity, 2008, 22: 850-860.

12. Fu CY, Kong ZQ, Long Y, Chen Q, Wang R*. Cardiovascular responses to rat/mouse hemokinin-1, a mammalian tachykinin peptide: Systemic study in anesthetized rats. European Journal of Pharmacology, 2007, 572 175–181.

13. Fu CY, Tang XL, Yang Q, Chen Q, Wang R*. Effects of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on the antinociceptive activity of pethidine administered at the peripheral and supraspinal level. Behavioural Brain Research, 2007, 184: 39–46.

14. Fu CY, Yang Q, Wang KR, Kong ZQ, Chen Q, Wang R*. Rat/mouse hemokinin-1, a mammalian tachykinin peptide, markedly potentiates the antinociceptive effects of morphine administered at the peripheral and supraspinal level. Behavioural Brain Research, 2006, 170: 293–301.

15. Fu CY, Kong ZQ, Wang KR, Yang Q, Zhai K, Chen Q, Wang R*. Effects and mechanisms of supraspinal administration of rat/mouse hemokinin-1, a mammalian tachykinin peptide, on nociception in mice. Brain Research, 2005, 1056: 51–58.

16. Long Y1, Fu CY1, Tian XZ, Chen J, Han M, Wang R*. Mechanisms of relaxing response induced by rat/mouse hemokinin-1 in porcine coronary arteries: Roles of potassium ion and nitric oxide. European Journal of Pharmacology, 2007, 569: 119–125. (co-first anthor)

17. Kong ZQ1, Fu CY1, Chen Q, Wang R*. Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4-11) in anesthetized rats. European Journal of Pharmacology, 2008, 590: 310–316. (co-first anthor)

18. Chang HN, Liu BY, Qi YK (Qi, Yun-Kun), Zhou Y, Chen YP, Pan KM, Li WW, Zhou XM, Ma WW, Fu CY, Qi YM, Liu L, Gao YF. Blocking of the PD-1/PD-L1 Interaction by a D-Peptide Antagonist for Cancer Immunotherapy. Angewandte Chemie-International Edition, 2015, 54: 11760-11764

专利、著作版权等

1. 专利授权号:ZL 2011 1 0070470.1;申请人:浙江理工大学;发明创造名称:神经激肽受体拮抗剂在制备抗癌药物中的用途;发明人:付彩云 赵辅昆 张世馥 王宇沙 陈攀峰。(已转让)

2. 专利授权号:ZL 2011 1 0070497.0;申请人:浙江理工大学;发明创造名称:SR140333的抗血癌作用;发明人:付彩云 赵辅昆 张世馥 王宇沙 陈攀峰。

3. 专利授权号:ZL 2012 1 0323180.8;申请人:浙江理工大学;发明创造名称:神经激肽受体2的拮抗剂在白血病治疗中的用途;发明人:付彩云 夏瑞龙 赵辅昆 张世馥 陈攀峰 王宇沙。

4. 专利授权号:ZL 2013 1 0069107.7;申请人:浙江理工大学;发明创造名称:蜂毒抗菌肽Anoplin在食管癌治疗中的用途;发明人:付彩云,卢燕,朱丽娜,赵辅昆,张世馥。(已转让)

5. 专利授权号:ZL 2013 1 0068642.0;申请人:浙江理工大学;发明创造名称:蜂毒抗菌肽Anoplin在肝癌治疗中的用途;发明人:付彩云,卢燕,朱丽娜,赵辅昆,张世馥。

6. 专利授权号:ZL 2013 1 0069106.2;申请人:浙江理工大学;发明创造名称:蜂毒抗菌肽Anoplin在血癌治疗中的用途;发明人:付彩云,卢燕,朱丽娜,赵辅昆,张世馥
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