1987年毕业于徐州医学院医疗专业1990-1993年于徐州医学院攻读麻醉学硕士学位，2001-2003年于中国医科大学攻读博士学位

留校于附属医院麻醉科从事麻醉学医疗、教学和科研工作，先后担任住院医师/助教、主治医师/讲师、副主任医师/副教授2004年8月调入南京市鼓楼医院，2005年6月至今担任麻醉科行政主任/主任医师/教授。

1.江苏省医学重点学科（江苏省卫生厅课题，XK201140，150万）

2.脊髓水平GR-NPAS4信号通路对GABA能抑制性突触的调节在术前焦虑加重术后疼痛中的作用（国家自然科学基金面上项目，81471129，70万）

3.CREB-miR212/132-TORC1-CREB信号通路反馈性调控网络在骨癌痛维持中的作用（国家自然科学基金面上项目，81171048，55万）

4.脊髓水平KIF17-mLin10-NR2B转运通路在骨癌痛发生中的作用（国家自然科学基金面上项目，81070892，32万）

5.脊髓水平CaMKⅡ介导的KIF17-NR2B转运系统在小鼠骨癌痛形成中的作用（江苏省自然科学基金，BK2009054，8万）

6.大麻素受体CB2-NMDA受体NR2B磷酸化通路在癌性疼痛中的作用（江苏省六大人才高峰课题，2009044，3万）

1.Sun YE, Zhang W, Liu Y, Liu X, Ma Z*, Gu X. Intrathecal Injection of JWH015 Attenuates Remifentanil-Induced Postoperative Hyperalgesia by Inhibiting Activation of Spinal Glia in a Rat Model. Anesth Analg 2014,118:841-53.

2.Liu Y, Cui X, Sun YE, Yang X, Ni K, Zhou Y, Ma Z*, Gu X. Intrathecal Injection of the Peptide Myr-NR2B9c Attenuates Bone Cancer Pain Via Perturbing N-Methyl-d-Aspartate Receptor-PSD-95 Protein Interactions in Mice. Anesth Analg 2014,118:1345-54.

3.Zhang W, Liu Ym Zhao X, Gu X, Ma Z*. The Effect of Intrathecal Administration TRPA1 Antagonists in a Rat Model of Neuropathic Pain. Anesth Analg 2014,119:179-85.

4.Xia T, Cui Y, Shi H, Ma Z*, Gu X. The Effect of NR2B Subunit Palmitoylation at the Spinal Level After Chronic Dorsal Root Ganglia Compression in Rats. Anesth Analg 2014 [Epub ahead of print]

5.Liu X, Liu Y, Zhang J, Zhang W, Sun YE, Gu X, Ma Z*. Intrathecal administration of roscovitine prevents remifentanil-induced postoperative hyperalgesia and decreases the phosphorylation of N-methyl-d-aspartate receptor and metabotropic glutamate receptor 5 in spinal cord. Brain Res Bull. 2014,106:9-16.

6.Ni K, Zhou Y, Sun Y, Liu Y, Gu X, Ma Z*. Intrathecal injection of selected peptide Myr-RC-13 attenuates bone cancer pain by inhibiting KIF17 and NR2B expression. Pharmacology, Biochemistry and Behavior 2014,122:228-233.

7.Liu Y, Liang Y, Hou B, Liu M, Yang X, Liu C, Zhang J, Zhang W, Ma Z*, Gu X. The inhibitor of calcium/calmodulin-dependent protein kinase II KN93 attenuates bone cancer pain via inhibition of KIF17/NR2B trafficking in mice. Pharmacol Biochem Behav 2014,124:19-26.

8.Yang L, Gu X, Zhang W, Zhang J, Ma Z*. Cdk5 inhibitor roscovitine alleviates neuropathic pain in the dorsal root ganglia by downregulating N-methyl-D-aspartate receptor subunit 2A. Neurol Sci 2014 [Epub ahead of print].

9.Zhang J, Zhang W, Sun YE, Liu Y, Song L, Ma Z*, Gu X. Activation of GRs-Akt-nNOS-NR2B signaling pathway by second dose GR agonist contributes to exacerbated hyperalgesia in a rat model of radicular pain. Mol Biol Rep 2014,41:4053-61.

10.Li B, Yan J, Shen Y, Liu Y, Ma Z*. Dichloroacetate prevents but not reverses the formation of neointimal lesions in a rat model of severe pulmonary arterial hypertension. Mol Med Rep 2014,10(4):2144-52.

11.Zhang W, Sun X, Bo J, Zhang J, Liu X, Wu L, Ma Z*, Gu X. Activation of mTOR in the spinal cord is required for pain hypersensitivity induced by chronic constriction injury in mice. Pharmacol Biochem Behav 2013,111:64-70.

12.Jiang M, Zhang W, Ma Z*, Gu X. Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-d-aspartate receptor. Pharmacol Biochem Behav 2013,112(1):56-63.

13.Gu X, Bo J, Zhang W, Sun X, Zhang J, Yang Y, Ma Z*. Intrathecal administration of cyclic AMP response element-binding protein-antisense oligonucleotide attenuates neuropathic pain after peripheral nerve injury and decreases the expression of N-methyl-D-aspartic receptors in mice. Oncol Rep 2013,30(1):391-8.

14.Zhu W, Shi X, Xiao J, Gu G, Ding Y, Ma Z*. Effects of xenogeneic adipose-derived stem cell transplantation on acute-on-chronic liver failure. Hepatobiliary Pancreat Dis Int 2013, 12:60-67.

15.Jiang Z, Liu Y, Zhang W, Ma Z*. Pseudo-hypotension in patients with ankylosing spondylitis during posterior osteotomy for correction of kyphosis. J Clin Anesth 2013,25:9-11.

16.Ren B, Gu X, Zheng Y, Liu C, Wang D, Sun Y, Ma Z*. Intrathecal Injection of Metabotropic Glutamate Receptor Subtype3 and 5 Agonist/Antagonist Attenuates Bone Cancer Pain by Inhibition of Spinal Astrocyte Activation in a Mouse Model. Anesthesiology 2012,116(1):122-32.

17.Li B, Yan J, Shen Y, Li B, Hu Z, Ma Z*. Association of sustained cardiovascular recovery with epinephrine in the delayed lipid-based resuscitation from cardiac arrest induced by bupivacaine overdose in rats. British Journal of Anaesthesia 2012,108(5):857-63.

18.Zheng Y, Cui S, Liu Y, Zhang J, Zhang W, Zhang J, Gu X, Ma Z*. Dexmedetomidine prevents remifentanil-induced postoperative hyperalgesia and decreases spinal tyrosine phosphorylation of N-methyl-d-aspartate receptor 2B subunit. Brain Research Bulletin 2012,87:427-431.

19.Sun Y, Peng L, Sun X, Bo J, Yang D, Zheng Y, Liu C, Zhu B, Ma Z*, Gu X. Intrathecal Injection of Spironolactone Attenuates Radicular Pain by Inhibition of Spinal Microglia Activation in a Rat Model. PloS One 2012,7(6):e39897.

20.Xie W, Yang Y, Gu X, Zheng Y, Sun Y, Liang Y, Bo J, Ma Z*. Senegenin Attenuates Hepatic Ischemia-Reperfusion Induced Cognitive Dysfunction by Increasing Hippocampal NR2B Expression in Rats. PloS One 2012,7(9):e45575.

21.Liu Y, Zheng Y, Gu X, Ma Z*. The Efficacy of NMDA receptor antagonists for preventing remifentanil-induced increase in postoperative pain and analgesic requirement: A Meta-Analysis. Minerva Anestesiol 2012,78:653-67.

22.Zhang R, Liu Y, Gu X, Zhang J, Zheng Y, Ma Z*. Intrathecal administration of Roscovitine attenuates cancer pain and inhibits the expression of NMDA receptor 2B subunit mRNA. Pharmacol Biochem Behav 2012,102:139-45.

23.Jiang Z, Liu Y, Ma Z*. A venipuncture needle exchange device designed for central venous catheterization. J Clin Anesth 2012,24(7):605-6.

24.Jiang Z, Wu X, Liu Y, Ma Z*. Reflux-preventing face mask designed for painless gastroscopy. J Clin Anesth. 2012,24(5):432.

25.Gu X, Mei F, Liu Y, Zhang Rui, Zhang J, Ma Z*. Intrathecal administration of cannabinoid 2 receptor agonist JWH015 can attenuate cancer pain and decrease mRNA expression of 2B subunit of NMDA. Anesthesia and Analgesia 2011,113(2):405-11.

26.Gu X, Peng L, Yang D, Ma Q, Zheng Y, Liu C, Zhu B, Song L, Sun X, Ma Z*. The respective and interaction effects of spinal GRs and MRs on radicular pain induced by chronic compression of the dorsal root ganglion in the rat. Brain research 2011,1396:88-95.

27.Gu X, Zheng Y, Ren B, Zhang R, Mei F, Zhang J, Ma Z*. Intraperitoneal injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model. Molecular pain 2010, 31(6):64-73.

28.Gu X, Zhou X, Zheng Y, Zhang J, Wang J, Ma Z*. Involvement of the spinal NMDA receptor/PKCgamma signaling pathway in the development of bone cancer pain. Brain research 2010, 1335(4):83-90.

29.Gu X, Zhang J, Ma Z*, Wang J, Zhou X, Jin Y, Xia X, Gao Q, Mei F. The role of N-methyl-d-aspartate receptor subunit NR2B in spinal cord in cancer pain. Eur J Pain 2010,14(5):496-502.

30.Gu X, Wu X, Liu Y, Cui S, Ma Z*. Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine. Molecular Pain 2009,30 (5):76.

31.Zhang W, Shi C, Gu X, Ma Z*, Zhu W. Ifenprodil Induced Antinociception and Decreased the Expression of NR2B Subunits in the Dorsal Horn After Chronic Dorsal Root Ganglia Compression in Rats. Anesthesia and Analgesia 2009, 108(3):1015–1020.

32.Ma Z*, Zhu W, Zhang W, Gu X. Effect of the synaptic scaffolding protein Homer1a on chronic compression of dorsal root ganglion. Ann Clin Lab Sci 2009, 39(1):71-75.

33.刘玥, 侯百灵, 刘明, 夏天娇, 孙蓓, 张羽, 冷鑫, 石林玉, 顾小萍, 马正良*. 脊髓神经元微小RNA-132在小鼠骨癌痛中的作用. 中华麻醉学杂志 2014,34(6):691-695.

34.张伟，赵鑫，程崇学，顾小萍，马正良*. 脊髓背角神经元瞬时受体电位离子通道1在大鼠神经病理性痛维持中的作用. 中华麻醉学杂志. 2014,34(1):37-39.

35.石林玉，张娟，孔明健，徐黎，刘明，沈羽，刘玥，顾小萍，马正良*. 脊髓神经元限制性沉默因子在瑞芬太尼诱发切口痛小鼠痛觉过敏中的作用. 中华麻醉学杂志. 2014,34(3):279-282.

36.张羽，孙蓓，刘玥，侯百灵，冷鑫，马正良*. 骨癌痛小鼠痛行为及脊髓背角磷酸化环磷酸腺苷反应元件结合蛋白和脑源性神经营养因子表达的改变. 国际麻醉学与复苏杂志. 2014,35(7):617-621.

37.冯丹丹，马正良*，顾小萍. 每搏量变异度和中心静脉压指导老年胃肠手术术中液体管理的比较. 国际麻醉学与复苏杂志. 2014,35(4):300-304.

38.侯百灵，刘玥，夏天娇，张羽，孙蓓，冷鑫，周瑜，倪坤，顾小萍，马正良*. miR-212 在小鼠骨癌痛发展中的作用. 中华行为医学与脑科学杂志. 2013,22(10): 869-872.

39.张伟，赵鑫，顾小萍，马正良*. 瞬时受体电位离子通道1 拮抗剂对大鼠切口痛模型术后疼痛的影响. 中华实验外科学杂志. 2013,30(10):2191-2193.

40.胡丽君，李勇，顾小萍，马正良*. 右旋美托咪定对脊柱侧弯矫形术患者术中唤醒的影响. 国际麻醉学与复苏杂志. 2013,34(4):304-307.

41.周瑜，倪坤，崔昕龙，侯百灵，顾小萍，马正良*. 单次鞘内注射mLin10-PDZ1结构域小肽抑制剂对骨癌痛小鼠痛行为学的影响. 国际麻醉学与复苏杂志. 2013,34(6):484-487.

42.张杰杰，马正良*，宋杰. 芬太尼抑制瑞芬太尼静脉复合麻醉苏醒期疼痛的ED50. 临床麻醉学杂志. 2013,29(6):532-534.

43.王丹，任炳旭，刘成龙，朱洁，张娟，张威，梅凤美，顾小萍，马正良*. 大麻素CB2受体在小鼠骨癌痛形成中的作用. 中华医学杂志. 2012,92(7):440-443.

44.梁樱，刘成龙，张娟，杨许丽，朱洁，申艳，顾小萍，马正良*. 脊髓钙/钙调蛋白依赖性蛋白激酶II-NR2B信号通路参与小鼠骨癌痛的形成. 中华行为医学与脑科学杂志. 2012,21(4):315-317.

45.倪坤，周瑜，崔昕龙，吴刘萍，杨许丽，朱洁，顾小萍，马正良*. 鞘内注射驱动蛋白17竞争性小肽抑制剂对骨癌痛小鼠的镇痛效果. 中华麻醉学杂志. 2012,32(9):1096-1099.

46.孙玉娥，马正良*，郑亚国，张娟，顾小萍. 鞘内注射不同剂量硫酸镁对小鼠骨癌痛的影响. 中华麻醉学杂志. 2012,32(3):334-337.

47.孙玉娥，马正良*，郑亚国，张娟，杨许丽，朱洁，顾小萍. 鞘内注射硫酸镁对骨癌痛小鼠痛行为的影响. 中华行为医学与脑科学杂志. 2012,21(4):306-310.

48.杨许丽，马正良*，朱洁，崔昕龙，梁樱，申艳，刘玥，顾小萍. 艾芬地尔重复鞘内注射对骨癌痛模型小鼠痛行为的影响.中华行为医学与脑科学杂志. 2012,21(3):228-231.

49.刘玥，郑亚国，顾小萍，马正良*. NMDA受体拮抗剂预防瑞芬太尼诱发术后痛觉过敏的效果：meta分析. 中华麻醉学杂志. 2011,31(10):1170-1174.

50.朱洁，刘成龙，马正良*. KIF17：一个N-甲基-D-天冬氨酸受体的转运蛋白. 国际麻醉学与复苏杂志. 2012, 33(6):392-395.

51.张睿，顾小萍，张娟，马正良*. 椎管内麻醉后寒战发生的危险因素及预防的回顾性研究. 2012,35(27):20-22.

52.申艳，李冰冰，杨许丽，朱杰，梁樱，马正良*. 生存素在二氯乙酸盐治疗大鼠肺动脉高压中的表达变化. 2012,33(9):597-599.

53.孙文晋，马正良*，杭黎华，陈正，吴进. 硫酸镁抑制瑞芬太尼术后痛觉过敏的半数有效量测定. 江苏大学学报（医学版）. 2012,22(6):551-552.

54.任炳旭，顾小萍，朱炜，郑亚国，刘成龙，王丹，马正良*. 鞘内注射代谢性谷氨酸受体亚型5拮抗剂对骨癌痛小鼠痛行为及脊髓水平星形胶质细胞活化的影响. 中华行为医学与脑科学杂志. 2011,20(4):295-297.

55.任炳旭，马正良*，靳艳卿，朱炜，谢伟斌. 身痛逐瘀汤对骨癌痛小鼠痛行为及脊髓星形胶质细胞活化的影响. 中国中西医结合杂志. 2011,31(3):381-385.

56.任斌旭，顾小萍，刘成龙，王丹，马正良*. 骨癌痛形成过程中小鼠脊髓水平代谢性谷氨酸受体亚型3和5的表达变化. 中国疼痛医学杂志. 2011,17(6):361-365.

57.郝静，吴浩，马正良*，金陵，顾小萍. 右美托咪定对后腹腔镜手术患者术中血流动力学的影响. 中国微创外科杂志. 2011,11(3):215-219.

58.殷霞丽，马正良*. 曲马多用于术后镇痛的效果及安全性的Meta分析. 临床麻醉学杂志. 2011,27(10):965-967.

59.周路阳，马正良*，何亮亮. 不同剂量氯胺酮复合丙泊酚诱导在全麻剖宫产中的应用. 临床麻醉学杂志. 2011,27(12):1200-1201.

60.王强，马正良*，刘礼军，杜勤芳，鲍方，何凤勇，杨初华. 依托咪酯keo用于靶控输注系统的性能. 临床麻醉学杂志. 2011,27(5):424-425.

61.郑亚国，马正良*. 肿瘤坏死因子-α和神经病理性疼痛. 国际麻醉学与复苏杂志. 2011,32(1):101-103.

62.王尔华，陶佳，顾小萍，马正良*. 超声引导神经阻滞辅以瑞芬太尼用于膝部以下手术麻醉的观察. 临床麻醉学杂志. 2011,27(11):1053-1055.

63.刘伟，饶丽华，郭淑静，陈斌，马正良*. 七氟醚复合丙泊酚静吸复合麻醉对老年食管癌患者术后早期认知功能的影响. 临床麻醉学杂志. 2011,27(4):373-375.

64.李勇，胡丽君，马正良*. 右美托咪定对脊柱侧弯矫形术患者全麻诱导和术中唤醒时血流动力学的影响. 临床麻醉学杂志. 2011,27(12):1185-1187.

65.刘成龙，马正良*，梁樱，彭良玉，任炳旭，刘晓杰，顾小萍. 鞘内注射钙/钙调蛋白依赖性蛋白激酶Ⅱ抑制剂KN93对骨癌痛小鼠痛行为的影响. 中华行为医学与脑科学杂志2010,19(10):867-869.

66.郑亚国，马正良*，梅凤美，张睿，任炳旭，张娟，顾小萍. 腹腔注射沙利度胺对骨癌痛小鼠痛行为的影响.中华行为医学与脑科学杂志2010,19(11):1005-1007.

67.张娟，马正良*，顾小萍，周晓芳，高勤，王俊华，夏小萍. 骨癌痛发生过程中脊髓水平诱导型一氧化氮合酶的表达变化.中华行为医学与脑科学杂志2010,19(9):830-831.

68.高勤，顾小萍，张娟，周晓芳，王俊华，马正良*. 脊髓TNF-α在小鼠骨癌痛发生中的作用. 中华麻醉学杂志2010,30(3):331-333.

69.于淑侠，马正良*，顾小萍，王尔华. 利多卡因持续静脉泵注对鼻内窥镜术中异氟醚用量及术后疼痛的影响. 临床麻醉学杂志. 2010,26(6);494-496.

70.姜敏，马正良*，顾小萍，张娟，刘成龙. 缺血再灌注损伤后大鼠神经功能改变及大脑Homer1蛋白的表达. 东南大学学报（医学版）. 2010,29(5);546-549.

71.张睿，马正良*，梅凤美，张娟，顾小萍. 鞘内注射Roscovitine对小鼠骨癌痛行为学的影响. 国际麻醉学与复苏杂志. 2010,31(2);111-114.

72.吴晓丽，马正良*，顾小萍，崔松勤. 氯胺酮预防瑞芬太尼痛觉过敏的实验研究. 国际麻醉学与复苏杂志. 2010,31(2);115-122.

73.冯丹丹，马正良*. 围术期体温保护研究进展. 国际麻醉学与复苏杂志. 2010,31(3):274-277.

74.王喆妍，骆璇，王东进，马正良*. 门冬氨酸钾镁在心脏瓣膜体外循环术中对CK-MB和cTnT的影响. 江苏医药. 2010,36(11):1259-1260.

75.胡永明，马正良*. 预先静脉注射帕瑞昔布钠对术后芬太尼患者自控镇痛的影响. 江苏医药. 2010,36(6):659-661.

76.王强，马正良*，刘礼军，鲍方，桂勤芳. 依托咪酯诱导全麻经口插管的临床观察. 徐州医学院学报. 2010,30(10):638-640.

77.宋芬，顾小萍，马正良*. 腰-硬联合麻醉在老年患者腔内泌尿外科微创手术中的应用. 临床麻醉学杂志. 2010,26(3):227-229.

78.梅凤美，马正良*，张睿，顾小萍，张娟，周晓芳，史长喜. 鞘内注射大麻素受体2激动剂JWH015对骨癌痛小鼠痛行为的影响. 中华行为医学与脑科学杂志2009,18(11):976-978.

79.周晓芳，马正良*，王俊华，张娟，高勤，夏小萍，梅凤美. 鞘内注射艾芬地尔对骨癌痛小鼠脊髓NR2B mRNA表达的影响. 中华麻醉学杂志. 2009,29(1):14-17.

80.王俊华，张娟，周晓芳，马正良*，夏小萍，高勤，梅凤美，张睿. 艾芬地尔鞘内注射对骨癌痛模型小鼠痛行为的改善作用. 中华行为医学与脑科学杂志. 2009,18(2):136-139.

81.杨磊，马正良*，史长喜，钟妤，顾小萍. 鞘内注射Roscovitine缓解大鼠慢性神经病理性疼痛. 临床麻醉学杂志. 2009,25(4);335-337.

82.高勤，马正良*，张娟，周晓芳，王俊华，顾小萍，夏小萍. 脊髓水平肿瘤坏死因子-α在小鼠骨癌痛发生中的作用. 国际麻醉学与复苏杂志. 2009,30(2);130-133.

83.史长喜，马正良*，钟妤，张伟，杨磊，顾小萍. CB2受体激动剂JWH015对大鼠神经病理性疼痛的治疗作用. 国际麻醉学与复苏杂志. 2009,30(3);231-235.

84.钟妤，马正良*. 鞘内注射细胞周期素依赖性激酶-5抑制剂Roscovitine对慢性背根节压迫大鼠痛行为学的影响. 国际麻醉学与复苏杂志. 2010,30(5):418-421.

85.方吉，周路阳，李榕，马正良*. 丙泊酚靶控输注对鼻内镜手术病人应激反应的影响. 中国微创外科杂志. 2009,9(12):1116-1118.

86.金陵，马正良*，陶佳，郝静. 不同麻醉方法对老年高血压下肢手术患者血流动力学的影响. 江苏医药. 2009,35(9):1011-1013.

87.蒋忠，马正良*，董媛媛. 妇科腹腔镜手术对患者眼内压的影响. 临床麻醉学杂志. 2009,25(11):948-949.

88.董媛媛，蒋忠，马正良*. 雷米芬太尼对妇科腹腔镜术中眼内压的影响. 国际麻醉学与复苏杂志. 2009,30(1):27-29.

89.王强，马正良*，刘礼军，张马忠，桂勤芳，鲍方，何凤勇，杨初华. 频谱熵和双频指数用于测定依托咪酯血浆效应室平衡速率常数的比较. 临床麻醉学杂志. 2009,25(3):208-211.

获得实用新型专利4项