教育背景
工作经历
项目课题经历
30872979
hTERT T细胞表位特异性细胞毒性T细胞克隆及其受体的研究
面上项目
2008
81172106
SFRPs家族基因甲基化在人肺腺癌多药耐药表型形成中的作用及其机制研究
面上项目
2011
81071806
miR-200b/Bcl-2通路参与调控人肺腺癌多药耐药表型形成的分子机制研究
面上项目
2010
81272474
HDAC/Sp1复合物负向调控microRNA-200b表达参与人肺腺癌化疗耐药表型形成的分子机制研究
面上项目
2012
论文、成果、著作等
发表SCI论文40多篇1. HMGB1-mediated autopgagy promotes docetaxel resistance in human lung adenocarcinoma. Mol Cancer,2014;5(13)165
2. HDAC1/4-mediated silencing of microRNA-200b promotes chemoresistance in human lung adenocarcinoma cells. Oncotarget. 2014 ;5(10):3333-49.
3. secreted frizzled related protein1. Mol Med,2014;8(20):164-78.
4. MicroRNA145: a potent tumor suppressor. J Cell Mol Med,2014[Epub ahead of print].
5. acquisition of radioresistance in docetaxel resistance human lung adenocarcinoma. Oncotarget 2014;5(15):6113-29.
6. The role of Aurora A in hypoxia-inducible factor 1α-promoting malignant phenotypes of hepatocelluar carcinoma. Cell Cycle. 2013;12(17):2849-66.
7. Let-7c governs the acquisition of chemo- or radioresistance and epithelial-to-mesenchymal transition phenotypes in docetaxel-resistant lung adenocarcinoma. Mol Cancer Res. 2013 11(7):699-713.
8. Inhibition of ZEB1 reverses EMT and chemoresistance in docetaxel-resistant human lung adenocarcinoma cell line. J Cell Biochem. 2013;114(6):1395-403.
9. Identification of ING4 (inhibitor of growth 4) as a modulator of docetaxel sensitivity in human lung adenocarcinoma. Mol Med. 2012;18:874-86.
10. MicroRNA-200b reverses chemoresistance of docetaxel-resistant human lung adenocarcinoma cells by targeting E2F3. Cancer. 2012 ;118(13):3365-76.
11.MiR-100 resensitizes docetaxel-resistant human lung adenocarcinoma cells (SPC-A1) to docetaxel by targeting Plk1. Cancer Lett. 2012;317(2):184-91.
12. MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14). Oncogene. 2011;30(23):2644-58.
13. Methylation of multiple genes as a candidate biomarker in non-small cell lung cancer. Cancer Lett. 2011;303(1):21-8. .
14. Preconditioning chemotherapy with paclitaxel and cisplatin enhances the antitumor activity of cytokine induced-killer cells in a murine lung carcinoma model. Int J Cancer. 2011;129(3):648-58.
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